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1

Sister chromatid exchange in Polish White Improved goats (Capra hircus)

100%
Wojcik E., Smalec E.
Folia Biologica
|
2012
|
tom 60
|
nr 3-4
2

Estiamtion of BrdUrd-independent sister chromatid exchanges and proliferation rate of human lymphocytes in vitro

100%
Kotecki M., Pawlak A. L.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1989
|
tom 37
|
nr 10-12
3

Crossbreeding effect on genome stability in pig (Sus scrofa scrofa)

84%
Ciotola F., Albarella S., Scopino G., Carpino S., Monaco F., Peretti V.
Folia Biologica
|
2014
|
tom 62
|
nr 1
4

Boric acid as a protector against paclitaxel genotoxicity

84%
Turkez H., Tatar A., Hacimuftuoglu A., Ozdemir E.
Acta Biochimica Polonica
|
2010
|
tom 57
|
nr 1
95-97
 Paclitaxel (PAC) is an anticancer drug used for treatments of breast, ovarian and lung cancers. However, little data is; available in the literature on its potential genotoxicity on healthy human cells. On the other hand, boron deficiency and supplementation exert important biological effects in human and animal tissues. The biological effects of dietary boron are defined, but its interaction with PAC is not known for therapeutic uses. The aim of the present study was to determine whether boric acid (BA) confer a protection against PAC genotoxicity. After the application of PAC (10 or 20 μg/l) and BA (2.5 or 5 mg/l), the genotoxic effects were assessed by sister chromatid exchange (SCE) and micronucleus (MN) tests in human blood cultures. We also analyzed nuclear division index (NDI) in peripheral lymphocytes. Our results showed that PAC significantly (P < 0.05) increased the frequencies of SCEs and the formations of MNs in peripheral lymphocytes as compared to controls. PAC decreased the nuclear division index in lymphocyte cultures. Boric acid did not show cytotoxic or genotoxic effects at the concentrations tested. Furthermore, the PAC-induced increases in the genotoxicity and cytotoxicity indices were diminished by the addition of BA. The present study suggests for the first time that BA can prevent the genotoxicity of PAC on human lymphocytes.
5

Evaluation of BrdU influence on sister chromatin exchange in Arctic and silver fox

84%
Grzesiakowska A., Klott A., Kuchta-Gladysz M., Niedbala P., Otwinowska-Mindur A., Szeleszczuk O.
Folia Biologica
|
2017
|
tom 65
|
nr 2
6

The effect of environmental factors on sister chromatid exchange incidence in domestic horse (Equus caballus) chromosomes

84%
Wojcik E., Smalec E.
Folia Biologica
|
2013
|
tom 61
|
nr 3-4
7
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Effects of acetylsalicylic acid and a new pyrazine derivative PD-101 on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes

84%
Wozniak A., Limon J., Petrusewicz J., Kaliszan R.
Journal of Applied Genetics
|
1998
|
tom 39
|
nr 3
Acetylsalicylic acid (ASA) and α-2-pyrazylidene-α-cyano N-butyl acetamide (PD-101), a new antiaggregatory pyrazine derivative were tested for their genotoxicity in human lymphocytes in vitro using the sister chromatid exchange (SCE) technique. Both compounds were found to be inactive in inducing SCE in concentration from 1 µM up to 1000 µM. The agents displayed inhibitory effect on cell kinetics.
8
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Influence of diethylenetriamine [DETA] and sodium nitroprusside [NaNP] on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes

84%
Perkowska M., Szczygiel M., Wozniak A., Limon J.
Journal of Applied Genetics
|
2001
|
tom 42
|
nr 2
9

Chromosome aberrations, sister chromatid exchanges [SCE] and cell division kinetics in human lymphocytes exposed in vitro to purified trypsin inhibitor from Ascaris

67%
Blaszkowska J., Bratkowska A., Lopaczynska D., Strozynski H., Ferenc T.
Journal of Applied Genetics
|
2004
|
tom 45
|
nr 2
10
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Analysis of chromosome aberrations, sister chromatid exchanges [SCE] and cell division kinetics in human lymphocytes exposed in vitro to new monophosphates of pyrimidine acyclonucleosides

67%
Ferenc T., Rutkowski M., Bratkowska W., Hubner H., Draminski M.
Journal of Applied Genetics
|
1998
|
tom 39
|
nr 1
Five newly synthesised monophosphates of two pyrimidine acyclonucleoside series, namely 1-N-[(2’-hydroxy)ethoxymethyl] and l-N-[(l’,3’-dihydroxy)- 2’-propoxymethyl] derivatives of 5- and 5,6-alkylated uracils were tested in vitro for chromosome aberrations and sister chromatid exchanges (SCE). Metaphase plates were obtained via microculture of human lymphocytes from heparinized peripheral blood. The compounds were tested in doses: 10, 20, 40, 80 and 150 µg per mL of culture. The tested compounds induced mainly chromatid gaps, less frequently chromosome gaps. A low number of mitoses with chromatid and chromosome breaks, acentric fragments, dicentric chromosomes and exchange figures were also observed. The tested compounds in doses: 40, 80 and 150 µg per mL, doubled or tripled the percentage of cells with chromatid gaps and chromosome gaps as compared to the control. The percentage o cells with aberrations (excluding gaps) induced by the tested compounds in all doses did not exceed 2%. The tested compounds induced a higher number of SCE per cell but less than double frequency as compared to the control. SCE frequencies and replication index (RI) values varied depending on the examined compounds. For the highest dose of the tested compounds (150 µg per mL) a significant decrease in RI values was observed for l-N-[(2’-hydroxy)ethoxymethyl]-5,6-tetramethyleneuracil monophosphate and for l-N-[(2’-hydroxy)ethoxymethyl]-5,6-dimethyluracil monophosphate. So far, the results have indicated potential clastogenicity of all the tested compounds except acycloguanosine monophosphate.
11

Phenotypic transformation of hamster kidney cells by extracts of airborne pollutants from Upper Silesia

59%
Motykiewicz G., Szeliga J., Seemayer N. H.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1995
|
tom 43
|
nr 2
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