Wyniki wyszukiwania

1

Pravastatin and simvastatin pretreatment in combination with pyrimethamine and sulfadiazine reduces infection process of Toxoplasma gondii tachyzoites (RH strain) in HeLa cells

100%

da Silva Sanfelice R. A., da Silva S. S., Bosqui L. R., Machado L. F., Miranda-Sapla M. M., Panagio L. A., Navarro I. T., Conchon-Costa I., Pavanelli W. R., Almeida R. S., Costa I. N.

Acta Parasitologica

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2019

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tom 64

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nr 3

2

Ageing influences the effect of pre-hypoxic administration of clonidine, an alpha2-adrenoceptor agonist, on post-hypoxic vasomotoricity

84%

Gourdin M. J., Ponchau O., Jamart J., De Kock M.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 2

3

Inhibition of Barrett's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins

84%

Konturek P. C., Burnat G., Hahn E. G.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 3

141-148

4

Anti-inflammatory effects of simvastatin in nonsteroidal anti-inflammatory drugs-induced small bowel injury

84%

Kim E. K., Cho J. H., Jeong A. R., Kim E. J., Park D. K., Kwon K. A., Chung J. W., Kim K. O., Kim J. H., Kim J. H., Kim Y. J.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 1

5

Effect of 3 months' simvastatin treatment on levels of copper and zinc in serum of patients with coronary heart disease

84%

Piorunska-Mikolajczak A., Piorunska-Stolzmann M., Baralkiewicz D., Mikolajczyk Z.

Journal of Elementology

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2005

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tom 10

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nr 4 Suppl.1

82-83

6

IL-6 and IL-8 responses of colorectal cancer in vivo and in vitro cancer cells subjected to simvastatin

67%

Malicki S., Winiarski M., Matlok M., Kostarczyk W., Guzdek A., Konturek P. C.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 4

141-146

Recent investigations suggest that proinflammatory cytokines such as IL-6 and IL-8 are involved in the development of colorectal cancer (CRC), whereas statins, primarily used to decrease high levels of blood cholesterol, exhibit pleiotropic effects on carcinogenesis. In the present study we compared the expression of IL-8 and IL-6 in tissue samples of tumor and adjacent normal colon mucosa obtained from patients with advanced colorectal cancer (CRC). The analysis of mRNAs expression for these proinflammatory cytokines determined by RT-PCR showed a higher level of IL-8-mRNA in tumor tissue than in normal mucosa, while IL-6 was similarly expressed in tumor and normal tissue. The mean values of serum levels of both IL-6 and IL-8 were significantly higher in CRC patients than in healthy volunteers. Surgical removal of the tumor resulted in a prompt decrease of serum level of IL-8 already on the third day, whereas IL-6 level was transiently increased to become lower only after 7-10 days. Treatment of CRC with simvastatin (80 mg/day for 14 days) led to a significant decrease of serum IL-6, while the IL-8 level was less affected. The in vitro experiments on colorectal cancer-derived cell lines (HT-29 and Caco-2) demonstrated that application of simvastatin decreased generation of both IL-6 and IL-8. The differences in response of serum levels of IL-6 and IL-8 after tumor removal and treatment with simvastatin are novel observations suggesting distinct pathological roles of the two cytokines in CRC development. We conclude that 1) colorectal carcinogenesis is accompanied by increased synthesis and release of proinflammatory cytokines such as IL-6 and IL-8; 2) simvastatin therapy results in a decrease in serum level of proinflammatory cytokines, especially IL-6 in CRC and 3) simvastatin inhibits release of IL-8 and IL-6 from colorectal cell lines.

7

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Influence of some statins on bacteria and actinomyces

67%

Targonski R., Kucharski J., Wyszkowska J.

Journal of Elementology

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2006

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tom 11

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nr 4

In an in uitro experiment the effect of three statins (atorvastatin [Sortis], simvastatin [Zocor], fluvastatin [Lescol]) on the growth of 5 bacterial strains Bacillus subtilis, Bacillus cereus, Proteus vulgaris, Pseudomonas fluorescens, Escherichia coli and 4 saprophytic actinomycetes Streptomyces longisporoflavus, Streptomyces intermedius, Streptomyces odoriver, Streptomyces viridis was tested. The experiments were carried out on solidified substrata with microorganisms covered with filter paper rings soaked with aqueous solution of every tested statin used in different concentrations. It was found that examined substances can inhibit the growth of certain saprophytic microorganisms. Fluvastatin rather than simvastatin or atorvastatin produces stronger effect on bacteria and actinomycetes.

8

Alteration in expressions of RhoA and Rho-kinases during pregnancy in rats: their roles in uterine contractions and onset of labour

67%

Domokos D., Ducza E., Falkay G., Gaspar R.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 3

9

Different effects of simvastatin on ex vivo monocyte cytokine release in patients with hypercholesterolemia and impaired glucose tolerance

67%

Krysiak R., Okopien B.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 6

10

Statyny i ich interakcje z pozywieniem. Cz.II. Symwastatyna, fluwastatyna, atorwastatyna, rozuwastatyna

51%

Piotrowicz J., Pazur A., Zachwieja Z.

Bromatologia i Chemia Toksykologiczna

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2008

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tom 41

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nr 4

1023-1029

Ograniczanie wyników

Pravastatin and simvastatin pretreatment in combination with pyrimethamine and sulfadiazine reduces infection process of Toxoplasma gondii tachyzoites (RH strain) in HeLa cells

Ageing influences the effect of pre-hypoxic administration of clonidine, an alpha2-adrenoceptor agonist, on post-hypoxic vasomotoricity

Inhibition of Barrett's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins

Anti-inflammatory effects of simvastatin in nonsteroidal anti-inflammatory drugs-induced small bowel injury

Effect of 3 months' simvastatin treatment on levels of copper and zinc in serum of patients with coronary heart disease

IL-6 and IL-8 responses of colorectal cancer in vivo and in vitro cancer cells subjected to simvastatin

Influence of some statins on bacteria and actinomyces

Alteration in expressions of RhoA and Rho-kinases during pregnancy in rats: their roles in uterine contractions and onset of labour

Different effects of simvastatin on ex vivo monocyte cytokine release in patients with hypercholesterolemia and impaired glucose tolerance

Statyny i ich interakcje z pozywieniem. Cz.II. Symwastatyna, fluwastatyna, atorwastatyna, rozuwastatyna