The present study is aimed at the determination of the character and intensity of morphological lesions in the skin, subjected to action of sodium lauryl sulphate as well as establishing, and if yes, to which extent the dermal process induced by primary chronic irritant, affects the reaction to secondary application of the damaging agent. The experiments were conducted on 24 white male mice of the inbred Balb/c strain. Surface of hairy skin (approximately 1 cm²), in the lumbo-dorsal region, was subjected to the action of sodium lauryl sulphate. The studies demonstrated differences in the intensity of the reaction not only among individual groups of experimental animals or individual animals within the group, but also between neighbouring sites in the skin of the same individual. Both the extent of thickening of epidermis and intensity of its keratinisation differed significantly between individual fields of the same section. In vicinity of necrotic regions, the areas were noted in which the epidermis underwent slight hypertrophy only or was almost unaltered, comparable to the control.
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