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1

In vitro studies of the effect of theophylline and/or N-acetylcysteine on redox homeostasis and ketogenesis in rat hepatocytes

100%
Stec M., Kurzeja E., Gawel S., Wardas P., Maciejewska=Paszek I., Pawlowska-Goral K.
Bulletin of the Veterinary Institute in Puławy
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2011
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tom 55
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nr 3
The examinations were conducted on hepatocvtes isolated by means of enzymatic method from the liver of three-month-old Wistar rats. The cells were incubated in medium with addition of theophylline and/or N-acetylcysteine. Significant changes in the activity of SOD, GPx, and GR in hepatocvtes incubated in the presence of the compounds in comparison with control cells demonstrated that theophylline and/or N-acetylcysteine disturb oxidative-reductive homeostasis of the cells. Changes in concentrations of ketone bodies, resulting in disturbances of acetoacetate to ß-hydroxybutyrate molar ratio, point to an unfavourable interference of theophylline into ketogenesis, which is equivalent with the disturbance of the balance between NAD⁺ and NADH+H⁺ in hepatocvtes. N-acetylcysteine simultaneously present with theophylline in incubation medium exerted a protective action on ketogenesis.
2
Content available remote

Chronic obstructive pulmonary disease: an update on nuclear signaling related to inflammation and anti-inflammatory treatment

100%
Mroz R. M., Holownia A., Chyczewska E., Braszko J. J.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
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nr 6
35-42
3

Changes of cellular cAMP level in Tetrahymena during starvation and conjugation

100%
Yu Y. H., Xiang X., Wu D., Chen Y.
Acta Protozoologica
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1993
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tom 32
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nr 2
4

Influence of theophylline on interferon production and cAMP level in Lpa cells

100%
Zahorska R., Korbecki M., Barciszewski J.
Archivum Immunologiae et Therapiae Experimentalis
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1995
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tom 43
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nr 1
5

Methylxanthines [caffeine, pentoxifylline and theophylline] decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone

100%
Piosik J., Gwizdek-Wisniewska A., Ulanowska K., Ochocinski J., Czyz A., Wegrzyn G.
Acta Biochimica Polonica
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2005
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tom 52
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nr 4
Previously performed experiments showed that methylxanthines, especially caffeine, may protect cells against cytostatic or cytotoxic effects of several aromatic compounds. One of the proposed mechanisms of this protection is based on stacking interactions between π electron systems of polycyclic aromatic molecules. In this work, we demonstrate that caffeine and other methylxanthines  -  pentoxifylline and theophylline - significantly decrease mutagenicity of the anticancer aromatic drugs daunomycin, doxorubicin and mitoxantrone. The spectrophotometric titration of these aromatic compounds by methylxanthines indicated formation of mixed aggregates. The concentrations of free active forms of the drugs decreased when the concentrations of methylxanthines increased in the mixture. Therefore, likely methylxanthines may play a role of scavengers of the free active forms of daunomycin, doxorubicin and mitoxantrone.
6
Content available remote

Studies of phosphodiesterase effects on adipose tissue metabolism in obese subjects by the microdialysis technique

100%
Flechtner-Mors M., Jenkinson C. P., Alt A., Biesalski H. K., Adler G., Ditschuneit H. H.
Journal of Physiology and Pharmacology
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2005
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tom 56
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nr 3
The effect of non-selective (theophylline) inhibition of cyclic AMP breakdown on norepinephrine stimulated lipolysis rate was investigated in subcutaneous adipose tissue of obese subjects. In addition, changes in interstitial glucose and lactate concentration were assessed by means of the microdialysis technique. The interaction of endogenous released insulin and theophylline on adipocyte metabolism was determined. Theophylline and norepinephrine alone increased glycerol outflow significantly. When both agents were perfused in combination, interstitial glycerol concentration increased further. The enhanced glycerol level due to theophylline application was slightly decreased by insulin. In the presence of theophylline, extracellular glucose concentration increased, in contrast to the catecholamine. Norepinephrine decreased interstitial glucose level. When both drugs were added in combination, the level of interstitial glucose increased to about 1 mM, greater than with theophylline alone. With each intervention, lactate was synthesized. Local adipose tissue blood flow was increased by theophylline and theophylline plus norepinephrine. In conclusion, post-receptor mechanisms increased norepinephrine maximal stimulated lipolysis rate in subcutaneous adipose tissue. Glucose uptake was inhibited by the non-specific inhibitor of phosphodiesterase. The effect of insulin on inhibition of lipolysis was modest but sustained in the presence of high theophylline (10-4 M) concentration. Phosphodiesterase activity may be relatively low in obese subjects in comparison with lean subjects. In lean subjects theophylline caused a transient reversal of the antilipolytic effect of insulin.
7
Content available remote

Influence of xanthine derivatives on cough and airway reactivity in guinea pigs

80%
Mokry J., Nosalova G., Mokra D.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 5
8
Content available remote

Teophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition

80%
Chorostowska-Wynimko J., Kus J., Skopinska-Rozewska E.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
9
Content available remote

Molecular basis of chronic inflammation in lung diseases: new therapeutic approach

80%
Mroz R. M., Noparlik J., Chyczewska E., Braszko J. J., Holownia A.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
10

Effect of domperidone-induced hyperprolactinemia on selected immune parameters in healthy women

80%
Rovensky J., Buc M., Lojda Z., Ruzickova M., Blazickova S., Rauova L., Mistina T., Vigas M., Lackovic V.
Archivum Immunologiae et Therapiae Experimentalis
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1995
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tom 43
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nr 3-4
11

Herbata - korzystny skladnik diety

51%
Kolanowski W.
Żywność, Żywienie a Zdrowie
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1997
|
tom 06
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nr 4
353-356
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