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1

Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells

100%
Wojcik M., Baranska J.
Acta Biochimica Polonica
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1999
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tom 46
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nr 1
The effect of sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate on L-[U-14C]serine incorporation into phosphatidylserine and phosphatidylserine-derived phosphatidylethanolamine was investigated in intact glioma C6 cells. Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate are potent signalling molecules which, due to their physicochemical features, may function as amphiphilic compounds. It has been found that sphingosine and sphingosylphosphorylcholine (amphiphilic cations) significantly increase [14C]phosphatidylserine synthesis and decrease the amount of 14C-labeled phosphatidylethanolamine. Sphingosine 1-phosphate (an amphiphilic anion) was without effect on phosphatidylserine synthesis but, similarly as sphingosine and sphingosylphosphorylcholine, reduced the conversion of phosphatidylserine to phosphatidylethanolamine. These results strongly suggest that sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate can modulate cellular phospholipid homeostasis by stimulation of phosphatidylserine synthesis and an interference with phosphatidylserine decarboxylase.
2
Content available remote

Effect of atrial pacing on the level of bioactive sphingolipids in the heart ventricles of the rat

84%
Wojcik B., Baranowski M., Chabowski A., Gorski J.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 3
3

Sphingosine modulates Ca2 signals via phospholipase C dependent pathway in glioma C6 cells

84%
Czajkowski R., Sabala P., Baranska J.
Acta Neurobiologiae Experimentalis
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1997
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tom 57
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nr 4
4
Content available remote

Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat

84%
Dobrzyn A., Zendzian-Piotrowska M., Gorski J.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 2
The sphingomyelin signalling pathway has been shown to function in different skeletal muscle types. The aim of the present study was to examine the effect of endurance training on the functioning of the pathway in the muscles. The experiments were carried out on two groups of male Wistar rats: sedentary and trained for six weeks. 24h after cessation of the training rats were anaesthetized and samples of the soleus, red and white section of the gastrocnemius were taken. The content and composition of sphingomyelin-fatty acids and ceramide - fatty acids was determined by means of gas-liquid chromatography. The content of sphingosine and sphinganine was determined by means of high-pressure liquid chromatography. The activity of neutral Mg++-dependent sphingomyelinase was determined spectophotometrically using trinitrophenylaminolauroyl-sphingomyelin as the substrate. It has been found that training reduces the total content of sphingomyelin- and ceramide-fatty acids, increases the content of sphinganine and does not affect the content of sphingosine in individual muscle types. The activity of the enzyme in the muscles is also elevated. It is concluded that training affects functioning of the sphingomyelin -signalling pathway in skeletal muscles. The reduction in the content of ceramide may contribute to elevation in glucose uptake in skeletal muscles observed after training.
5
Content available remote

Cardioprotective role of sphingosine-1-phosphate

67%
Knapp M.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 6
6

Sphingosine stimulates calcium mobilization and modulates calcium signals evoked by thapsigargin in glioma C6 cells

67%
Sabala P., Wiktorek M., Czarny M., Chaban V., Baranska J.
Acta Neurobiologiae Experimentalis
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1996
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tom 56
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nr 2
7

On the character and functions of sphingolipids

67%
Karlsson K. A.
Acta Biochimica Polonica
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1998
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tom 45
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nr 2
Sphingolipids form a large group of membrane lipids showing a diversity of molecular species. Specific functions associated with the saccharide part of glycosphingolipids including co-receptor functions, cell homing phenomena, and attachment by microbes and microbial toxins may not be unique for sphingolipids. However, there are saccharides which appear only in ceramide-bound form and not in other glycoconjugates, and such glycolipids have often been selected as attachment sites by microbes. During the last few years convincing evidence has been presented in favor of ceramide and sphingosine being signaling molecules for various cell functions. The influence of sphingolipids (ceramide) on the properties of the membrane bilayer is still largely unknown. However, based on the structure of ceramide and some experimental evidence one may formulate its role in membrane stability and barrier properties determined by hydrogen bonding in the amide region of ceramide. Furthermore, a natural variation in the number of hydroxyl groups (of fatty acid and long-chain base) may be important for regulation of the potential hydrogen bonds.
8

Immunochemical characterization of lipopolysaccharide from glucose-nonfermenting Gram-negative clinical bacterial isolate

67%
Mieszala M., Kubler J., Gamian A.
Acta Biochimica Polonica
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1997
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tom 44
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nr 2
A glucose-nonfermenting Gram-negative bacterial strain isolated from bronchofiberoscope used for examination of the patients suffering from pulmonary diseases was subjected to phenol-water extraction. Lipopolysaccharides (LPS) isolated from the water and the phenol phase differed in fatty acid composition. Both contained xylose, glucose, glucosamine and components typical for LPS, namely heptose, 3-deoxyoctulosonic acid (Kdo) and 3-hydroxymyristic acid. The presence of sphingosine in all LPS preparations classifies the strain to the genus Sphingomonas.
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