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1

Concentration of TBA-reactive substances in type II pneumocytes exposed to oxidative stress

100%
Piotrowski W. J., Marczak J., Kurmanowska Z., Gorski P.
Archivum Immunologiae et Therapiae Experimentalis
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2004
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tom 52
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nr 6
2

The role of selected antioxidants in the process of red cell oxidation

100%
Kleszczynska H., Kilian M., Przestalski S., Witek S.
Biophysics of Membrane Transport
|
1994
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tom 12
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nr 2
3
Content available remote

Effects of extremely low frequency magnetic field on the parameters of oxidative stress in heart

84%
Goraca A., Ciejka E., Piechota A.
Journal of Physiology and Pharmacology
|
2010
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tom 61
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nr 3
333-338
Increasing production of free radicals in organisms is one of the putative mechanisms by which a extremely low frequency magnetic field (ELF-MF) may affect biological systems. The present study was designated to assess if ELF-MF applied in the magnetotherapy, affects generation of reactive oxygen species (ROS) in heart tissue and antioxidant capacity of plasma according to its working time. The experiments were performed on 3 groups of animals: group I - control; group II - exposed to 40 Hz, 7 mT, 30 min/day for 14 days (this field is commonly applied in magnetotherapy); group III - exposed to 40 Hz, 7 mT, 60 min/day for 14 days. Control rats were housed in a separate room without exposure to ELF-MF. Immediately after the last exposure, blood was taken from the tail vein and hearts were removed under anesthesia. The effect of the exposure to ELF-MF on oxidative stress was assessed on the basis of the measurements of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide (H2O2), total free sulphydryl groups (-SH groups) and reduced glutathione (GSH) concentrations in heart homogenates. The total antioxidant capacity of plasma was measured using ferric reducing ability method (FRAP). Exposure to ELF-MF (40 Hz, 7 mT, 30 min/day for 2 weeks) did not significantly alter tissue TBARS, H2O2, total free -SH groups, reduced glutathione (GSH) and total antioxidant capacity of plasma. By contrast, ELF-MF with the same frequency and induction but used for 60 min/day for 14 days caused significant increase in TBARS and H2O2 concentration (P<0.01) and decrease in the concentration of GSH (P<0.05) and total free -SH groups in heart homogenates. Moreover, exposure of rats to ELF-MF (40 Hz, 7 mT, 60 min/day for 2 weeks) resulted in the decrease of plasma antioxidant capacity. Our results indicate that effects of ELF-MF on ROS generation in the heart tissue and antioxidant capacity of plasma depend on its working time.
4

An assessment of fat substitution with buckwheat seed preparation on the quality of comminuted meat products

84%
Dolatowski Z. J., Karwowska M.
Electronic Journal of Polish Agricultural Universities. Series Food Science and Technology
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2006
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tom 09
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nr 4
5

The effects of feeding with different levels of zinc and chromium on plasma thiobarbituric acid reactive substances and antioxidant enzymes in rats

84%
Esen Gursel F., Tekeli S. K.
Polish Journal of Veterinary Sciences
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2009
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tom 12
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nr 1
This study was designed to investigate the effects of supplementation and deficiency of dietary chromium (Cr), zinc (Zn) and combination of zinc and chromium on lipid peroxidation and antioxidant enzymes. A total of 84 male Wistar albino rats were fed rat chow containing different levels of Zn and Cr throughout the 84 days. Blood samples were collected for analysis of Thiobarbituric acid reactive substances (TBARS), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px). TBARS concentrations in rats fed high-Cr diet, high-Zn and Cr diet and low-Zn diet were significantly higher than those determined in the control group (p ≤ 0.05). CAT activities in rats fed high-Cr diet were significantly higher than those observed in the control group. Cu-Zn SOD and GSH-Px activities were significantly higher in rats fed high-Cr diet, high-Zn and Cr diet, low-Zn diet, and low-Zn and Cr diet when compared to the activities found in the controls. These results suggest that trivalent chromium supplementation increase antioxidant enzymes by enhancement of lipid peroxidation, but Zn supplementation does not have any effect on lipid peroxidation. Also Zn deficiency resulted in increased lipid peroxidation, SOD and GSH-Px activities because of the oxidative stress caused by zinc deficiency.
6

Liver and serum antioxidant status after methanol intoxication in rats

84%
Skrzydlewska E., Farbiszewski R.
Acta Biochimica Polonica
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1997
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tom 44
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nr 1
Activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-R) and concentration of ascorbate, a-tocopherol, non-protein and protein-bound sulfhydryi compounds and thio- barbituric acid-reactive substances (TBA-rs) were measured in liver and serum of rats 6, 12 and 24 h and 2, 5 and 7 days after intoxication with 1.5 g or 3.0 g methanol/kg b.w. Liver GSH-Px and GSSG-R activities and SH-groups and ascorbate content were significantly diminished at 6 and 24 h, while TBA-rs were increased. Serum SOD, GSH-Px and GSSG-R activities and SH-groups concentration were reduced while TBA-rs were elevated. The changes were more intensive after application of the higher dose of methanol. It is concluded that methanol impairs the liver and blood serum antioxidant mechanisms in rats.
7
Content available remote

Effects of extremely low frequency magnetic field on oxidative balance in brain of rats

67%
Ciejka E., Kleniewska P., Skibska B., Goraca A.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 6
8
Content available remote

Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice

67%
Niemiec T., Sikorska J., Harrison A., Szmidt M., Sawosz E., Wirth-Dzieciolowska E., Wilczak J., Pierzynowski S.
Journal of Physiology and Pharmacology
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2011
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tom 62
|
nr 1
The objective of this study was to evaluate the effect of -ketoglutarate on redox state parameters and arterial elasticity in elderly mice. Mice in the control group were fed with standard diet, while the experimental animals received the diet supplemented either with calcium (Ca-AKG) or sodium salt of -ketoglutarate (Na-AKG). The experimental animals were divided into 4 groups with 10 individuals in each: control I (12 months old), control II (2 months old), experimental group I fed with Ca-AKG (12 months old) and experimental group II fed with Na-AKG (12 months old). Mice treated with Ca-AKG as well as the control II animals demonstrated significantly higher level of total antioxidant status (TAS), comparing to the control I animals and those treated with Ca-AKG. Thiobarbituric acid reactive substances (TBARS) level in blood plasma was found significantly lower in young and Ca-AKG treated mice. TBARS liver concentration was significantly different in each examined group. The study also demonstrates the decrease in TBARS level in Ca-AKG treated animals. Treatment with Na-AKG significantly increased glutathione peroxidase activity and decreased the activity of superoxide dismutase. The presented results suggest that Ca-AKG protects the organism against the free radicals related elderly processes. The study presents also the effect of Ca-AKG treatment on arterial elastic characteristics in elderly mice. The beneficial effect of Ca-AKG on ageing organisms was confirmed via redox state stabilization and blood vessel elasticity improvement.
9

The effects of dietary whey protein concentrate level on performance, selected intestinal tract and blood parameters, and thiobarbituric acid reactive substances in the liver and breast meat of broiler chickens

67%
Szczurek W., Szymczyk B., Arczewska-Wlosek A., Jozefiak D., Alloui M. N.
Journal of Animal and Feed Sciences
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2013
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tom 22
|
nr 4
The aim of this study was to investigate the effect of two levels of whey protein concentrate (WPC, 80.35% protein, 5.86% lactose) added to diets and duration of these treatments on growth and slaughter value, haematological parameters involved in immune processes, oxidative status of liver and breast muscle, and selected indices of gut function of broilers. A total of 560 Ross 308 broilers were randomly allocated into 7 groups with 10 replicates of 8 chickens per replicate. The experiment lasted 42 days and was divided into 3 successive feeding phases. The control group was fed basal diets consisted of maize, wheat and soyabean meal (C group). The other 6 groups received, for 7, 21 and 42 days basal diets with 8 or 32 g · kg–1 WPC added at the expense of soyabean meal (WL and WH groups, respectively). On day 42 group WH had a higher lymphocyte percentage (P < 0.05) compared to the control. The long-term (42 days) feeding with higher level of WPC significantly decreased the heterophile/lymphocyte ratio (P < 0.05 vs C). The number of erythrocytes on day 42 and the whole blood glucose on day 21 were significantly increased in WH birds than in controls. The concentration of serum total protein on both WPC levels was greater (P < 0.05) on day 21 compared with the C group. The reduction (P < 0.05) in liver thiobarbituric acid reactive substances (TBARS) and a tendency towards lower TBARS level in breast meat were observed in birds WH when fed for 42 days. Only higher dietary WPC amount provided for 42 days reduced the caecal and small intestinal pH values (P < 0.05 vs C). The ileal digestibility of crude protein was higher (P < 0.01) in birds fed with 32 g WPC during the first 21 days of life, compared to the C and WL treatments. The factorial ANOVA showed that on days 7, 21 and 42 the final body weight gain (BGW) and feed conversion ratio in broilers WL and WH were significantly better than in the C ones. Assessment of orthogonal contrasts revealed significantly higher (P < 0.05) final BWG in the WH broilers, compared to the WL dietary treatment; such effect was not observed in earlier feeding stages. Generally, carcass yield on both WPC dietary levels, and breast muscle percentage on WH treatment, were higher (P < 0.01 and P < 0.05, respectively) compare to the C group. In conclusion, WPC added to a conventional diets for growing chickens exerts a growth-promoting action and at a dose of 32 g · kg–1 may induce desirable changes in bird’s health and the intestinal tract metabolism.
10
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Content available

Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezinc

67%
Nishiwaki H., Kato S., Sugamoto S., Umeda M., Morita H., Yoneta T., Takeuchi K.
Journal of Physiology and Pharmacology
|
1999
|
tom 50
|
nr 2
11
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats

67%
Konaka A., Nishijima M., Tanaka A., Kunikata T., Kato S., Takeuchi K.
Journal of Physiology and Pharmacology
|
1999
|
tom 50
|
nr 1
12
Content available remote

Sesbania grandiflora diminishes oxidative stress and ameliorates antioxidant capacity in liver and kidney of rats exposed to cigarette smoke

59%
Ramesh T., Sureka C., Bhuvana S., Hazeena Begum V.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 4
467-476
Cigarette smoke is a major risk factor for many chronic diseases. However, it may be possible to relieve the smoke-induced damage by increasing the defensive system. In this study, we planned to evaluate the protective mechanism of Sesbania grandiflora (S. grandiflora) leaves against cigarette smoke-induced oxidative damage in liver and kidney of rats. Adult male Wistar-Kyoto rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with S. grandiflora aqueous suspension (SGAS, 1000 mg/kg body weight per day by oral gavage) for a period of 3 weeks. Hepatic marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), as well as renal markers such as urea and creatinine were analysed in serum. Lipid peroxidation marker mainly thiobarbituric acid reactive substances (TBARS) and antioxidant enzymes namely superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) activities and non-enzymatic antioxidants such as reduced glutathione, ascorbic acid and a-tocopherol levels were studied. In addition, micronutrients mainly copper (Cu), zinc (Zn), manganese (Mn) and selenium (Se) levels were analyzed in liver and kidney of rats exposed to cigarette smoke. The results indicated that SGAS significantly decreased the elevated hepatic, renal and lipid peroxidation markers and ameliorated the diminished antioxidant levels while restored the hepatic and renal architecture in cigarette smoke-exposed rats. This study concludes that S. grandiflora leaves restrain cigarette smoke-induced oxidative damage in liver and kidney of rats.
13

Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl

51%
Ponist S., Mihalova D., Jancinova V., Snir V., Ondrejickova O., Mascia C., Poli G., Stancikova M., Nosal R., Bauerova K.
Acta Biochimica Polonica
|
2010
|
tom 57
|
nr 2
The aim of this study was to evaluate the therapeutic potential of oxidative stress (OS) reduction by using pyridoindole (PI) antioxidants in adjuvant arthritis (AA). The substances tested were stobadine dipalmitate (STB) and SMe1. AA was used as animal model. The experiments included healthy animals, control arthritic animals and arthritic animals with administration of PI in the oral daily dose of 15 mg/kg b.m during 28 experimental days. The rats were sacrificed on day 28. Clinical and biochemical parameters were determined. The effect of PI administration was evaluated on the basis of the following parameters: (a) arthritis (volume of hind paws - HPW, change of animal body mass - CBM), (b) OS (chemiluminescence of whole blood - CWB, levels of thiobarbituric acid reacting substance - TBARS and of HNE- and MDA-protein adducts in plasma and activity of γ-glutamyltransferase (GGT) in hind paw joint homogenates). The PI studied significantly increased the CBM of animals and corrected the HPW. STB also significantly decreased the activity of GGT in joint homogenates. SMe1 was more effective in decreasing plasmatic TBARS levels, but STB was more effective in reducing plasmatic HNE- and MDA-protein adducts. The assay for HNE- and MDA-adducts in plasma as a function of time was applied for the first time in AA. STB markedly decreased spontaneous and PMA-stimulated CWB and reduced neutrophil count. In summary, STB was more effective than SMe1 in reducing OS in AA. Our results showed that the reduction of OS in arthritis also corrected the clinical manifestations of the disease.
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