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1
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Saline containing phosphatidylcholine liposomes possess the ability to restore endothelial function damaged resulting from gamma-irradiation

100%
Soloviev A. I., Stefanov A. V., Tishkin S. M., Khromov A. S., Parshikov A. V., Ivanova I. V., Gurney A. M.
Journal of Physiology and Pharmacology
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2002
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tom 53
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nr 4,1
The protective action of passive saline filled ("empty") phosphatidylcholine liposomes (PCL) on endothelial function was examined in thoracic aortas obtained from gamma irradiated (6 Gy) Chinchilla rabbits, and then verified in experiments on non-anesthetized and anesthetized rats. Acetylcholine (ACh)-induced vascular relaxant responses in isolated vascular tissues rats were used as the test of endothelial integrity and its functional ability. It was shown that when added to the bath solution (100 µg/ml), PCL effectively restored endothelium-dependent ACh relaxations of isolated vascular rings damaged resulting from -irradiation but had no effect on endothelium-independent vascular responses to therapeutic nitric oxide (NO) donors. The liposomes were also without protective effect when injected to the rabbits intraperitoneally (30 mg/kg) 1 hour before irradiation. In contrast, PCL, being injected at the same dose 1 hour after radiation impact, promote normalization of both endothelium-dependent vascular responses to ACh and nitric oxide (NO) donors. PCL restored also the sensitivity of vascular tissues to authentic NO (aqueous NO solution) that was surprisingly increased after irradiation, and normalized relationship between ACh-stimulated NO release and relaxant response amplitudes in irradiated aortas. Experiments on non-anesthetized and anesthetized rats demonstrated that irradiation led to significant elevation in the level of arterial blood pressure without any changes in cardiac contractility. PCL administration (25 mg/kg, i.v.) effectively normalized an increased arterial blood pressure in irradiated animals. In conclusion, it appears that PCL due to its ability to normalize NO- dependent vascular tone control mechanisms might be worthwhile therapeutic approach in case of ionizing irradiation accident. These result support the concept that the depression of endothelium-dependent vascular responses after irradiation may be result of decreased NO bioavailability due to its conversion to less potent vasodilators during irradiation-induced oxidative attack.
2
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Farnesoid X receptor regulates vascular reactivity through nitric oxide mechanism

84%
Zhang R., Ran H.-H., Zhang Y.-X., Liu P., Lu C.-Y., Xu Q., Huang Y.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 4
3
Content available remote

Changes in the vasoactive effects of nitric oxide, hydrogen sulfide and the structure of the rat thoracic aorta: the role of age and essential hypertension

84%
Berenyiova A., Drobna M., Cebova M., Kristek F., Cacanyiova S.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 4
4

Thyroid hormone dysfunctions affect the structure of rat thoracic aorta: a histological and morphometric study

84%
Zaki S. M., Youssef M. F.
Folia Morphologica
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2013
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tom 72
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nr 4
Background: There are limited data about the influence of hypothyroidism and hyperthyroidism on the connective tissue component and smooth muscle cells of the thoracic aorta. The aim was to study the histological changes of the wall of the thoracic aorta in the hypothyroid and hyperthyroid rats. Morphometric measurements were also done. Materials and methods: Thirty adult rats were used. They were divided into control, hyperthyroid, and hypothyroid groups. Each group consisted of 10 rats. The animals were sacrificed at the end of 8 weeks and the descending aorta was excised. Sections were stained with haematoxylin and eosin, orcein and Masson’s trichrome stains. The morphometric measurement included: number of smooth muscle cell nuclei, number of the elastic lamellae, thickness of the tunica media, elastic fibre optic density, and relative collagen area. Results: Atheromatous plagues had been observed in the hyperthyroid group. Thinning and rupture of the elastic lamellae had been observed in the hypothyroid group; these were accompanied with intimal ulceration and aortic dissection. The average number of smooth muscle cell nuclei in the hyperthyroid group had doubled and tripled compared to their fellows in the control and hypothyroid groups, respectively. The thickness of the tunica media increased in the hyperthyroid and hypothyroid groups by 75% and 35%. In addition, the relative collagen area increased in the previously mentioned groups by 142% and 120%, respectively. On the other hand, the mean elastic fibre optic density decreased in both groups by 30%. Conclusions: Structure wall affections of the intima and media of the descending aorta were associated with the thyroid hormone dysfunctions. These changes were more severe in the hypothyroid group. (Folia Morphol 2013; 72, 4: 333–339)
5
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High concentration of uric acid failed to affect endothelial function of small mesenteric arteries, femoral arteries and aortas from aged Wistar-Kyoto rats

84%
Balis P., Berenyiova A., Radosinska J., Kvandova M., Bernatova I., Puzserova A.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 3
6

The normal growth of the thoracic aorta in human foetuses

84%
Szpinda M.
Folia Morphologica
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2007
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tom 66
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nr 2
The present study was performed on 128 spontaneously aborted human foetuses aged 15–34 weeks in order to establish normal values for thoracic aorta dimensions at various gestational ages. Using anatomical dissection, digital-image analysis (the Leica QWin Pro 16 system) and statistical analysis (ANOVA, regression analysis) the growth of the length, the original and terminal external diameters and the volume of the thoracic aorta during gestation was examined. No significant gender differences were found (p > 0.05). The growth curves were generated of the best fit for the plot for each morphometric feature against gestational age. Both the length and external diameters of the thoracic aorta increased in proportion to the advance in foetal age. The length ranged from 12.49 ± 1.85 mm to 48.82 ± 6.31 mm according to the linear function y = –19.654 + 2.0512 x ± 3.5168. The original external diameter ranged from 1.25 ± 0.28 mm to 5.65 ± 0.48 mm according to the linear fashion y = –2.3834 + 0.2367 x ± 0.3850. The terminal external diameter ranged from 1.15 ± 0.26 mm to 5.18 ± 0.45 mm, in agreement with the linear model y = –2.1438 + 0.2156 x ± 0.3555 (r = 0.96, p < 0.001 for each feature). The volume of the thoracic aorta ranged from 15.75 ± 8.06 mm³ to 1158.01 ± 301.85 mm³ according to the quadratic function y = 1376.2 – 154.42 x + 4.419 x² ± 125.6 (R² = 0.90). The growth curves generated from my data may be useful as a reference for foetal echocardiographers, who must distinguish abnormal from normal foetal development.
7
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Effects of activated neutrophils on isolated rings of rat thoracic aorta

67%
Bauer V., Sotnikova R., Drabikova K.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 5
8
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Blood pressure-independent hypotrophy of the heart, kidneys and conduit arteries after 7-nitroindazole administration to Wistar rats from the prenatal period to adulthood

67%
Kristek F., Malekova M., Ondrias K., Cacanyiova S.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 1
9
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Effect of chronic neuronal nitric oxide-synthase inhibition on arterial function and structure in spontaneously hypertensive rats

67%
Cacanyiova S., Kristek F., Malekova M., Ondrias K.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 1
10
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Mantidis ootheca induces vascular relaxation through PI3K/Akt-mediated nitric oxide-cyclic GMP-protein kinase G signaling in endothelial cells

67%
Kim H. Y., Lee Y. J., Han B. H., Yoon J. J., Ahn Y. M., Hong M. H., Tan R., Kang D. G., Lee H. S.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 2
11
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Content available

Vascular changes in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet

67%
Lassila M., Santisteban J., Finckenberg P., Salmenpera P., Riutta A., Moilanen E., Virtanen I., Vapaatalo H., Nurminen M. L.
Journal of Physiology and Pharmacology
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2001
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tom 52
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nr 1
12
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Response of aorta connective tissue matrix to injury caused by vassopressin-induced hypertension or hypercholesterolemia

67%
Drobnik J., Dabrowski R., Szczepanowska A., Giernat L., Lorenc J.
Journal of Physiology and Pharmacology
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2000
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tom 51
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nr 3
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