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Changes of the expression of Lewis blood group antigens in glycoproteins of renal cancer tissues

100%

Borzym-Kluczyk M., Radziejewska I.

Acta Biochimica Polonica

2013

tom 60

nr 2

Sialic acid and sialyl Lewisa/x are found on N- and O-glycans of many human malignant cells. Carbohydrate antigens can be used as tumor markers, and an increase of their levels in cancer cells is associated with tumor progression. The aim of this study was to assess the level of some Lewis blood group antigens on glycoproteins in tumor (cancer tissue), intermediate zone (adjacent to tumor tissue), and normal renal cortex/medulla (uninvolved by tumor). The study was performed on tissues taken from 30 patients. Relative amounts of sugar structures of proteins with molecular masses above 30 kDa were determined by ELISA-like test with biotinylated lectins: MAA (Maackia amurensis), SNA (Sambucus nigra), and monoclonal antibodies anti-sialyl Lewisa/x. Higher expression of all examined structures was revealed in cancer tissues. Significant increases were observed for sialic acid linked α 2-3 in cancer tissues when compared to healthy ones and also among intermediate and healthy tissues. The sialic acid linked α 2-6 and sialyl Lewisx structures were significantly increased in cancerous cells when compared to normal and intermediate renal tissue. In case of sialyl Lewisa antigen, a significant difference was discovered between normal and intermediate tissue. Our results confirm that the examined Lewis antigens can be involved in tumor development. Their increase in cancer tissues can suggest their specific role in the process.

Levels of zinc, copper and selenium in subjects with diagnosed renal neoplasms

100%

Orlowski C., Matych J., Darago A., Jedrzejczak M., Sapota A.

Bromatologia i Chemia Toksykologiczna

2002

tom 35

nr 4

The aim of the study was to measure concentrations of selected essential elements (Zn, Cu, Se) in renal cortex and neoplastic tissue as well as their excretion in urine in subjects with diagnosed renal neoplasm. The study was performed in three groups: the investigated group (subjects with diagnosed renal neoplasm, who underwent single nephrectomy), the control group in vivo (healthy subjects), the control group post mortem (dead subjects). The levels of the tested elements in renal cortex in subjects with renal neoplasm did not differ basically from the levels observed in the control group post mortem, however they were significantly higher in renal cortex than in neoplastic tissue. This is particularly related to Zn, which is known to cumulate in renal cortex. In subjects with renal neoplasm increased excretion in urine of nearly all the tested elements was observed before nephrectomy. This phenomenon is most pronounced for whole protein and copper.

The enzymatic activity of type 1 iodothyronine deiodinase [D1] is low in liver hemangioma: a preliminary study

80%

Kornasiewicz O., Debski M., Stepnowska M., Szalas A., Bar-Andziak E., Krawczyk M.

Archivum Immunologiae et Therapiae Experimentalis

2010

tom 58

nr 1

77-80

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Archivum Immunologiae et Therapiae Experimentalis

1 Bromatologia i Chemia Toksykologiczna

1 Bar-Andziak E.

1 Borzym-Kluczyk M.

1 Darago A.

1 Debski M.

1 Jedrzejczak M.

1 Kornasiewicz O.

1 Krawczyk M.

1 Matych J.

1 Orlowski C.

1 Radziejewska I.

1 Sapota A.

1 Stepnowska M.

1 Szalas A.

1 2013

1 2010

1 2002

Wyniki wyszukiwania

Changes of the expression of Lewis blood group antigens in glycoproteins of renal cancer tissues

Levels of zinc, copper and selenium in subjects with diagnosed renal neoplasms

The enzymatic activity of type 1 iodothyronine deiodinase [D1] is low in liver hemangioma: a preliminary study