Wyniki wyszukiwania

1

The role of the NUR77 family of nuclear receptors in the signalling pathways of thymocytes and neurons

100%

Matuszyk J.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

2

Signalling protein inhibitors via the combinatorial modification of peptide scaffolds

88%

Lawrence D. S.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

3

Signalling pathways regulating transcription, mRNA stabilisation and intracellular transport of cytokines in activated mast cells

88%

Dastych J., Walczak-Drzewiecka A., Adamczewska V., Trzaska D., Olszewski M., Wyczolkowska J.

Cellular and Molecular Biology Letters

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2002

|

tom 07

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nr Suppl.

4

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Signalling and multiple regulatory mechanisms for NADPH oxidase-mediated deliberate ROS production in plant cells

75%

Kuchitsu K., Kitahata N., Kimura S., Kawarazaki T., Kaya H., Kurusu T.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 2

5

The cysteine-rich receptor-like kinase family in Arabidopsis – a phenotypic framework for stress responses and ROS signaling

75%

Bourdais G., Burdiak P., Gauthier A., Nitsch L., Rayapuram C., Salojarvi J., Tri Anggoro D., Glow D., Zhou J., Kaufholdt D., Oracz K., Idanheimo N., Willem Borst J., Collinge D. B., Karpinski S., L yngkjaer M. F., Robatzek S., Kangasjarvi J., Wrzaczek M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 2

6

Priming through H2O2-mediated signalling in Arabidopsis thaliana

75%

Balazadeh S., Shahnejat-Bushehri S., Muller-Rober B.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 2

7

Endocannabinoid signalling: a common target for high fat diets and substances of abuse?

75%

Di Marzo V.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 5

8

Qa-SNARE protein SYP22 negatively regulates brassinosteroid signaling in the dark

75%

Yao T. S., Zhu X. F., Jung J. H., Xuan Y. H.

Acta Biologica Cracoviensia. Series Botanica

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2015

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tom 57

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nr 2

9

Regulator of G-protein signalling expression and function in ovarian cancer cell lines

75%

Hurst J. H., Mendpara N., Hooks S. B.

Cellular and Molecular Biology Letters

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2009

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tom 14

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nr 1

153-174

Regulator of G-protein signalling (RGS)2 proteins critically regulate signalling cascades initiated by G-protein coupled receptors (GPCRs) by accelerating the deactivation of heterotrimeric G-proteins. Lysophosphatidic acid (LPA) is the predominant growth factor that drives the progression of ovarian cancer by activating specific GPCRs and G-proteins expressed in ovarian cancer cells. We have recently reported that RGS proteins endogenously expressed in SKOV-3 ovarian cancer cells dramatically attenuate LPA stimulated cell signalling. The goal of this study was twofold: first, to identify candidate RGS proteins expressed in SKOV-3 cells that may account for the reported negative regulation of G-protein signalling, and second, to determine if these RGS protein transcripts are differentially expressed among commonly utilized ovarian cancer cell lines and non-cancerous ovarian cell lines. Reverse transcriptase-PCR was performed to determine transcript expression of 22 major RGS subtypes in RNA isolated from SKOV-3, OVCAR-3 and Caov-3 ovarian cancer cell lines and non-cancerous immortalized ovarian surface epithelial (IOSE) cells. Fifteen RGS transcripts were detected in SKOV-3 cell lines. To compare the relative expression levels in these cell lines, quantitative real time RT-PCR was performed on select transcripts. RGS19/GAIP was expressed at similar levels in all four cell lines, while RGS2 transcript was detected at levels slightly lower in ovarian cancer cells as compared to IOSE cells. RGS4 and RGS6 transcripts were expressed at dramatically different levels in ovarian cancer cell lines as compared to IOSE cells. RGS4 transcript was detected in IOSE at levels several thousand fold higher than its expression level in ovarian cancer cells lines, while RGS6 transcript was expressed fivefold higher in SKOV-3 cells as compared to IOSE cells, and over a thousand fold higher in OVCAR-3 and Caov-3 cells as compared to IOSE cells. Functional studies of RGS 2, 6, and 19/GAIP were performed by measuring their effects on LPA stimulated production of inositol phosphates. In COS-7 cells expressing individual exogenous LPA receptors, RGS2 and RSG19/GAIP attenuated signalling initiated by LPA1, LPA2, or LPA3, while RGS6 only inhibited signalling initiated by LPA2 receptors. In SKOV-3 ovarian cancer cells, RGS2 but not RGS6 or RGS19/GAIP, inhibited LPA stimulated inositol phosphate production. In contrast, in CAOV-3 cells RGS19/GAIP strongly attenuated LPA signalling. Thus, multiple RGS proteins are expressed at significantly different levels in cells derived from cancerous and normal ovarian cells and at least two candidate RGS transcripts have been identified to account for the reported regulation of LPA signalling pathways in ovarian cancer cells.

10

The involvement of PPAR-alpha and PPAR-gamma signalling in long-term changes in lipogenic enzyme gene expression, as observed in rat adipose tissue after food restriction

75%

Kochan Z., Karbowska J.

Cellular and Molecular Biology Letters

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2002

|

tom 07

|

nr Suppl.

11

Protein kinase signalling cascade during nitric oxide-induced apoptosis, dedifferentiation and inflammatory responses of articular chondrocytes

75%

Chun J. S.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 2A

12

The immunological synapse

75%

Klemmensen T., Pedersen L. O., Geisler C.

Archivum Immunologiae et Therapiae Experimentalis

|

2003

|

tom 51

|

nr 6

13

Ligand-independent activity of the B cell antigen receptor in physiology and pathology

75%

Corcos D.

Archivum Immunologiae et Therapiae Experimentalis

|

2007

|

tom 55

|

nr 2

14

Molecular dissection of fertilisation signalling with the aid of tyrosine-kinase-specific inhibitors

75%

Sato K. I., Iwasaki T., Fukami Y.

Cellular and Molecular Biology Letters

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2003

|

tom 08

|

nr 2A

15

The decrease in PPAR-alpha signalling in the failing human heart - a possible explanation for energy substrate preference switch

75%

Karbowska J., Kochan Z., Smolenski R. T.

Cellular and Molecular Biology Letters

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2002

|

tom 07

|

nr Suppl.

16

Molecule dependent chemotactic responses of Tetrahymena pyriformis elicited by volatile oils

75%

Kohidai L., Lemberkovics E., Csaba G.

Acta Protozoologica

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1995

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tom 34

|

nr 3

17

Leukemic stem cells: from metabolic pathways and signaling to a new concept of drug resistance targeting

63%

Styczynski J., Drewa T.

Acta Biochimica Polonica

|

2007

|

tom 54

|

nr 4

717-726

Cancer stem cells are a small subset of cancer cells constituting a reservoir of self-sustaining cells with the exclusive ability to self-renew and maintain the tumor. These cells are identified by specific stem cell markers: antigens, molecules and signaling pathways. Transcription factors and molecules associated with oncogenesis, such as NF-κB, Bmi-1, Notch, WNT beta-catenin, Sonic hedgehog and their biochemical pathways, active only in a small minority of cancer cells might play key roles in determining the biology and the overall long-term behavior of a tumor. The molecules and pathways specific for cancer stem cells, which contribute to their drug resistance, are potential targets for new therapeutic strategies.

18

Dlaczego prognoza i sygnalizacja sa niezbedne w ochronie roslin

63%

Midura M.

Biuletyn Informacyjno-Handlowy. Ośrodek Doradztwa Rolniczego Boguchwała

|

2000

|

nr 06

14

19

High-throughput screening of stomatal responses to biotic stresses reveals new components of immune signalling

63%

McLachlan D., Bourdais G., Zhou J., Robatzek S.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

|

tom 94

|

nr 2

20

The toxic Doppelganger: on the ionic and molecular mimicry of cadmium

63%

Chmielowska-Bak J., Izbianska K., Deckert J.

Acta Biochimica Polonica

|

2013

|

tom 60

|

nr 3

Cadmium is a toxic heavy metal which can cause numerous alterations in cell functioning. Exposure to cadmium leads to generation of reactive oxygen species, disorders in membrane structure and functioning, inhibition of respiration, disturbances in ion homeostasis, perturbations in cell division, and initiation of apoptosis and necrosis. This heavy metal is considered a carcinogen by the Agency for Toxic Substances and Disease Registry. At least some of the described toxic effects could result from the ability of cadmium to mimic other divalent ions and alert signal transduction networks. This review describes the role of cadmium mimicry in its uptake, reactive oxygen species generation, alterations in calmodulin, Wnt/β-catenin and estrogen signaling pathways, and modulation of neurotransmission. The last section is dedicated to the single known case of a favorable function performed by cadmium mimicry: marine diatoms, which live in zinc deficient conditions, utilize cadmium as a cofactor in carbonic anhydrase - so far the only described cadmium enzyme.

Ograniczanie wyników

The role of the NUR77 family of nuclear receptors in the signalling pathways of thymocytes and neurons

Signalling protein inhibitors via the combinatorial modification of peptide scaffolds

Signalling pathways regulating transcription, mRNA stabilisation and intracellular transport of cytokines in activated mast cells

Signalling and multiple regulatory mechanisms for NADPH oxidase-mediated deliberate ROS production in plant cells

The cysteine-rich receptor-like kinase family in Arabidopsis – a phenotypic framework for stress responses and ROS signaling

Priming through H2O2-mediated signalling in Arabidopsis thaliana

Endocannabinoid signalling: a common target for high fat diets and substances of abuse?

Qa-SNARE protein SYP22 negatively regulates brassinosteroid signaling in the dark

Regulator of G-protein signalling expression and function in ovarian cancer cell lines

The involvement of PPAR-alpha and PPAR-gamma signalling in long-term changes in lipogenic enzyme gene expression, as observed in rat adipose tissue after food restriction