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1

The ability of thiram to inhibit eukaryotic topoisomerase II and to damage DNA

100%
Rahden-Staron I., Czeczot H., Kowalska-Loth B.
Acta Biochimica Polonica
|
1993
|
tom 40
|
nr 1
2

Bacterial mutagenicity of dithiocarbamate fungicide thiram

88%
Rahden-Staron I., Czeczot H., Pienkowska M., Szymczyk-Wasiluk T.
Roczniki Państwowego Zakładu Higieny
|
1997
|
tom 48
|
nr 2
Looking for a mechanism of induction of chromosomal aberrations by thiram we checked its ability to damage bacterial DNA. Evaluation of the mutagenic effect of thiram was by: (i) the Salmonella!mammalian microsome Ames test with S. typhimurium TA102 strain, (ii) E. coli PQ37 strain to reveal an induction of the SOS response, (iii) test with E. coli BH20 fpg- and BH190 fpg-uvrA- mutants to check possible effect of modification of purines, (iv) test with E. coli AB1157 and AB1151 ada3 to detect DNA alkylation in 06 -position of guanine. The results of this work exclude DNA cross-links, oxidative damage of DNA, opening of imidazole ring in purines and events leading to activation of the SOS system as well as adaptive response as direct reasons of chromosomal abnormalities induced by thiram.
3
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Content available

Effect of vitamin D3-enriched diet on intestinal calcium absorption in rats intoxicated with carbaryl and thiram

63%
Witkowska D., Oledzka R., Sedrowicz L., Duliban D., Szelachowska M.
Polish Journal of Food and Nutrition Sciences
|
1992
|
tom 01
|
nr 4
4

Influence of thiram pretreatment on effects following intoxication of rats with fenitrothion

63%
Wysocka-Paruszewska B., Brzezinski J., Krajewska G., Szutowski M.
Acta Poloniae Toxicologica
|
2000
|
tom 08
|
nr 2
5

Cholinesterase activities in whole blood and brain of rats intoxicated with equitoxic mixture of fenitrothion and thiram

63%
Wysocka-Paruszewska B., Brzezinski J., Krajewska G.
Acta Poloniae Toxicologica
|
1999
|
tom 07
|
nr 2
6

Combined activity of thiram and lead acetate in Salmonella typhimurium tester strains

63%
Czeczot H., Zarnowiecka-Kokot A.
Acta Poloniae Toxicologica
|
1996
|
tom 04
|
nr 2
7

Wplyw tiuramu na osrodkowy uklad nerwowy u szczurow w tescie wielopokoleniowym

51%
Chruscielska K., Korzeniowski P., Sitowska B., Kalhorn D.
Bromatologia i Chemia Toksykologiczna
|
1995
|
tom 28
|
nr 4
331-338
Badanie oddziaływania tiuramu na ośrodkowy układ nerwowy prowadzono na potomstwie trzech pokoleń szczurów w okresie od 1 do 25 dnia życia postnatalnego. Ocenę neurotoksycznego efektu oparto o badania różnych form zachowania oraz oznaczania parametrów neurochemicznych (adrenalina, noradrenalina, dopomina, ceruloplazmina). Dane doświadczalne wskazują, że tiuram w stężeniu 400 mg/kg w paszy podawany szczurom w teście 3-generacji wywołuje zaburzenia funkcjonalne ośrodkowego układu nerwowego u potomstwa badanych pokoleń F1a, F2a oraz, że odchyleniom różnych form behawioru towarzyszą zmiany poziomu neurotransmiterów w tkance mózgowej.
8

Zanikanie 3H witaminy D3 z surowicy szczurow narazonych na dzialanie tiuramu

51%
Witkowska D., Sedrowicz L.
Bromatologia i Chemia Toksykologiczna
|
1995
|
tom 28
|
nr 4
323-329
Zanikanie 3H witaminy D3 w surowicy krwi badano na szczurach samcach szczepu Wistar narażonych na działanie tiuramu przez 2 tygodnie. W oparciu o otwarty model dwukompartmentowy wyznaczono podstawowe parametry farmakokinetyczne, tj. biologiczny okres póltrwania – t0,5, stałe szybkości dystrybucji (k12 i k21) oraz stalą eliminacji (k13).
9

Effect of thiram on calcium metabolism and vitamin D3 metabolites synthesis in rats

51%
Witkowska D., Sedrowicz L.
Acta Poloniae Toxicologica
|
1995
|
tom 03
|
nr 1
10

Morphological and cellular damage to some organs and changes in adrenocortical function parameters induced by equitoxic mixture fenitrothion-thiram in rats

51%
Wysocka-Paruszewska B., Kaminski M., Osicka-Koprowska A., Brzezinski J.
Acta Poloniae Toxicologica
|
2002
|
tom 10
|
nr 1
11

Effect of Carbendazim, imazetapir and thiram on nitrogenase activity, the number of microrganisms in soil and yield of red clover [Trifolium pratense L.]

51%
Niewiadomska A.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr 4
In field and pot experiments the effect of selected pesticides on the atmospheric nitrogen fixation, number of microorganisms in soil and yield of red clover has been investigated. The results obtained indicate that crop protection preparations applied in the experiments (Funaben T seed dressing compound and Pivot 100 SL herbicide) resulted in reduction of nitrogenase activity on the active strain of Rhizobium leguminosarum bv. trifolii KGL both in pot and field experiment conditions. Moreover, the authors observed the toxic effect of the pesticides used on nodulation, root development and yield of clover. The herbicide and fungicide applied also inhibited the multiplication of the microorganisms in soil under red clover plantations in the first days upon application and, later on, stimulated their multiplication.
12

Changes in lipoprotein lipase activity and plasma liver lipids in thiram intoxicated rats

51%
Sadurska B., Boguszewski B.
Acta Biochimica Polonica
|
1993
|
tom 40
|
nr 4
Acute thiram (tetramethyl-bls-thlocarbamyl disulphide) poisoning of rat (a single dose of 50% LDso) caused decreased lipoprotein lipase (LPL) activity in adipose tissue, the greatest inhibition being observed at 72 h after administration of the pesticide. Simultaneously, the levels of total plasma cholesterol, triacylglycerols and the high density lipoprotein (HDL) cholesterol were increased. On repeated pesticide administration (5% LDso) decreased LPL activity was observed after 14 and 30 days of poisoning, whereas after 90 days the LPL activity was distinctly increased. The levels of total cholesterol (in all periods of poisoning) and HDL cholesterol (only after 30 days of poisoning) became increased. These changes were accompanied by decreased content of free fatty acids and increase of hepatic triacylglycerols. The changes observed in the lipoprotein lipase activity of thiram-poisoned rats correspond to the profiles of plasma lipoproteins typical of thyroid hypofunction.
13
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Efficacy of selected seed dressings in protection of pasture grasses against Fusarium avenaceum [Fr.] Sacc.

51%
Golebniak B., Muszynska I.
Journal of Plant Protection Research
|
1999
|
tom 39
|
nr 2
In greenhouse experiments, the fungicides containing benomyl (Benlate 50 WP), thiram and carbendazim (Sarfun T 65 DS), or only thiram (Zaprawa Nasienna T Zawiesinowa) were the most effective in protection of meadow fescue, perennial ryegrass and Italian ryegrass against strongly pathogenic F. avenaceum isolate. The seed treatment fungicides containing an azole compound (Baytan Universal 19.5 DS, Premis 025 DS and Raxil 02 DS) showed low effectiveness. F. avenaceum infection of pasture grasses was not controlled by Polyversum biofungicide containing Pythium oligandrum oospores.
14

Effect of carbendazim, imazetapir and thiram on nitrogenase activity, number of microorganisms in soil and yield of hybrid lucerne [Medicago media]

51%
Niewiadomska A., Sawicka A.
Polish Journal of Environmental Studies
|
2002
|
tom 11
|
nr 6
In field and pot experiments the effect of selected pesticides on the nitrogenase activity, num­ber of soil microorganisms, and yield of hybrid lucerne was investigated. The obtained results show that crop protection preparations applied in the experiment (seed dressing compound Funaben T and Pivot 100SL herbicide) reduced the activity of nitrogenase in the active strain of Sinorhizobium me­liloti both under conditions of pot and field experiments. In addition, the authors observed a noxious influence of the applied pesticides on nodulation, root development and yield of lucerne. Furthermore, in the first days after their application, the employed herbicide and fungicide inhibited mul­ti­pli­cation of soil microorganisms under lucerne plantations, while later they were found to stimulate their mul­ti­pli­cation.
15

Wplyw diety o zwiekszonej zawartosci witaminy B6 na wchlanianie aminokwasow w jelicie szczurow narazonych na karbaryl,propoksur i tiuram.Cz.2 Leucyna

45%
Witkowska D., Sedrowicz L., Oledzka R.
Bromatologia i Chemia Toksykologiczna
|
1992
|
tom 25
|
nr 1
31-36
Carbaryl, propoksur, and thiuram were administered for 14 days, by a stomach tube, at dosing level corresponding to 5% LD50 , to male Wistar rats four weeks old and fed a diet enriched with vitamin B6 (200 µg/day). Active and passive leucine transport in rat intestine was studies using liquid scintillation method according to Patrick and Papworth, modified by the authors. No disorder of leucine transport was observed in animals exposed to carbaryl and propoksur, and fed a diet enriched with vitamin B6. No disturbances were also noted in subject exposed to thiuram, except that Jm constans was increased by about 170% when compared with the control, and the affinity was decreased (rise of Kt constant by 320%). However, it seems that the diet enriched with vitamin B6, may protect amino acids homeostasis in animals exposed to some xenobiotics.
16

Badania oddzialywania karbarylu,propoksuru i tiuramu na metabolizm fosforanowy u szczurow

45%
Witkowska D., Oledzka R., Garszel J.
Bromatologia i Chemia Toksykologiczna
|
1993
|
tom 26
|
nr 4
217-224
W badaniu jednorazowym i wielokrotnym wykazano zmiany w transporcie i kumulacji fosforu w jelicie oraz w jego wydalaniu z moczem w wyniku narażenia na karbaryl, propoksur i tiuram.
17

Wpływ zapraw zawierających fludioksonil, karboksynę z tiuramem i tebukonazol na wzrost pszenicy we wczesnych fazach rozwojowych

45%
Kubiak K.
Progress in Plant Protection
|
2010
|
tom 50
|
nr 4
A laboratory experiment was performed on three winter wheat cultivars: Legenda, Sukces and Zyta. Seeds were treated with Maxim 025 FS (fludioxonil), Vitavax 2000 FS (carboxin and thiram) and Zaprawa zbożowa Orius 060 FS (tebuconazole). Treated seeds were incubated for 14 days on Petri dishes in temperature 20°C. The following parameters were evaluated: length and fresh weight of shoot, length and fresh weight of root and number of primary roots. In most cases no significant differences in evaluated winter wheat growth parameters were stated between seed treatments and untreated object. However, some tendencies concerning applied seed treatments could be observed. After the application of seed treatment containing carboxin and thiram (Vitavax 2000 FS) the shoot length on all cultivars was the highest in comparison to untreated object and other seed treatments. The root length and weight was mostly the lowest. After the application of seed treatment containing fludioxonil (Maxim 025 FS) root length on all cultivars was the highest as compared to the other objects. The root weight was lower than in untreated object. The number of primary roots was mostly the lowest in comparison to untreated object and other seed treatments. After the application of seed treatment containing tebuconazole (Zaprawa zbożowa Orius 060 FS) the root weight and number of primary roots of all cultivars was the highest in comparison to untreated object and other seed treatments. The shoot weight was mostly the highest.
18

Ochronny wplyw N-acetylocysteiny na prooksydacyjne i proapoptotyczne dzialanie tiuramu w komorkach V79 chomika chinskiego

45%
Kurpios-Piec D., Grosicka-Maciag E., Czeczot H., Szumilo M., Grzela T., Rahden-Staron I.
Bromatologia i Chemia Toksykologiczna
|
2010
|
tom 43
|
nr 3
354-361
19

Wplyw diety o zwiekszonej zawartosci witaminy B6 na wchlanianie aminokwasow w jelicie szczurow narazonych na karbaryl,propoksur i tiuram.Cz.1 Metionina

45%
Witkowska D., Sedrowicz L., Oledzka R.
Bromatologia i Chemia Toksykologiczna
|
1992
|
tom 25
|
nr 1
25-30
Alimentary rations under test were found to be rich in fat. Fat energy proportional portion exceeded, as a rule, the recommended value by about 30%. At the same time, acidic composition of fat under test was wide of the optimal one. Predominant group was saturated and monounsaturated acids (occurring in similar amounts), however, polyunsaturated acids content amounted to about 11 % of total fatty acids sum. Energy proportional portion from essential fatty acids, in a whole day's rations, was found to be higher than necessary minimum (3%); on the other hand, it did not cover the recommended standard for subjects advanced in years (4%). Value P:S was noted to correspond with an average european diet. Portion of acids with proaggregative properties was higher than hypercholesteremic acids content.
20

Wplyw diet o roznej zawartosci bialka na wybrane parametry metabolizmu wapniowo-fosforanowego u szczurow narazonych na dzialanie pestycydow. Cz.I. Tiuram

38%
Witkowska D.
Bromatologia i Chemia Toksykologiczna
|
1996
|
tom 29
|
nr 4
343-352
Badano wpływ wielokrotnego narażenia na tiuram (4 tygodnie) w dawce 5% LD50, na transport wapnia i fosforu w jelicie oraz stężenie tych pierwiastków w surowicy i kości udowej szczurów karmionych dietami o różnej zawartości białka (7,5%, 10,3%, 22,7% - dieta standardowa i 30,6%).
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