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Isolation of the DNA fragment reflecting the open reading frame II of the I-18 C gene of Chironomus tentans by the polymerase chain reaction. V. Different mechanisms of regulation regarding the open reading frames

100%

Borowicz B. P.

Journal of Plant Protection Research

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1997

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tom 37

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nr 1-2

Different mechanisms of regulation regarding the Open Reading Frames (ORFs) have been discussed to have a broader perspective that is necessary to evaluate the role of the ORFs of the I-18 C gene. This consideration includes the ORF II of the I-18 C gene which is the object of the presented research.

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Molecular mechanisms of regulation of CYP enzymes of phase I metabolism of xenobiotics - synthetic drugs and herbal preparations

84%

Bogacz A., Karasiewicz M., Kujawski R., Bartkowiak-Wieczorek J., Cichocka J., Kowalska A., Czerny B., Rudzinska K., Grzeskowiak E., Mrozikiewicz P. M.

Herba Polonica

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2012

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tom 58

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nr 3

The understanding of the pharmacokinetic properties of synthetic drugs as well as herbal preparations used in treatment of many diseases offers a real opportunity to eliminate or minimize the interaction between the active substances. This is of particular clinical importance because it can decrease or increase the action of drugs what is the major cause of failure of pharmacotherapy. Understanding the molecular basis of interaction of substances with enzymes of drug metabolism is extremely helpful in treatment planning and its practical application. The experimental and clinical studies aimed to complete the characterization of the mechanisms of many factors that modulate the activity of cytochrome P450 enzymes, can provide a lot of evidence guaranteeing the safety of herbal products.

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Magnesium and calcium concentrations in tissues of mice receiving manganese in food

67%

Boguszewska A., Pasternak K., Sztanke M., Borzecki A.

Polish Journal of Environmental Studies

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2004

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tom 13

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nr Suppl.2, Part 1

Manganese is very important trace element whose mechanism of actions involves activity regulation of enzymes taking part in key metabolic processes in organisms. It is a structural element of skin and bones, it also prevents osteoporosis. Its very important role in reproduction processes and in central nervous system has been already stated. The magnesium ion is of great importance in physiology by its intervention in 300 enzymatic systems, its membrane role and its function in neuromuscular excitability. The first pool of magnesium in organism is skeleton. The principal site of magnesium excretion are kidneys, which show important magnesium regulation mechanisms. For intestinal absorption, renal metabolism, bone accretion and resorption, magnesium shows analogies with calcium. Calcium is important macroelement in enzyme activation and inhibition, muscle and nerve function, and intracellular metabolism of all organisms. It is the main component of bones, where it is stored in organism. The aim of our work was to estimate influence of manganese chloride administration on concentrations of magnesium and calcium in mice tissues. Significant changes in magnesium and calcium content in dependence on the doses of administered manganese as well as the duration of the exposure have been stated in our experiment.

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Complex nature of enterococcal pheromone-responsive plasmids

67%

Wardal E., Sadowy E., Hryniewicz W.

Polish Journal of Microbiology

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2010

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tom 59

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nr 2

79-87

Pheromone-responsive plasmids constitute a unique group of ~ 20 plasmids identified, as yet, only among enterococcal species. Several of their representatives, e.g. pAD1, pCF10, pPD1 and pAM373 have been extensively studied. These plasmids posses a sophisticated conjugation mechanism based on response to sex pheromones - small peptides produced by plasmid-free recipient cells. Detailed analysis of regulation and function of the pheromone response process revealed its great complexity and dual role - in plasmid conjugation and modulation of enterococcal virulence. Among other functional modules identified in pheromone plasmids, the stabilization/partition systems play a crucial role in stable maintenance of the plasmid molecule in host bacteria. Among them, the par locus of pAD1 is one of the exceptional RNA addiction systems. Pheromone-responsive plasmids contribute also to enterococcal phenotype being an important vehicle of antibiotic resistance in this genus. Both types of acquired vancomycin resistance determinants, vanA and vanB, as well many other resistant phenotypes, were found to be located on these plasmids. They also encode two basic agents of enterococcal virulence, i.e. aggregation substance (AS) and cytolysin. AS participates in mating-pair formation during conjugation but can also facilitate the adherence of enterococci to human tissues during infection. The second protein, cytolysin, displays hemolytic activity and helps to invade eukaryotic cells. There are still many aspects of the nature of pheromone plasmids that remain unclear and more detailed studies are needed to understand their uniqueness and complexity.

5

Staphylococcal L-asparaginase: Catabolic repression of synthesis

67%

Rozalska M., Mikucki J.

Acta Microbiologica Polonica

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1992

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tom 41

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nr 3-4

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Place and mode of action of tumour suppressor gene[s] products within the cell cycle

59%

Horst A.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1994

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tom 42

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