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Immune responses in rats and sheep induced by a DNA vaccine containing the phosphoglycerate kinase gene of Fasciola hepatica and liver fluke infection

100%

Wesolowska A., Zawistowska-Deniziak A., Norbury L. J., Wilkowski P., Januszkiewicz K., Pyziel A. M., Zygner W., Wedrychowicz H.

Acta Parasitologica

2016

tom 61

nr 2

Excretory/secretory products of Fasciola hepatica but not recombinant phosphoglycerate kinase induce death of human hepatocyte cells

100%

Baska P., Norbury L. J., Wisniewski M., Januszkiewicz K., Wedrychowicz H.

Acta Parasitologica

2013

tom 58

nr 2

The liver fluke Fasciola hepatica infects a wide range of hosts, and has a considerable impact on the agriculture industry, mainly through infections of sheep and cattle. Further, human infection is now considered of public health importance and is hyperendemic in some regions. The fluke infection causes considerable damage to the hosts’ liver. However, the mechanisms of liver destruction have not yet been completely elucidated. In the present report we incubated a human liver cell line in the presence of either F. hepatica excretory/secretory material (FhES) or recombinant phosphoglycerate kinase (FhPGK). Dosedependent cytotoxicity in the presence of FhES was observed, indicating that FhES is capable of killing human hepatocytes, supporting a role for FhES in damaging host liver cells during infection; while treatment with a recombinant intracellular protein — FhPGK, had no impact on cell survival.

Ograniczanie wyników

2 Acta Parasitologica

2 Januszkiewicz K.

2 Norbury L. J.

2 Wedrychowicz H.

1 Baska P.

1 Pyziel A. M.

1 Wesolowska A.

1 Wilkowski P.

1 Wisniewski M.

1 Zawistowska-Deniziak A.

1 Zygner W.

1 2016

1 2013

Wyniki wyszukiwania

Immune responses in rats and sheep induced by a DNA vaccine containing the phosphoglycerate kinase gene of Fasciola hepatica and liver fluke infection

Excretory/secretory products of Fasciola hepatica but not recombinant phosphoglycerate kinase induce death of human hepatocyte cells