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The antiproliferative action of [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P analogue antagonist against small cell- and non-small-cell lung cancer cells could be due to the pharmacological profile of its tachykinin receptor antagonist

100%

Munoz M., Recio S., Rosso M., Redondo M., Covenas R.

Journal of Physiology and Pharmacology

2015

tom 66

nr 3

The potential implication of neurokinin B in the modulation of prolactin secretion at the pituitary level in cyclic gilts

100%

Czelejewska W., Zmijewska A., Dziekonski M., Okrasa S.

Journal of Physiology and Pharmacology

2020

tom 71

nr 2

Role of tachykinin receptors and melatonin in oxytocin secretion from isolated rat hypothalamo-neurohypophysial system

100%

Juszczak M., Furykiewicz-Nykis K., Stempniak B.

Journal of Physiology and Pharmacology

2004

tom 55

nr 4

Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system as well as to determine whether the tachykinin NK-1 and/or NK-2 receptors contribute to the response of oxytocinergic neurons to melatonin. The results show, for the first time, that highly selective NK-1 receptor agonist, i.e., [Sar9,Met(O2)11]-Substance P, enhances while the NK-1 receptor antagonist (Tyr6,D-Phe7,D-His9)-Substance P (6-11) - sendide - diminishes significantly OT secretion; the latter peptide was also found to antagonize the substance P-induced hormone release from isolated rat H-N system, when used at the concentration of 10-7 M/L. Melatonin significantly inhibited basal and substance P-stimulated OT secretion. Neurokinin A and the NK-2 receptor selective agonist (ß-Ala8)-Neurokinin A (4-10) as well as the NK-2 receptor antagonist (Tyr5,D-Trp6,8,9, Lys-NH210)-Neurokinin A (4-10) were essentially inactive in modifying OT release from the rat H-N system in vitro. The present data indicate a distinct role for tachykinin NK-1 (rather than NK-2) receptor in tachykinin-mediated regulation of OT secretion from the rat H-N system. Under present experimental conditions, however, a role of respective tachykinin receptors in the response of oxytocinergic neurons to melatonin has not been found.

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Covenas R.

1 Czelejewska W.

1 Dziekonski M.

1 Furykiewicz-Nykis K.

1 Juszczak M.

1 Munoz M.

1 Okrasa S.

1 Recio S.

1 Redondo M.

1 Rosso M.

1 Stempniak B.

1 Zmijewska A.

1 2020

1 2015

1 2004

Wyniki wyszukiwania

The antiproliferative action of [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P analogue antagonist against small cell- and non-small-cell lung cancer cells could be due to the pharmacological profile of its tachykinin receptor antagonist

The potential implication of neurokinin B in the modulation of prolactin secretion at the pituitary level in cyclic gilts

Role of tachykinin receptors and melatonin in oxytocin secretion from isolated rat hypothalamo-neurohypophysial system