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Role of nesfatin-1 in the metabolism of skeletal tissues

100%

Puzio I., Tymicki G., Predka H., Sleboda W., Sobczynska-Wolejszo M.

Medycyna Weterynaryjna

2018

tom 74

nr 05

NUCB2/nesfatin-1, a member of the adipokine family, is a peptide hormone with pleiotropic action. It has been found in different tissues, including cartilage and bone cells. Nesfatin-1 is produced by chondrocytes, and its synthesis increases with the degree of cell differentiation and upon stimulation by pro-inflammatory cytokines, as shown in an in vitro study. An increase in serum levels of nesfatin-1 has been observed in humans with osteoarthritis, which indicates the influence of pro-inflammatory cytokines on nesfatin-1 release. On the other hand, nesfatin-1 stimulates the synthesis of pro-inflammatory cytokines by chondrocytes, which suggests its participation, together with other adipokines, in the pathogenesis and/or progression of inflammatory complications of cartilage degenerative diseases. Nesfatin-1 also promotes pre-osteoblastic cell differentiation and mineralization and inhibits macrophage differentiation towards osteoclasts. Moreover, exogenous nesfatin-1 given to ovariectomized rats reduces osteopenic changes. Therefore, it seems that nesfatin-1 may play a protective role in cartilage and bone diseases. However, further studies are required to determine whether nesfatin-1 can be used for monitoring and treatment of cartilage and bone diseases.

Mechanical and chemical alterations of skeletal tissues in a recent Saharian accumulation of faeces from Vulpes rueppelli [Carnivora, Mammalia]

100%

Denys C., Kowalski K., Dauphin Y.

Acta Zoologica Cracoviensia

1992-1993

tom 35

nr 2

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The ultrastructure and building of graptolite dissepiments

80%

Urbanek A., Mierzejewski P.

Acta Palaeontologica Polonica

2009

tom 54

nr 2

243-252

Dissepiments or connecting bars between adjacent stipes in rhabdosomes of dendroid graptolites were studied by means of electron microscopy (SEM and TEM). The material, chemically isolated from rock matrix, originating from the Ordovician of Estonia and glacial boulders of Baltic origin found in Poland, is assigned provisionally to the genus “Dictyonema” sensu lato. Early growth stages of dissepiments are made only of the fusellar component. Older dissepiments are composed of the central core and the outer envelope: the central core is made of rather irregularly arranged growth units made of the fusellar tissue, whereas the outer envelope has a distinct cortical appearance. TEM observations indicate that the fusellar component is made of both typical fusellar and microfusellar tissues (the latter with complete and reduced microfuselli). The cortical component of dissepiments is made both of dependent and independent cortex. The opinion is advanced that the dissepiments were constructed externally by the mortaring activities of zooids, similar to that of Recent Cephalodiscus. Our observations indicate that bizooids were most probable dissepiment constructors. These results, in general, does not support earlier opinions that dissepiments are made of cortical tissue acquiring a fusellar aspect in some cases, and that dissepiments were produced by the extrathecal membrane surrounding the rhabdosome.

Ograniczanie wyników

1 Acta Palaeontologica Polonica

1 Acta Zoologica Cracoviensia

1 Medycyna Weterynaryjna

1 Dauphin Y.

1 Denys C.

1 Kowalski K.

1 Mierzejewski P.

1 Predka H.

1 Puzio I.

1 Sleboda W.

1 Sobczynska-Wolejszo M.

1 Tymicki G.

1 Urbanek A.

1 2018

1 2009

1 1993

Wyniki wyszukiwania

Role of nesfatin-1 in the metabolism of skeletal tissues

Mechanical and chemical alterations of skeletal tissues in a recent Saharian accumulation of faeces from Vulpes rueppelli [Carnivora, Mammalia]

The ultrastructure and building of graptolite dissepiments