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Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group

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Misiura K., Wojcik M., Krakowiak A., Koziolkiewicz M., Pawlowska Z., Pluskota E., Cierniewski C. S., Stec W. J.

Acta Biochimica Polonica

1998

tom 45

nr 1

Dimethoxytritylphosphono-oligonucleotide conjugates have been prepared. They are totally resistant to nucleases present in human serum and do not affect cleavage of a complementary oligoribonucleotide by RNase H. Conjugates possessing a phosphate backbone gave better antisense inhibition of expression of plasminogen activator inhibitor type-1 within endothelial cells as compared with unconjugated oligonucleotides.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Cierniewski C. S.

1 Koziolkiewicz M.

1 Krakowiak A.

1 Misiura K.

1 Pawlowska Z.

1 Pluskota E.

1 Stec W. J.

1 Wojcik M.

1 1998

Wyniki wyszukiwania

Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group