Wyniki wyszukiwania

1

A study on urinary salt discharge and stomach cancer mortality

100%

Ooi E., Natsukawa S., Matsushima S.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

2

Cancer procoagulant as a marker using for monitoring of oesophageal, stomach and colorectal cancer therapy

88%

Kozuszko B., Skrzydlewska E., Snarska J., Kozlowski M., Zalewski B., Skrzydlewski Z.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

3

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Magnesium concentration in plasma and tissues of patients undergoing surgery for stomach and large intestine cancer

63%

Szewczyk M., Pasternak K., Andrzejewski A., Dabrowski A., Wallner G.

Journal of Elementology

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2009

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tom 14

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nr 3

563-571

Digestive system neoplasms pose a serious health problem both in Poland and abroad. Neoplasms are frequently considered to be caused by impaired homeostasis in the human body. Development of neoplasms may be linked to disturbances in concentration of elements, including magnesium as a major intracellular cation. The objective of this study was to evaluate the concentration of magnesium in plasma and tissue samples taken from patients suffering from neoplasms of the stomach or the large intestine. The study involved 35 patients, including 20 affected by stomach cancer and 15 suffering from large intestine cancer. The patients were in the age rage of 36-77. The material included blood samples taken from patients before and seven days after surgery, as well as samples of cancerous and healthy tissues. The colorimetric method with a Genesis spectrophotometer was used for determination of magnesium concentration. A statistically significant difference was observed between plasma magnesium concentration in patients affected by stomach cancer and the normal range. Elevated values of magnesium concentration measured on the seventh day after the procedure as compared to the concentration before the procedure was noted, however, the difference was statistically insignificant. No significant differences were observed in magnesium concentration measured before and after the procedure, or in comparison to the normal range in patients with large intestine cancer. Determination of tissue magnesium showed that magnesium concentration was higher in cancerous than in healthy tissue. Obtained results demonstrate that magnesium homeostasis is impaired in patients, which may be important in the pathoghenesis of digestive system neoplasms.

4

Contribution of epidemiology in Poland for better understanding of the natural history of diseases in gastrointestinal tract

63%

Jedrychowski W.

Journal of Physiology and Pharmacology. Supplement

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2003

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tom 54

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nr 3

245-261

Descriptive epidemiologic studies on the geographical distribution of gastrointestinal diseases in Poland have been conducted in our country since several decades. One of the first descriptive analyses was cancer study in 1967, where age-standardized mortality rates in various regions of Poland by gender and area of residence (urban/rural) were presented. Since 1970 analytical epidemiologic studies aiming at explaining the natural course of various diseases within gastrointestinal tract started to produce interesting results. The first study in this field was the case-control study on the occurrence of peptic ulcer and tobacco smoking performed in 1974. The study provided one of the first epidemiologic evidence on the harmful effect of tobacco smoking in the etiology or peptic ulcers. Subsequent studies dealt with the importance of dietary habits and life style (tobacco smoking and vodka drinking) in the occurrence of gastric cancer. The studies confirmed previous findings that consumption of raw vegetables and fresh fruit is inversely related to risk for stomach cancer in Poland. In addition the results demonstrated, that dietary practices such as the modality of cooking the food, preparation of food products and storing conditions were connected with stomach cancer risk. These factors have also been found to influence the risk for stomach cancer in Poland. The main message of this latter study was that the family as a whole is affected by many risk factors for stomach cancer and families in which stomach cancer has occurred should be therefore targets for preventive measures. Interestingly, analysis of life style factors such as tobacco smoking or vodka drinking has showed that the risk for cardia cancer increased considerably for smokers of cigarettes without filters and in those who consumed large amounts of vodka. For the non-cardia region a uniform increase of risk could be observed for vodka drinking, regardless of cigarette smoking status. The findings of this study suggested the hypothesis that the effect of tobacco smoking and vodka drinking may be different for cardia cancer compared to the distal cancers. Our clinico-epidemiological study suggest that infection with Helicobacter pylori is not sufficient factor for inducing precancer changes in gastric mucosa. Besides, case-controls studies on dietary habits and physical activity level in the etiology of colorectal cancer are in progress. The preliminary results demonstrated the protective effect of higher physical activity in the occurrence of colorectal cancer after accounting for nutritional habits.

5

Usufulness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis

63%

Talar-Wojnarowska R., Gasiorowska A., Smolarz B., Romanowicz-Makowska H., Strzelczyk J., Janiak A., Kulig A., Malecka-Panas E.

Journal of Physiology and Pharmacology. Supplement

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2004

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tom 55

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nr 2

129-138

The differentiation of chronic pancreatitis (CP) from pancreatic adenocarcinoma (PA) remains a great challenge. The purpose of the study was to compare the prevalence of p16 and K-ras mutation in PA and CP in order to evaluate their usefulness in differential diagnosis of those diseases. Methods: The study included 44 patients who underwent Whipple resection or distal pancreatectomy for PA (23 subjects) or CP (21 subjects). DNA from pancreatic tissue was analysed for K-ras mutation (codon 12) and p16 mutations with PCR amplifications. Results: The K-ras gene mutation has been shown in 17 (73,9%) cases with pancreatic adenocarcinoma which was significantly more often than in chronic pancreatitis - 9 (42,8%) (p<0,01). Prevalence of p16 mutations in patients with PA was 18 (78,3%) and with CP - 7 (33,3%) (p<0,01). K-ras and p16 mutations together have been observed in 16 (69,6%) cases in patients with PC and only in 3 (14,3%) - with CP (p<0,01). No statistically significant association between K-ras or p16 mutations and tumor size, sex or patient age has been observed. Conclusion: It is suggested that simultaneous measurement of K-ras and p16 mutations may provide an additional tool in differential diagnosis of chronic pancreatitis and pancreatic adenocarcinoma.

6

ERK is involved in the differentiation induced by diallyl disulfide in the human gastric cancer cell line MGC803

63%

Ling H., Zhang L., Su Q., Song Y., Luo Z., Zhou X. T., Zeng X., He J., Tan H., Yuan J.

Cellular and Molecular Biology Letters

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2006

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tom 11

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nr 3

Diallyl disulfide (DADS) is a major constituent of garlic. Previously, we found that DADS both inhibited proliferation in human gastric cancer cells in vitro and in vivo, and induced G2/M arrest. In this study, we investigated whether this differentiation effect was induced by DADS in human gastric cancer MGC803 cells, and whether it was related to an alteration in ERK activity. The results showed that the growth of MGC803 cells was inhibited by DADS. Cells treated with DADS displayed a lower nucleocytoplasmic ratio and tended to form gland and intercellular conjunction structures. The ConA-mediated cell agglutination ratio and cells’ ALP specific activity decreased. In MGC803 cells, dye transfer was limited to a few cells neighbouring the dye-injected cell and to a depth of 1–2 layers beneath the scrape site. However, after treatment with DADS, the LY (Lucifer Yellow) was transferred to several cells immediately neighbouring the microinjected cell and to a depth of 2–4 cell layers from the scrape site. This indicated that DADS induced differentiation in MGC803 cells. Western blot analysis revealed that although DADS did not influence the quantity of ERK1/2 protein expressed, it did decrease its phosphorylation in a concentration-dependent manner, compared with the controls. At 30 mg·L−1, DADS inhibited the activation of ERK1/2 in 15–30 min. These results suggested that the DADS-induced differentiation of MGC803 cells involved an alteration of the ERK1/2 signaling pathway.

7

Professor Ludwik Rydygier father and legend of Polish surgery

51%

Bielecki K.

Journal of Physiology and Pharmacology

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2011

|

tom 62

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nr 1

Ludwik Rydygier is undoubtedly the father of Polish gastrointestinal surgery. He performed two pioneering stomach operations: on 16 November 1880, first in Poland and second in the world after Jules Pean, the surgical removal of the pylorus in a 64-year-old patient suffering from stomach cancer; the operation took about four hours, unfortunately the patient died 12 hours later, and on 21 November 1881 he performed the world’s first pylorectomy due to gastric ulcer, applying his own method of pylorectomy followed by the restoration by end-to-end anastomosis of the duodenal stump with the stomach stump; the patient survived the operation and recovered. Three years later, Rydygier introduced a new method of surgical treatment of peptic ulcer disease by means of gastroenterostomy. This review was designed to commemorate the outstanding achievements of Professor Rydygier, who worked at two universities: at the Jagiellonian University in Cracow, and at the Lemberg (Lviv) University. He was one of the founders of the Association of Polish Surgeons and an organizer of the first Meeting of Polish Surgeons in 1889. He was the author of over 200 published papers and several text-books on surgical infections, surgical techniques, orthopaedics and traumatology, urology, neurosurgery, and gynaecology. Professor Ludwik Rydygier possessed comprehensive knowledge of surgery and other medical disciplines, he was a courageous surgeon and skilled operator, being at the same time an extremely gifted organizer. His promotion to the rank of General of Polish Army crowned his credits for country’s defence. At the anniversary of 90 years after his death, Polish surgeons pay the tribute to their mentor.

8

Stomach wall changes caused by the presence of third-stage Anisakis simplex B larvae in infected dogs

51%

Podolska M., Piusinski W., Rokicki J.

Acta Parasitologica

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1997

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tom 42

|

nr 4

Samples of stomach fundus and pylorus tissue collected from eight dogs experimentally infected with third-stage A. simplex В larvae were examined macro- and microscopically. The histopathological changes in these samples were analysed. Pathomorphological examination revealed that A. simplex В larvae actively penetrated the dog’s stomach wall within 2 days of infection. The presence of larvae in the mucous membrane was accompanied by tissue damage and cell infiltration predominantly by eosinophils.

Ograniczanie wyników

A study on urinary salt discharge and stomach cancer mortality

Cancer procoagulant as a marker using for monitoring of oesophageal, stomach and colorectal cancer therapy

Magnesium concentration in plasma and tissues of patients undergoing surgery for stomach and large intestine cancer

Contribution of epidemiology in Poland for better understanding of the natural history of diseases in gastrointestinal tract

Usufulness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis

ERK is involved in the differentiation induced by diallyl disulfide in the human gastric cancer cell line MGC803

Professor Ludwik Rydygier father and legend of Polish surgery

Stomach wall changes caused by the presence of third-stage Anisakis simplex B larvae in infected dogs