Wyniki wyszukiwania

1

Lung function - clinical importance, problems, and new results

100%

Ulmer W. T.

Journal of Physiology and Pharmacology. Supplement

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2003

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tom 54

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nr 1

11-13

This review tackles the usefulness of spirometry, a more than century old method of assessing pulmonary lung function. Variables measured with a spirometer, such as forced expiratory volume in 1 s, have long been the mainstays of the diagnosis and treatment of lung disorders. But there are problems with the reliability of spirometric measurements. The method depends on the cooperation of the investigated subject, which introduces a confounding subjective element and all too often results in test failure, and the results are evaluated against the predicted values that are based on a set of fixed factors, some of which, such as body height, are not in a straight proportion to the intrathoracic gas volume. Substantial spread of results arises, which makes a reliable assessment of lung function difficult. New methods, such as the resistance-volume curve, provide better information on airway behavior in different conditions. These new methods, which basically evolved from spirometry, show that the old idea of lung function analysis is still viable and may remain helpful for diagnosis and treatment of respiratory pathological states.

2

The effect of breath-hold diving on selected adaptive mechanisms in the circulatory-respiratory system in simulated static and dynamic apnoea

100%

Solich-Talanda M., Mikolajczyk R., Roczniok R., Zebrowska A.

Baltic Journal of Health and Physical Activity. The Journal of Gdansk University of Physical Education and Sport

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2019

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tom 11

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nr 1

3

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Experiences of a Slovak PhD pioneer

86%

Bendova J.

Medical Science Pulse

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2018

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tom 12

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nr 1

It has all started 10 years ago, at my first WON CA Europe conference in Istanbul in 2008, where I became amazed by so many general practitioners, who performed and presented their scientific work there. However it took me 7 years since the idea to start my PhD studies until it´s final completion in 2017. My PhD journey wasn´t straight, but rather twisty, with 2 interruptions. In 2011 I started to earn my basic research skills at 2 courses. The first one was the European General Practice Research Network (EGPRN) course in Nice and the second University of Crete´s research workshop in Slovakia lead by Professor Christos Lionis. The easiest part of my PhD studies was the clinical one – administering questionnaire and performing spirometry with my patients at my rural general practice. I also enjoyed teaching medical students at undergraduate as well as postgraduate level. I gave lectures at national conferences and published articles about general medicine in Slovak scientific journals, focusing on prevention, patient safety and respiratory diseases, especially COPD. I also contributed to two medical text books. My research was presented as posters or oral presentations at 3 WONCA Europe conferences, where I found a great space for sharing research ideas and results. Final results of my PhD thesis are going to be presented at Krakow conference. Even though I was a fruitful author of publications, reaching the goal of an international publication was the most difficult part for me, not achievable without a help of experienced colleague, Austrian general practitioner, Professor Gustav Kamenski.

4

New insights into physiology and pathophysiology by resistance-volume recordings

86%

Ulmer W. T., Schafer T.

Journal of Physiology and Pharmacology. Supplement

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2004

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tom 55

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nr 3

149-153

This work deals with the assessment of airway resistance in the course of a single breath. The study showed the presence of an early increase in the resistance at the beginning of expiration, which intensifies during expiration and ends up with a sharp decline during expiring the last remaining volume of ca 350 ml. The dynamic changes in airway resistance over a breath depend on the disharmonic interplay between diaphragm function and bronchial wall tonus. Thus, airway resistance is not constant during breathing, as could be misleadingly judged from the total resistance averaged over a breath. The study underscores the importance of recording the resistance-volume curves alongside the standard flow-volume curves to be able to discern the peculiarities of airway resistance changes during a single breath. Knowing changes in the instantaneous airway resistance characteristic for a given lung pathology could appreciably improve the diagnostic and therapeutic powers.

5

Pulmonary function between 40 and 80 years of age

86%

Ostrowski S., Grzywa-Celinska A., Mieczkowska J., Rychlik M., Lachowska-Kotowska P., Lopatynski J.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 4

127-133

Spirometry is the most frequently performed lung function test. To determine a normal range of spirometry results, reference formulas are used. Predicted values play an important role in establishing whether the volumes measured in an individual fall within a range to be expected in a healthy person of the same gender, height, and age. Such standards enable to assess the development of the respiratory system in the youth, the early recognition of the influence of a disease on the respiratory system and the influence of environmental factors on lung function. The objective of the present study was to estimate lung function prediction equations and to identify appropriate normal reference values for the Lublin Region local population of adults. We addressed the issue by analyzing the data from a lung function screening program conducted in the Lublin Region of Poland. Pulmonary function of adults aged 40-80 years was assessed from the measurements of forced vital capacity (FVC) and forced expired volume in the first second (FEV1) in 136 adults. Reference values of FVC and FEV1 for females and males were calculated by linear multiple regressions with age and height used as predictors. Different equations were compared to show their reliability when applied to the local population. The results were as follows. In females, the mean FEV1 was 2.856 ±0.534 (L) (113.7 ±14.3%) and the mean FVC was 3.517 ±0.662 (L) (118.5 ±14.1%), in males, 3.913 ±0.773 (L) (110.9 ±15.1%), 4.922 ±0.941 (L) (112.1 ±14.1%), respectively. The estimated prediction equations were: for the FVC - for females - FVC (L) = 0.0528 (height) - 0.0262 (age) - 3.676 and for males - FVC = 0.0756 (height) - 0.0649 (age) - 4.904; and for the FEV1 - for females - FEV1 (L) = 0.0378 (height) - 0.0282 (age) - 1.799 and for males - FEV1 (L) = 0.0553 (height) - 0.0553 (age) - 2.874. Units are years for age and centimeters for height. In conclusion, the analysis of the lung function data showed that there were significant difficulties in determining the appropriate reference values of FEV1 and FVC. The predicted FEV1 and FVC values derived from equations based on the ECSC (1) reference populations are considerably lower than those calculated in the present study, re-emphasizing the need to be cautious when applying the ECSC reference values for the local Lublin population. There seems to be a need for a constant refinement of spirometric standards.

6

Seasonal variations in work-related health effects in swine farm workers

72%

Bonlokke J. H., Meriaux A., Duchaine C., Godbout S., Cormier Y.

Annals of Agricultural and Environmental Medicine

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2009

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tom 16

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nr 1

43-52

7

Pulmonary functional indices during exercise in healthy and asthmatic adults

72%

Ghanbarzadeh M.

Studies in Physical Culture and Tourism

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2010

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tom 17

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nr 1

8

Spirometric and ergospirometric evaluation of wheelchair rugby players

72%

Domaszewska K., Szymczak L., Krysciak J., Pospieszna B., Laurentowska M.

Trends in Sport Sciences

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2013

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tom 20

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nr 2

Introduction. Cervical spinal cord injury is one of most common human body deficiencies. Quadriplegia affects not only the mass of paralyzed muscles, but also disrupts physiological exercise adaptation mechanisms. One of the few sports suitable for individuals with cervical spine impairment is wheelchair rugby. Professional athletes display a higher exercise capacity than untrained people with a similar degree of spinal damage. The reduction of aerobic capacity in individuals with cervical spinal cord injury is multifactorial. In addition to cardio-pulmonary mechanisms limiting the exercise capacity, the decrease in active muscle mass leads to the rapid development of tissue hypoxia. Material and Methods. 14 members of the Polish National Wheelchair Rugby Team were recruited for the study. The male players aged 20-40 years with cervical spinal cord injuries underwent spirometric and ergospirometric tests. Results. The mean values of spirometric parameters were: VC 3.9 ± 0.71 l (71.3% predicted), ERV 0.9 ± 0.33 l (60.7% predicted), VE 12.6 ± 6.34 4 l/min, Bf 18.3 ± 4.72 l/min, VT 0.7 ± 0.20 l, FVC 4.05 ± 0.69 l/min (76.3% predicted), FEV₁,₀/FVC 92.2 ± 7.10% (113.45% predicted), MVV 141.7 ± 24.59 l/min (97.15% predicted). The mean value of peak oxygen consumption during exercise was 1.31 ± 0.30 l/min (17.8 ± 4.99 ml/kg/min) achieved within 11.8 ± 3.51 min. The mean maximal workload was 42.5 ± 13.99 W. During the test only 10 players reached the anaerobic threshold (AT) intensity. The mean workload at AT was 36 ± 10.62 W, and VO2 max at AT was 0.9 ± 0.26 l/min (15.5 ± 4.17 ml/kg/min). Conclusions. The results of spirometric tests indicate the presence of mild and medium restrictive pulmonary changes in 8 out of the studied players of the Polish National Wheelchair Rugby Team. The physiological parameters obtained during the exercise test indicate a higher aerobic capacity of surveyed athletes in comparison with untrained quadriplegics.

9

Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold

72%

Plevkova J., Varechova S., Brozmanova M., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

289-296

Cough associated with upper respiratory tract disorders is a common and troublesome problem in children and little is known about the etiology of this type of cough. This study examined the capsaicin cough sensitivity (CS) in children suffering from allergic rhinitis (AR) and upper respiratory tract infection (URI), comparing it with that in healthy children taken as controls (C). CS to capsaicin, spirometry, skin prick tests, and nose-throat examination were performed in 61 children grouped by the diagnosis of AR, URI, and C. The results, in order of C vs. AR vs. URI, expressed as a geometric mean (±95% CI) log10 µM of capsaicin for C2 (the lowest concentration of capsaicin in µmol/l required to induce 2 coughs) were: 1.8 (1.6-1.9) vs. 1.0 (0.8-1.2) vs. 0.48 (0.2-0.8), P<0.001 and for C5 (the lowest concentration of capsaicin in µmol/l required to induce 5 coughs) 2.9 (2.8-2.9) vs. 2.6 (2.5-2.6) vs. 2.1 (2.0 –2.3), P<0.05. We found that CS in children with AR, even when tested out of pollen season, was significantly heightened compared with controls. CS in children with URI was extremely high compared with both C and AR groups. We conclude that pathological processes in the nose of any etiology could cause a sensitization of the cough reflex with decreased cough threshold during asymptomatic period of AR. Cough also is enhanced by acute inflammation in the upper airways in nonatopic children.

10

How accurate is spirometry at predicting restrictive pulmonary impairment in children with myasthenia gravis

72%

Zielonka T., Kostera-Pruszczyk A., Ryniewicz B., Korczynski P., Szyluk B.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

409-416

Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction. Clinical symptoms are caused by weakness and increased fatigability of various muscle groups. Myasthenia may lead to significant respiratory dysfunction. The aim of our study was to estimate lung function in children with MG. We tested 23 non-smoking patients (18 girls and 5 boys) aged 7-18 years. Whole-body plethysmography and spirometry were performed in all patients. In 33% of the patients a decrease in VC <80% of predicted value was observed (VC = 89 ±19%), but the analysis of TLC revealed restrictive pattern only in one patient (TLC = 102 ±17%). In more than 75% of the children the value of RV above 120% of predicted value was found (RV = 146 ±54%). Spirometric obstructive pattern measured by FEV1%VC <70% was not observed, although in 56% of the patients airway resistance was increased (Raw = 132 ±44%). In 45% of the patients a decrease of PEF (76 ±14%) was observed. In MG children true restrictive pulmonary impairment is rarely observed and a decrease in VC in these patents seems to result mainly from functional restriction provoked by an increase in RV. Spirometry is not an optimum method to assess functional changes in MG patients. The assessment of additional measures such as TLC, RV, and Raw is desirable.

11

Tussigenic agents in the measurement of cough reflex sensitivity

72%

Pecova R., Javorkova N., Kudlicka J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

12

Spirometry in preschool children: time has come for new reference values

72%

Kalhoff H., Breidenbach R., Smith H. J., Marek W.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 5

13

Spirometric parameters in malnourished girls with anorexia nervosa

72%

Ziora K., Ziora D., Oswiecimska J., Roczniak W., Machura E., Dworniczak S., Tomalak W., Dyduch A.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

801-807

14

Spirometric values and aerobic efficiency of children and adolescents with hearing loss

72%

Zebrowska A., Zwierzchowska A.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

443-447

Vital capacity (VC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), mean forced expiratory flow (FEV25-75), and maximum voluntary volume (MVV) were measured in 36 girls and 36 boys with hearing loss and compared with the same number of normal healthy children, all subjects were aged 10-16 years. They participated in an exercise test to calculate VO2 max in order to determine their physical efficiency. We found that all spirometric indices tended to be lower in deaf children, in all age-groups studied and irrespective of gender, compared with their hearing counterparts; the differences assumed significance with respect to PEF and MVV (P<0.05). Moreover, some deaf children had an appreciably lower level of VO2max compared with hearing children. Our results demonstrate that sensory deprivation of deaf children affects functional capabilities of the respiratory system.

15

Factors influencing lung function: are the predicted values for spirometry reliable enough?

72%

Ostrowski S., Barud W.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

263-271

Spirometric lung function parameters are used as a diagnostic tool and to monitor therapy effectiveness or the course of disease. On the other hand, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) are important predictors of morbidity and mortality in elderly persons. In clinical use, FEV1 and FVC are measured in liters and usually each is expressed as a percentage of the predicted value. Reference values used for the prediction of lung function should be reliable. It seems crucial that the reference cohort be representative. There is no doubt that gender and height are the most important predictors of lung function. The third predictor, age, may be a confounding factor. The study of age-dependent changes in lung function through the lifespan reveals distinctive differences. The FEV1 and FVC in adults are related to the maximum level attained, the plateau period, and the rate of lung function decline. A non-linear dependence between age and lung function parameters is more complex. The maximum level of lung function, possible to attain, is influenced by a genetic factor. The plateau and decline phases are closely connected with several independent predictors. In the last decade, some new factors influencing lung function have been established. A relation between lung function and hyperglycemia of diabetes mellitus is a novel field of interest. Also, the influence on lung function of waist size, weight, and body composition or muscle strength are underscored. These, previously not full well unrecognized, factors make it difficult to get accurate norms with regression equations, traditionally using sex, height, and age as predictors.

16

Impact of training with additional respiratory dead space on spirometry and exercise respiratory pattern in cyclists

72%

Hebisz R. G., Hebisz P., Zaton M. W.

Central European Journal of Sport Sciences and Medicine

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2015

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tom 09

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nr 1

The aim of our 10-week-long experiment was to investigate the impact of training with additional dead space (DS) on spirometry and exercise respiration. Respiratory muscle training is applied to the development exercise capacity. Twenty cyclists were assigned to two groups: the experimental (E) and the control (C). All of them carried on with their initial training programme. During endurance trainings (twice per week) group E used additional DS (1000 cm3). Immediatelly before and after the experiment each participant was submitted to a spirometry and a continuous test. The spirometry test measured peak inspiratory (PIF) and expiratory (PEF) flows, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). The continuous test measured tidal volume (TV), respiratory frequency (RF), along with inspiration and expiration times. Our experiment demonstrated TV increase and RF decrease in both groups. In addition, the TV value was significantly higher in group E than in C. The PIF value also increased significantly, PEF and FEV1 upward trend was observed in group E only. We concluded the additional respiratory DS used in the experimental group provoked an increase of airflow observed in the spirometry tests at rest and during intensive aerobic exercise.

17

Left ventricular dysfunction in patients with interstitial lung diseases referred for lung transplantation

72%

Jastrzebski D., Nowak J., Ziora D., Wojarski J., Czyzewski D., Kozielski J., Polonski L., Zembala M.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

18

Asthma management at primary care level: symptoms and treatment of 3305 patients with asthma diagnosed by a family physician

58%

Doboszynska A., Swietlik E.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

231-241

19

Role of gender and pubertal stage on cough sensitivity in childhood and adolescence

58%

Varechova S., Plevkova J., Hanacek J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

719-726

20

Relationship between airway wall thickness assessed by high-resolution computed tomography and lung function in patients with asthma and chronic obstructive pulmonary disease

58%

Kosciuch J., Krenke R., Gorska K., Zukowska M., Maskey-Warzechowska M., Chazan R.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 5

Ograniczanie wyników

Lung function - clinical importance, problems, and new results

The effect of breath-hold diving on selected adaptive mechanisms in the circulatory-respiratory system in simulated static and dynamic apnoea

Experiences of a Slovak PhD pioneer

New insights into physiology and pathophysiology by resistance-volume recordings

Pulmonary function between 40 and 80 years of age

Seasonal variations in work-related health effects in swine farm workers

Pulmonary functional indices during exercise in healthy and asthmatic adults

Spirometric and ergospirometric evaluation of wheelchair rugby players

Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold

How accurate is spirometry at predicting restrictive pulmonary impairment in children with myasthenia gravis

Tussigenic agents in the measurement of cough reflex sensitivity

Spirometry in preschool children: time has come for new reference values

Spirometric parameters in malnourished girls with anorexia nervosa

Spirometric values and aerobic efficiency of children and adolescents with hearing loss

Factors influencing lung function: are the predicted values for spirometry reliable enough?

Impact of training with additional respiratory dead space on spirometry and exercise respiratory pattern in cyclists

Left ventricular dysfunction in patients with interstitial lung diseases referred for lung transplantation

Asthma management at primary care level: symptoms and treatment of 3305 patients with asthma diagnosed by a family physician

Role of gender and pubertal stage on cough sensitivity in childhood and adolescence

Relationship between airway wall thickness assessed by high-resolution computed tomography and lung function in patients with asthma and chronic obstructive pulmonary disease