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The effect of a selective inhibition of potassium channels on the relaxation induced by nitric oxide in the human pregnant myometrium

100%

Modzelewska B., Kleszczewski T., Kostrzewska A.

Cellular and Molecular Biology Letters

2002

tom 07

nr Suppl.

Selective inhibition of guanylate cyclase prevents impairment of hypoxic pulmonary vasoconstriction in endotoxemic mice

84%

Spohr F., Busch C. J., Teschendorf P., Weimann J.

Journal of Physiology and Pharmacology

2009

tom 60

nr 2

107-112

Nitric oxide (NO) may cause sepsis-induced impairment of hypoxic pulmonary vasoconstriction (HPV). Although NO exerts many of its actions by activating soluble guanylate cyclase (sGC), there are several cGC-independent mechanisms that may lead to NO-induced vasodilation during endotoxemia. We investigated the role of sGC for the regulation of HPV during lipopolysaccharide (LPS) induced endotoxemia using 1H-(1,2,4)oxadiazole(4,3-)quinoxaline-1-one (ODQ), a specific inhibitor of sGC, in isolated, perfused, and ventilated mouse lungs. Without ODQ, lungs from LPS-challenged mice constricted significantly less in response to hypoxia as compared to lungs from mice not treated with LPS (26 ± 27% vs. 134 ± 37%, respectively, p < 0.05). 20 mg/kg ODQ, but not 2 mg/kg or 10 mg/kg, restored the blunted HPV response in LPS-challenged mice as compared to mice not challenged with LPS (80±14 % vs. 98±21 %). ODQ had no effect on baseline perfusion pressures under normoxic conditions. Analysis of pulmonary vascular P-Q relationships suggested that the restoration of pulmonary vascular response to hypoxia by ODQ is associated with a restoration of pulmonary vascular properties during normoxia. Our data show in a murine model that specific inhibition of sGC may be a new approach to restore HPV during endotoxemia.

Constitutive allelochemicals from Stratiotes aloides L.affect both biomass and community structure of phytoplankton

84%

Kufel L., Pasztaleniec A., Czapla G., Strzalek M.

Polish Journal of Ecology

2007

tom 55

nr 2

The paper presents the results of a study on allelopathic effect of extracts from Stratiotes aloides on natural lake phytoplankton communities grown outdoor in 40 l containers under natural light conditions. The water and plants were taken from an oxbow lake in spring (when S. aloides plants were submerged) and in summer (when plants were floating on lake water surface). Water extracts were prepared from fresh healthy leaves obtained on both sampling occasions. Control containers were supplemented with N and P in amounts similar to those introduced to experimental containers with macrophyte extracts. That way the experimental set up excluded the possibility of phytoplankton limitation by nutrients. Under such conditions the extracts from S. aloides strongly reduced phytoplankton biomass measured as the concentration of chlorophyll a (from 370 to 141 mg chl. a m⁻³ in spring and from 266 to 50 mg chl. a m⁻³ in summer). The inhibition of phytoplankton growth was indirectly confirmed by higher concentrations of available nutrients in experimental versus control containers. The extracts affected also the spring phytoplankton community structure by selective inhibition of diatoms and, to a less extent, of green algae and Cryptophyceae. Similar response of phytoplankton biomass to extracts obtained from submerged and floating S. aloides might suggest that allelochemicals were the constitutive part of macrophyte tissue and their production was not induced by competition between macrophyte and algae.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Journal of Physiology and Pharmacology

1 Polish Journal of Ecology

1 Busch C. J.

1 Czapla G.

1 Kleszczewski T.

1 Kostrzewska A.

1 Kufel L.

1 Modzelewska B.

1 Pasztaleniec A.

1 Spohr F.

1 Strzalek M.

1 Teschendorf P.

1 Weimann J.

1 2009

1 2007

1 2002

Wyniki wyszukiwania

The effect of a selective inhibition of potassium channels on the relaxation induced by nitric oxide in the human pregnant myometrium

Selective inhibition of guanylate cyclase prevents impairment of hypoxic pulmonary vasoconstriction in endotoxemic mice

Constitutive allelochemicals from Stratiotes aloides L.affect both biomass and community structure of phytoplankton