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Lung thrombopoiesis in pregnant rabbits during septic shock - an ultrastructural study

100%
Sulkowska M., Terlikowski S., Famulski W., Sulkowski S.
Bulletin of the Veterinary Institute in Puławy
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2001
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tom 45
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nr 1
The aim of the present study was the comparative analysis of morphological changes found in the pulmonary microcirculation of pregnant rabbits in the course of experimental septic shock induced by endotoxin administration. Sixteen female rabbits, white Dutch, c.3 kg of mean body weight were used in the experiments. The endotoxin of Escherichia coli, serotype S.0127:138 (Sigma) was applied intraperitoneally in a single dose of 100 μg/kg b.w. Morphological examinations were based on the ultrastructural analysis with the transmission electron microscope. Severe damage of endothelial cells (necrosis inclusive) was observed in endotoxin-treated rabbits. The vascular lumen in these animals showed cellular aggregation of neutrophils and platelets in particular, as well as microthrombi. Some of the blood vessels showed fragments of megakaryocytes. An increased tendency towards the development of these changes was noted in pregnant rabbits. The study confirmed that the lungs may be an important site of extramedullary thrombopoiesis in the course of septic shock especially during pregnancy.
2

Relationship between anemia, iron deficiency, and platelet production in dogs

84%
Matur E., Ergul Ekiz E., Erek M., Ergen E., Kucuk S. H., Erhan S., Ozcan M.
Medycyna Weterynaryjna
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2019
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tom 75
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nr 06
Platelet production increases in anemic people. In particular, iron deficiency causes reactive thrombocytosis in such patients. Although anemia and iron deficiency are frequently seen in dogs, there are no published studies on this subject. The aim of the present study was to investigate the relationship between anemia, iron deficiency, and platelet production in dogs. A total of 81 dogs brought to the university animal hospital with signs of anemia were used. Haemogram parameters, serum iron (Fe), erythropoietin (EPO), and thrombopoietin (TPO) levels, as well as total iron binding capacity (TIBC), were measured. Transferrin saturation (TSAT) ratios were calculated. The animals were categorized as anemic or non-anemic, mildly anemic or moderately/ severely anemic, and having iron deficiency or no iron deficiency according to haemogram parameters and the serum Fe level. A high platelet number was observed in dogs with mild anemia. Dogs with mild anemia also had higher serum EPO levels than dogs with moderate/severe anemia (P = 0.047). Iron deficiency was detected in 31 dogs. The platelet number was higher in dogs with iron deficiency (P = 0.004). It was also observed that dogs with iron deficiency had higher serum EPO levels (P = 0.027) and lower TPO levels (P = 0.025) than dogs without iron deficiency. In conclusion, it can be said that mild anemia and iron deficiency cause thrombocytosis in dogs. The increased serum EPO levels, both in dogs with mild anemia and those with iron deficiency, suggest that the increase in platelet production is due to EPO. Nevertheless, there is a need for further research to fully understand the underlying mechanism.
3

Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase

84%
Kaminska J., Klimczak-Jajor E., Skierski J., Bany-Laszewicz U.
Acta Biochimica Polonica
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2008
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tom 55
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nr 3
499-506
α1,6-fucosyltransferase (FUT8) attaches fucose residues viaan α1,6 linkage to the innermost N-acetylglucosamine residue of N-linked glycans. Glycans with this type of structure are present in GpIIb/GpIIIa complex (CD41a) which is present on megakaryocytes (Mks) and platelets. CD41a is the earliest marker of megakaryocytopoiesis. The aim of this study was to analyse the morphology, phenotype, ploidy level and activity of FUT8 during induced differentiation/maturation of Mk progenitor cells in ex vivoculture. We used SU6656, a selective inhibitor of Src tyrosine kinases, as differentiation-inducing agent for Mks. The addition of SU6656 to the culture system of megakaryocytic progenitors from cord blood CD34+cells and Meg-01 cell line induced their maturation towards later stages of Mk differentiation with increased activity of FUT8. We suggest FUT8 as a candidate for an early marker of differentiation and possibly of the ploidy level of Mks. We confirm a special status of FUT8 in megakaryocytopoiesis.
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