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Cancer-associated retinopathy in patients with breast carcinoma

100%

Misiuk-Hojlo M., Ejma M., Gorczyca W. A., Szymaniec S., Witkowska D., Fortuna W., Miedzybrodzki R., Rogozinska-Szczepka J., Bartnik W.

Archivum Immunologiae et Therapiae Experimentalis

2007

tom 55

nr 4

Interactions between canthaxanthin and lipid membranes - possible mechanisms of canthaxanthin toxicity

84%

Sujak A.

Cellular and Molecular Biology Letters

2009

tom 14

nr 3

395-410

Canthaxanthin (β, β-carotene 4, 4′ dione) is used widely as a drug or as a food and cosmetic colorant, but it may have some undesirable effects on human health, mainly caused by the formation of crystals in the macula lutea membranes of the retina. This condition is called canthaxanthin retinopathy. It has been shown that this type of dysfunction of the eye is strongly connected with damage to the blood vessels around the place of crystal deposition. This paper is a review of the experimental data supporting the hypothesis that the interactions of canthaxanthin with the lipid membranes and the aggregation of this pigment may be the factors enhancing canthaxanthin toxicity towards the macula vascular system. All the results of the experiments that have been done on model systems such as monolayers of pure canthaxanthin and mixtures of canthaxanthin and lipids, oriented bilayers or liposomes indicate a very strong effect of canthaxanthin on the physical properties of lipid membranes, which may explain its toxic action, which leads to the further development of canthaxanthin retinopathy.

In vitro angiomodulatory activity of sera from type 2 diabetic patients with background retinopathy

67%

Chorostowska-Wynimko J., Skopinski P., Szaflik J., Partyka I., Duda-Krol B., Anuszewska E., Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

2005

tom 56

nr 4

65-70

Diabetic retinopathy is the leading cause of adult vision loss and blindness. The most important contributors to the development of diabetic retinopathy are hyperglycemia and hypoxemia that lead to increased vasopermeability, endothelial cell proliferation, and pathological neovascularization. In our previous studies, close relationship between proangiogenic activity of sera from type 2 diabetes mellitus patients (DM2) with background retinopathy, assessed in the in vivo serum-induced mouse cutaneous test (SIA), and VEGF and IL-18 serum concentration were observed. Moreover, it was clearly shown that IGF-1 might play an important role in the negative regulation of neoangiogenesis induced by DM2 patients' sera by diminishing the VEGF stimulatory effect. To confirm the observed phenomenon we evaluated the effect of DM2 patients' sera on the in vitro proliferative activity of human endothelial cells, which is critical for the sprouting and generation of new blood capillaries. Endothelial proliferative activity was significantly higher in the presence of sera from DM2 patients than from healthy controls (P<0.001), as estimated by the MTT test. Moreover, the examined sera from DM2 patients were characterized by increased IL-18 (P<0.05), diminished IGF-1 (P<0.02), and unchanged VEGF levels compared with those in controls. In conclusion, the present study showed a strong stimulatory effect of DM2 patients' sera on the proliferation of endothelial cells, which, along with the findings of our previous studies, proves that the described phenomenon is universal and valid for both animal and human endothelium.

Ograniczanie wyników

1 Archivum Immunologiae et Therapiae Experimentalis

1 Cellular and Molecular Biology Letters

1 Journal of Physiology and Pharmacology. Supplement

1 Anuszewska E.

1 Bartnik W.

1 Chorostowska-Wynimko J.

1 Duda-Krol B.

1 Ejma M.

1 Fortuna W.

1 Gorczyca W. A.

1 Miedzybrodzki R.

1 Misiuk-Hojlo M.

1 Partyka I.

1 Rogozinska-Szczepka J.

1 Skopinska-Rozewska E.

1 Skopinski P.

1 Sujak A.

1 Szaflik J.

1 Szymaniec S.

1 Witkowska D.

1 2009

1 2007

1 2005

Wyniki wyszukiwania

Cancer-associated retinopathy in patients with breast carcinoma

Interactions between canthaxanthin and lipid membranes - possible mechanisms of canthaxanthin toxicity

In vitro angiomodulatory activity of sera from type 2 diabetic patients with background retinopathy