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1

Thrombocytopenia as a characteristic trait in the Polish ogar dog

100%
Micun J., Sobczak-Filipiak M., Winnicka A., Mieczkowska J., Zmudzka M., Garncarz M., Sokolowska J., Lechowski R.
Polish Journal of Veterinary Sciences
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2009
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tom 12
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nr 4
The study was undertaken to ascertain if the normal thrombocyte count in Polish ogar dog differs from normal values in other dog breeds. The reason for this study was constatation that during routine blood analysis in healthy Polish ogar dogs, thrombocytopenia, not related to the clinical state of the animals, was frequently encountered. The study was carried out on 38 Polish ogar dogs. The control group consisted of 80 dogs of various breeds. All the animals were clinically healthy. A full hematological analysis was performed. The mean platelet value in all dog breeds without the Polish ogar dogs was 344.4 ± 6.85, while the mean number of platelets in the Polish ogar dogs amounted to 167 ± 11.6 G/l. The limited genetic material used to rebuild the Polish ogar breed after its drastic decline during the Second World War could be the reason for various, including hematological, abnormalities that with time became a normal characteristic traits for this breed.
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Evaluation of antidote potential of methanol leaf extract of Bauhinia monandra on heparin-induced thrombocytopenia in mice

84%
Nworie K. M., Okorie A. N., Ebere D. N., Obike O. C.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2019
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tom 100
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nr 1
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Bovine neonatal pancytopenia in calves in Poland

84%
Jaskowski J. M., Polak M. P., Marszalek A., Nowak K., Frackowiak H., Olechnowicz J.
Polish Journal of Veterinary Sciences
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2012
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tom 15
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nr 3
Bovine neonatal pancytopenia (BNP), a newly emerged syndrome of discussed etiology in calves, has been diagnosed since 2006. Here we describe first cases of BNP in Poland. Between September 2008 and April 2011, 62 cases of BNP were diagnosed in dairy calves. Bleeding skin lesions were mostly pronounced in summer and early autumn. Severe thrombocytopenia was observed in all sick animals. All calves came from herds vaccinated against BVDV infection with PregSure BVD vaccine (Pfizer). Substitution of colostrum from dams of BNP positive calves with colostrum from dams from herds free of BNP was the only effective measure to avoid new cases in affected herds.
4

The clinical course of babesiosis in 76 dogs infected with protozoan parasites Babesia canis canis

84%
Adaszek L., Winiarczyk S., Skrzypczak M.
Polish Journal of Veterinary Sciences
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2009
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tom 12
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nr 1
The aim of the study was to trace the clinical course of babesiosis in 76 dogs infected with Babesia canis protozoa and to assess the usefulness of PCR method in the routine diagnosis of the disease. The investigations were conducted in three successive seasons of the biological activity of ticks on dogs displaying possible clinical signs of babesiosis, the latter assigned individual numbers from 001 to 076. All the animals underwent routine clinical examinations and blood was collected for haematological, biochemical, parasitological and molecular tests for babesiosis. The most frequent clinical signs observed in the course of the disease were changes in urine colour and xanthosis or paleness of mucous membranes, whereas in the haematological and biochemical examinations, the most frequent laboratory findings were thrombocytopenia, leucopoenia, anaemia and an increase in levels of urea and bilirubin. In all blood smears stained with the May-Grunwald and Giemsa methods, from the 76 dogs, the presence of Babesia canis protozoa was observed in erythrocytes, and their DNA was detected in 69 blood samples by means of PCR technique. The course of the disease and the results of molecular examinations suggested the haemolytic form of babesiosis. The previous genetic analysis of isolates of Babesia canis canis from the eastern areas of Poland helped to distinguish two specific groups, A and B, within the species (Adaszek and Winiarczyk 2008a). The present study revealed a certain interrelation between the intensification of thrombocytopenia and the fact that protozoa belong to either group A or B. The mean number of thrombocytes in dogs infected with protozoa from group A was 61.11 thousand/mm3, whereas the mean number of thrombocytes in the blood of dogs infected with protozoa from group B was 27.47 thousand/mm3. A strong correlation was also observed between the low level of thrombocytes and the increase in the internal body temperature (p=0.02), accelerated pulse rate (p=0.01) and discoloration of urine (p=0.04). As a result of the treatment of dogs with imidocarb, recovery was observed in 73 out of the 76 dogs brought to the clinic.
5

The activity of alpha 1,6-fucosyltransferase during human megakaryocytic differentiation

84%
Bany-Laszewicz U., Kaminska J., Klimczak-Jajor E., Koscielak J.
Cellular and Molecular Biology Letters
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2004
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tom 09
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nr 1
α1,6-Fucosyltransferase (6FucT, E.C. 2.4.1.68) is one of the enzymes involved in the synthesis of N-linked glycans of the GpIIb/IIIa complex (CD41a) which is present on megakaryocytes (MKs) and platelets. In this study, we examined 6FucT activity in ex vivo cultures of immunoselected cord blood CD34+ cells grown in a medium promoting megakaryocytopoiesis. Our results show that the activity of 6FucT increased ahead of, and thereafter concomitantly with, cells expressing the CD41a antigen. When the CD41a+ subpopulation of cells was immunoselected (using anti-CD61 i.e. anti-GpIIIa antibodies), its 6FucT activity increased proportionally to the yield of CD61+ cells. Taking into account the heavy load of 6FucT in platelets and megakaryocytes, we regard this enzyme as a candidate for the earliest marker of MK-commitment in cultured hematopoietic stem cells. Such a marker should allow an earlier detection and earlier transplantation of patients’ own, ex vivo expanded, Mk progenitors.
6

Influence of different temperature of cryopreservation on the proliferative potential of human bone marrow progenitor cells. Transplantological implications

84%
Ratajczak M. Z., Kuczynski W. I., Ratajczak J.
Archivum Immunologiae et Therapiae Experimentalis
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1994
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tom 42
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nr 3
7

Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax – malaria in India and Saudi Arabia

67%
Khan W., Zakai H. A., Asma U.
Acta Parasitologica
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2014
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tom 59
|
nr 2
Malaria is one of the most devastating diseases of tropical countries with clinical manifestations such as anaemia, splenomegaly, thrombocytopenia, hepatomegaly and acute renal failures. In this study, cases of thrombocytopenia and haemoglobinemia were more prominent in subjects infected with Plasmodium falciparum (Welch, 1897) than those with Plasmodium vivax (Grassi et Feletti, 1890). However, anaemia, jaundice, convulsions and acute renal failure were significantly high (3–4 times) in subjects infected with P. falciparum than those infected with P. vivax. The incidence of splenomegaly and neurological sequelae were 2 and 6 times higher in P. falciparum infections compared to the infections of P. vivax. Both in P. vivax and P. falciparum malaria, the cases of splenomegaly, jaundice and neurological sequelae were almost double in children (<10 years) compared to older patients. The liver enzymes were generally in normal range in cases of low and mild infections. However, the AST, ALT, ALP activities and serum bilirubin, creatinine, and the urea content were increased in P. falciparum and P. vivax malaria patients having high parasitaemia, confirming liver dysfunction and renal failures in few cases of severe malaria both in India and Saudi Arabia.
8

Gaucher disease diagnosed after bone marrow trephine biopsy — a report of two cases

67%
Sokolowska B., Skomra D., Czartoryska B., Tomczak W., Tylki-Szymanska A., Gromek T., Dmoszynska A.
Folia Histochemica et Cytobiologica
|
2011
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tom 49
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nr 2
9
Content available remote

Heparin-induced thrombocytopenia in a patient with massive lung embolism and left-sided pneumonia: a case report

67%
Doboszynska A., Rozek M., Swietlik E., Tomaszewska I.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
10

The levels of glycosphingolipids, ceramides, sialic acid and glycogen are changed in plasma membranes of rat platelets harvested during recovery from immune-mediated thrombocytopenia

67%
Zdebska E., Soszynska B., Dobrowolski Z., Koscielak J.
Acta Biochimica Polonica
|
1996
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tom 43
|
nr 3
Plasma membranes of rat platelets produced at normal platelet counts and during early recovery from immune-mediated thrombocytopenia were examined for the contents of carbohydrates, lipids and glycosphingolipids. Glucosylceramide, two monosialo-gangliosides and one disialo-ganglioside were found to be the major glycosphingolipids of platelets. During thrombocytopenia the contents of these glycosphingolipids as well as of ceramides were several fold elevated. Among carbohydrate constituents of platelets and platelet plasma membranes, glycogen content was increased and that of sialic acid decreased. These results are discussed in the light of literature data on relevant biochemical characteristics of megakaryocytes at different stages of maturation and on thrombopoiesis during acute experimental thrombocytopenia.
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