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Clear cell renal carcinoma metastasis in the oral cavity - case report

100%

Milner P., Janas A., Grzesiak-Janas G.

Journal of Pre-Clinical and Clinical Research

2014

tom 08

nr 2

Introduction. Metastatic renal cell carcinoma can spread from the primary renal cell carcinoma to other organs, practically to all tissues. Distant metastases – to the tissue of the head and neck – are transferred through the blood and lymph vessels. A case of such a metastasis localized on the palate is relatively rare and therefore poses interesting material for description. Objective. Analysis of a case of cell renal carcinoma meastasis of the palate in a 67-year-old patient, based on clinical observations and medical publications. Conclusion. Clear cell carcinoma metastases to distant organs are often the first sign of a covertly progressing disease of which the primary tumour is localized in the kidney. The treatment is surgical, and prognosis is poor in the case of distant metastases since tumours recur even after a few years.

Diffusion-weighted MRI of kidney in the diagnosis of clear cell renal cell carcinoma of various grades of differentiation

63%

Mytsyk Y., Dutka I., Komnastka I., Gorecki A., Yuriy B., Shatynska-Mytsyk I.

Journal of Pre-Clinical and Clinical Research

2015

tom 09

nr 1

Introduction. Renal cell carcinoma (RCC) is the most common malignant epithelial tumour of the kidney, accounting for 85–90% of all solid renal tumours in adults and comprising 1–3% of all malignant visceral neoplasms. Recently, computed tomography (CT) has been considered the ‘gold standard’ in the diagnostic imaging of RCC; however, the use of CT is always associated with radiation exposure and consequently carries a significant increase in the risk of malignancy for patients with neoplastic processes. In recent years, magnetic resonance imaging (MRI) is increasingly attracting the attention of clinicians as the method of choice for the diagnosis and staging of RCC, due to several advantages over CT. Materials and method. The study involved 62 adult patients with a pathologically verified clear cell subtype of the renal cell carcinoma (ccRCC) and 15 healthy volunteers. All patients underwent renal MRI which included diffusion-weighted imaging (DWI) with subsequent apparent diffusion coefficient (ADC) measurement. Results. A significant difference was observed in the mean ADC value of the normal renal parenchyma and ccRCC – 1.82 ± 0.16 × 10– 3 mm2/s vs 2.15 ± 0.12 × 10– 3 mm2/s, respectively (р < 0,05). Additionally, statistically reliable differences in ADC values in patients with high and low ccRCC grades were obtained: in patients with the I grade, the mean ADC value was 1.92 ± 0.12 × 10– 3 mm2/s, in patients with the II grade, this value was 1.84 ± 0.14 × 10– 3 mm2/s, in patients with the III grade, the mean ADC value was 1.79 ± 0.12 × 10– 3 mm2/s, and in patients with the IV grade of nuclear polymorphism the mean ADC value was 1.72 ± 0.11 × 10– 3 mm2/s (p <0.05). Conclusions. The data obtained in the survey show a significant restriction in the diffusion of hydrogen molecules in tissues of ccRCC, compared to the healthy renal parenchyma due to the tumour’s greater density. A statistically significant difference was observed in the mean ADC values of ccRCC tumours with different Fuhrman nuclear grades: tumours with a low grade of differentiation demonstrated higher mean ADC values compared to highly differentiated tumours. Application of DWI modality of MR imaging with ADC calculation allows to obtain valuable information that is vital for the diagnosis of ccRCC and differentiation of its degree of malignancy.

Signal transduction in human tumor infiltrating lymphocytes

63%

Zocchi M. R., Poggi A., Crosti F., Tongiani S., Rugarli C.

Archivum Immunologiae et Therapiae Experimentalis

1993

tom 41

nr 1

Ograniczanie wyników

2 Journal of Pre-Clinical and Clinical Research

1 Archivum Immunologiae et Therapiae Experimentalis

1 Crosti F.

1 Dutka I.

1 Gorecki A.

1 Grzesiak-Janas G.

1 Janas A.

1 Komnastka I.

1 Milner P.

1 Mytsyk Y.

1 Poggi A.

1 Rugarli C.

1 Shatynska-Mytsyk I.

1 Tongiani S.

1 Yuriy B.

1 Zocchi M. R.

1 2015

1 2014

1 1993

Wyniki wyszukiwania

Clear cell renal carcinoma metastasis in the oral cavity - case report

Diffusion-weighted MRI of kidney in the diagnosis of clear cell renal cell carcinoma of various grades of differentiation

Signal transduction in human tumor infiltrating lymphocytes