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1

Lack of salidroside impact on selected cytochromes encoding genes transcription in the liver of ethanol induced rats

100%
Kujawski R., Szulc M., Tobola M., Graczyk M., Czora-Poczwardowska K., Baraniak J., Kania-Dobrowolska M., Slynko-Krzyzostaniak J., Krajewska-Patan A., Mikolajczak P. L.
Herba Polonica
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2021
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tom 67
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nr 3
2
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Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

100%
Szulc M., Mularczyk P., Kujawski R., Gryszczynska A., Kaminska E., Geppert B., Baraniak J., Kania- Dobrowolska M., Ozarowski M., Krajewska-Patan A., Mikolajczak P. L.
Herba Polonica
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2018
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tom 64
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nr 1
In recent years, the search for potential neuroprotective properties of salidroside and its ability to influence the activity of nervous system become the subject of intense studies of many research groups. None of these studies, however, include an attempt to determine the effect of salidroside on the course of alcohol tolerance in vivo. The aim of this study was to investigate the ability of salidroside to inhibit the development of alcohol tolerance in rats, determining whether the effect of its action may occur in a dose-dependent manner, reducing both metabolic and central tolerance without affecting body temperature in control rats. Male Wistar rats were injected daily with ethanol at a dose of 3 g/kg for 9 consecutive days to produce ethanol tolerance. Salidroside in two doses (4.5 mg/kg and 45 mg/kg b.w.) or vehiculum was administered orally. On the 1st, 3rd, 5th and 8th day a hypothermic effect of ethanol was measured, while the loss of righting reflex procedure was performed on the 2nd, 4th, 6th and 7th day. On the 9th day rats were treated with salidroside, sacrificed 1 h after ethanol injections and blood was collected for blood-ethanol concentration measurement. Salidroside at a dose of 45 mg/kg inhibited the development of tolerance to hypothermic and sedative effects of ethanol, whereas insignificant elevation of blood-ethanol concentration was observed. The dose of 4.5 mg/kg b.w. had minimal effect, only small inhibition of tolerance to hypothermic action was observed. Salidroside affected neither body mass growth nor body temperature in non-alcoholic (control) rats.Results of the study indicate that salidroside at a dose of 45 mg/kg inhibited the development of tolerance to the hypothermic effect of ethanol. Observed inhibition of tolerance to the sedative effect of ethanol seems to be associated with salidroside influence on the central nervous system. A comprehensive explanation of the abovementioned observations requires further pharmacological and pharmacodynamic studies.
3

Glucosylation of p-tyrosol to salidroside by Rhodiola rosea L. cell cultures

100%
Furmanowa M., Hartwich M., Alfermann A. W.
Herba Polonica
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2002
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tom 48
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nr 2
Na drodze biotransformacji (glukozylacji) w hodowlach komórkowych Rhodiola rosea z p-tyrozolu wytwarzano salidrozyd. Substrat był przetwarzany w 57% po 72 godz. inkubacji. Obecność salidrozydu i p-tyrozolu stwierdzano przy użyciu TLC i RP-HPLC w przestrzeniach międzykomórkowych wszystkich komórek R. rosea. Zawartość salidrozydu kształtowała się w granicach 1,21-2,31% suchej masy komórek.
4

The influence of Rhodiola quadrifida 50 per cent hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice

84%
Skopinska-Rozewska E., Malinowski M., Wasiutynski A., Sommer E., Furmanowa M., Mazurkiewicz M., Siwicki A. K.
Polish Journal of Veterinary Sciences
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2008
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tom 11
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nr 2
97-104
The genus Rhodiola (Crassulaceae) consists of more than 100 species. They grow mainly in Tibet, China and Mongolia and are traditionally used as tonic, adaptogen , antidepressant and anti-inflammatory drugs. The best known is Rhodiola rosea (R. rosea) now cultivated also in Europe and North America, and present on the market as dietary supplement. Some authors reported anti-tumor activity of R. rosea extracts. Recently, we have published some data on immunomodulatory and antiangiogenic properties of R. rosea. Rhodiola quadrifida (R. quadrifida) belongs to the same family, but is almost not known in Europe, and there is no information about its possible anti-tumor as well as immunotropic and angiotropic activity. The aim of this study was to determine the influence of 50% hydro-alcoholic extract from rhizomes of R. quadrifida (Mongolian origin) and its main biologically active compound salidroside on tumor-induced angiogenesis. Angiogenesis was induced in the skin of Balb/c mice by grafting of syngeneic L-l sarcoma cells. Mice were fed R. quadrifida extract or salidroside in daily doses 40, 200 and 400 μg, or 0.5, 1, 2, and 4 μg, respectively. After 72 hours, mice were sacrificed with lethal dose of Morbital. All newly formed blood vessels were identified and counted in dissection microscope. Results: It was found that R. quadrifida extract and salidroside highly significantly decreased neovas- cular reaction in all doses applied.
5

Chemical investigations of biotransformed Rhodiola rosea callus tissue

84%
Krajewska-Patan A., Dreger M., Lowicka A., Gorska-Paukszta M., Mscisz A., Mielcarek S., Baraniak M., Buchwald W., Furmanowa M., Mrozikiewicz P. M.
Herba Polonica
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2007
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tom 53
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nr 4
The main aim of this study was to search the influence of exogenous addition of rosavin precursor: cinnamyl alcohol on the enhancing of rosavins content in callus culture of R. rosea, cultured on solid and liquid media (CCA). This is the first report – according to available literature – which concerns its biotransformation on solid medium conditions. The two strains of R. rosea tissue cultures showed different ability of cinnamyl alcohol glycosides production: both of them produced rosin (with or without supplementation), but the obtained level of rosavin production was notable higher in case of supplementation of the strain induced from axially buds of R. rosea. The exogenous cinnamyl alcohol was added into medium at concentration of 2.5 mM/L or 5 mM/L in the day of the inoculation. The application of 2.5 mM cinnamyl alcohol resulted in the increase of rosin content in the callus started from hypocotyle to very high levels: 1056.183 mg/100 g on solid medium and 776.330 mg/100 g in liquid medium. The content of rosavin showed the same growing tendency, but the final concentration of this phenylopropanoid in the supplemented callus tissue was about 7 times lower as compared to the roots of intact plant (63.603 mg/100 g). Addition of cinnamyl alcohol also enhanced rosarin biosynthesis but only in small amount: to 4.896 mg/100 g on solid medium. Callus tissue obtained from axially buds and treated by cinnamyl alcohol (2.5 mM) produced rosavin in a higher concentration: 92.801 mg/100 g and reached one fifth part of the amount produced by roots. The process of supplementation with cinnamyl alcohol influenced the enhanced biosynthesis of another bioactive substances as well (salidroside, tyrosol, chlorogenic acid). The obtained results confirmed that even on a solid medium the callus tissue can produce the characteristic active substances and the concentration of some of them, mainly rosin and rosavin, can be significantly improved by addition of the precursors to the medium.
6

Enhancing the biosynthesis of salidroside by biotransformation of p-tyrosol in callus culture of Rhodiola rosea L.

84%
Krajewska-Patan A., Furmanowa M., Dreger M., Gorska-Paukszta M., Lowicka A., Mscisz A., Mielcarek S., Baraniak M., Buchwalld W., Mrozikiewicz P. M.
Herba Polonica
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2007
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tom 53
|
nr 1
The aim of this research was to enhance the content of salidroside by exogenous addition of p-tyrosol in R. rosea tissue cultures. The callus tissue cultured on solid medium (MS with addition of NAA, BAP and adenine chloride) and compact callus agregate (CCA) were used in the experiments. The p-tyrosol was added to medium at a concentration of 5 mM/L (both into liquid and solid medium) and at concentration of 2.5 mM/L (only into liquid medium) in the day of the inoculation. The content of salidroside approximated: 23.15 mg/g (on solid medium) and 43.22 mg/g (CCA) after 7 days of 5 mM/L p-tyrosol application. The yield of salidroside was 3.1% (solid medium) and 4.3% (CCA). The addition of 2.5 mM tyrosol to CCA culture induced the increase of the content of salidroside to 34.73 mg/g and 3.5% yield of salidroside was obtained. The adverse effect was observed in biomass. Salidroside was not released into the medium.
7

Content of biologically active compounds in roseroot [Rhodiola sp.] raw material of different derivation

84%
Altantsetseg K., Przybyl J. L., Weglarz Z., Geszprych A.
Herba Polonica
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2007
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tom 53
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nr 4
Four populations of roseroot (Rhodiola rosea and Rh. quadrifida) originating from Poland and Mongolia were compared in respect of the content of main biologically active phenolic compounds (salidroside, p-tyrosol, trans-cinnamic alcohol, rosarin, rosavin and rosin) in the underground organs. Three solvents (75% ethanol, methanol and water) were used for the extraction of these phenolic compounds. Rh. rosea grown in Poland was characterised by similar content of salidroside and higher content of rosavin in comparison to the plants growing wild in Mongolia. The content of these compounds in Rh. quadrifida was lower than in Rh. rosea. Water appeared to be the best extraction medium for the isolation of salidroside and tyrosol. Cinnamic alcohol and its derivatives were more efficiently extracted with methanol and 75% ethanol.
8

Preliminary pharmacological investigations of biotransformed roseroot [Rhodiola rosea L.] callus tissue

84%
Krajewska-Patan A., Dreger M., Lowicka A., Gorska-Paukszta M., Mscisz A., Mikolajczak P. L., Buchwald W., Furmanowa M., Mrozikiewicz P. M.
Herba Polonica
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2008
|
tom 54
|
nr 3
Callus tissues from Rhodiola rosea L., a plant popular in traditional Russian and Asian medicine, treated with biosynthesis precursors of salidroside (p-tyrosol) and rosavins (cinnamic alcohol), were tested on the animals for the pharmacological activities of the extracts. Authors investigated the behavioural activity using locomotor activity and the motor coordination test. A single administration of extract from the callus tissue non treated with precursors resulted in stimulant effects on rats. The extract enriched in rosavins (after biotransformation) showed the inhibition of activity of tested animals. The more detailed studies concerning the exact nature of the effects especially after chronic administration are needed.
9

Callus tissues of Rhodiola kirilowii [Regel] Maxim. - dynamic of growth and active compounds production

67%
Krajewska-Patan A., Dreger M., Buchwald W., Gorska-Paukszta M., Mielcarek S., Baraniak M., Mscisz A., Furmanowa M., Mrozikiewicz P. M.
Herba Polonica
|
2009
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tom 55
|
nr 3
222-230
Rhodiola Kirilowii (Regel) Maxim. (Crassulaceae) is a traditional medicinal plant used in North Asia and China, especially in the cardiopulmonary disorders in the hypoxic conditions induced by high altitude. The presented results are the part of the investigations carried out in the Branch of Medicinal Plants of the Institute of Natural Fibres and Medicinal Plants in cooperation with the Department of Biology and Pharmaceutical Botany, Medical University in Warsaw on R. Kirilowii plants and tissue cultures. The aim of recent study was to determine the growth dynamics and active compounds production during the cultivation of callus tissues of R. Kirilowii on solid/liquid media. Tissue cultures of R. Kirilowii shown the ability to produce all the active compounds determined in the roots of plants of Polish origin. It is worth emphasizing, that rosavins, according to known literature, were not detected in roots of plants growing in Asia. The best time for collection the tissues from solid medium was fifth or sixth week of the culture – the tissues were growing dynamically and the contents of the main active compounds was high. The material from suspension should be collected in 12–15 days after inoculation. The obtained results will be applied in future investigations on the use of R. Kirilowii extracts in the experimental hypoxia in rats.
10
Content available remote

The cardiovascular effects of salidroside in the Goto-Kakizaki diabetic rat model

67%
Alameddine A., Fajloun Z., Bourreau J., Gauquelin-Koch G., Yuan M., Gauguier D., Derbre S., Ayer A., Custaud M. A., Navasiolava N.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 2
11

Contents of biologically active compounds in Rhodiola rosea roots during the vegetation period

67%
Buchwald W., Mscisz A., Krajewska-Patan A., Furmanowa M., Mielcarek S., Mrozikiewicz P. M.
Herba Polonica
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2006
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tom 52
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nr 4
Studies on the contents of phenylpropanoids, salidroside, tyrosol, epigallocatechin gallate and gallic acid in Rhodiola rosea roots during the vegetation period were carried out. Rosavin was the main compound of Rhodiola rosea roots. It was found that the time of harvest of roots had a significant effect on the contents of biologically active compounds.
12

Tissue culture of Rhodiola kirilowii [Regel.] Maxim - contents of biologically active compounds at different stages of growth

67%
Krajewska-Patan A., Furmanowa M., Mscisz A., Dreger M., Lowicka A., Gorska-Paukszta M., Mielcarek S., Mrozikiewicz P. M.
Herba Polonica
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2006
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tom 52
|
nr 4
The callus tissue obtained from Rhodiola Kirilowii (Regel.) Maxim was tested for growth dynamics and contents of active compounds. Biologically active compounds in the callus tissue were identified as salidroside, tyrosol, gallic acid, chlorogenic acid, caffeic acid and tannins. The lotaustralin was not detected either in the callus, or roots of R. Kirilowii
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