Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 12

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  reactive oxygen
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Glutathione: its role in the detoxication of reactive oxygen and environmental chemicals

100%
Parke D. V., Piotrowski J. K.
Acta Poloniae Toxicologica
|
1996
|
tom 04
|
nr 1
2
Content available remote

The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions

100%
Kwiecien S., Brzozowski T., Konturek P. C., Konturek S. J.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 4,2
The experimental model of acute gastritis such as water immersion restraint (WRS) stress-induced gastric injury is useful tool in examination of pathomechanism of acute gastritis. Nitric oxide (NO) plays an important role in the maintenance of gastric barrier, however, the interaction between reactive oxygen species (ROS) and NO on gastric mucosal integrity has been little studied. The purpose of our present study was to explain the participation of ROS in healing of WRS-induced gastric lesions accelerated by NO. Experiments were carrying out on 120 male Wistar rats. To assess gastric blood flow (GBF) laser Doppler flowmeter was used and the number of gastric lesions was counted in each stomach. The colorimetric assays were used to determine gastric tissue level of malondialdehyde (MDA) and 4- hydroxynonenal (4-HNE), the products of lipid peroxidation by ROS, as well as superoxide dismutase (SOD) activity, the enzyme scavanger of ROS. We demonstrated that 3.5 h of WRS resulted in appearance of acute gastric lesions accompanied by a significant decrease of GBF. Biological effects of ROS were estimated by measuring tissue levels of MDA and 4-HNE, as well as the SOD activity. It was demonstrated that 3.5 h of WRS led to significant increase of mucosal levels of MDA and 4-HNE, and it was accompanied by a decrease of SOD activity. Pretreatment with NO-donors (SIN-1, SNAP, nitroglycerin, NO-ASA) resulted in reduction in gastric lesion number, increment of GBF, decrease of MDA and 4-HNE tissue level and increase of SOD activity. Suppression of ROS plays an important role in the action of NO-donors on healing of acute gastric lesions induced by 3.5 h of WRS. NO-donors caused an attenuation of lipid peroxidation as documented by a decrease of MDA and 4-HNE levels and enhancement of antioxidative properties as evidenced by an increase of SOD activity.
3

A new physiological role of copper amine oxidases: cardioprotection against reactive oxygen intermediates

84%
Mateescu M. A., Dumoulin M. J., Wang X. T., Nadeau R., Mondovi B.
Journal of Physiology and Pharmacology. Supplement
|
1997
|
tom 48
|
nr 2
4

Accelerated oxidation of serum low density lipoprotein in gout and its improvement by allopurinol

84%
Tsutsumi Z., Yamamoto T., Takahashi S., Moriwaki Y., Yamakita J. I., Matsui K., Higashino K.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
5

Mechanisms for the generation of reactive oxygen species in plant defence response

84%
Wojtaszek P.
Biological Bulletin of Poznań. Supplement
|
1997
|
tom 34
6

Mechanisms for the generation of reactive oxygen species in plant defence response

84%
Wojtaszek P.
Acta Physiologiae Plantarum
|
1997
|
tom 19
|
nr 4
Recent data indicate that plants, in a manner similar to the situation found in mammalian phagocytotic cells, produce reactive oxygen species (ROS) in response to pathogen infection. This reaction could be very quick when using pre-existing, usually exocellular, components and/or, when biochemical machinery of the cell is activated, relatively late and long-lasting. The oxidative burst is defined as a rapid, transient production of high levels of ROS in response to external stimuli. Two major models depicting the origin of ROS in the oxidative burst are described, namely: the NADPH oxidase system and the pH-dependent generation of hydrogen peroxide by exocellular peroxidases. Additionally, the participation of exocellular ROS-generating enzymes, like germin-like oxalate oxidases and amine oxidases, in plant defence response is demonstrated. The involvement of protoplasmic ROS-generating systems is also indicated.
7

Silybin and silydianin diminish the oxidative metabolism of human polymorphonuclear neutrophils

84%
Ignatowicz E., Szaefer H., Zielinska M., Korczowska I., Fenrych W.
Acta Biochimica Polonica
|
1997
|
tom 44
|
nr 1
Silybin and silydianin exerted an inhibitory effect on superoxide radical production, peak chemiluminescence and hydrogen peroxide production in human polymorphonuclear neutrophils activated with opsonized zymosan.
8
Content available remote

Antioxidative enzymes activity and malondialdehyde concentration during mitoxantrone therapy in multiple sclerosis patients

67%
Adamczyk-Sowa M., Sowa P., Pierzchala K., Polaniak R., Labuz-Roszak B.
Journal of Physiology and Pharmacology
|
2012
|
tom 63
|
nr 6
9
Content available remote

Role of sensory nerves in gastroprotective effect of anandamide in rats

67%
Warzecha Z., Dembinski A., Ceranowicz P., Dembinski M., Cieszkowski J., Kownacki P., Konturek P. C.
Journal of Physiology and Pharmacology
|
2011
|
tom 62
|
nr 2
Previous studies have shown that stimulation of cannabinoid 1 (CB1) receptor protects the gastric mucosa against stress-induced lesion. Aim of the present study was to examine the influence of anandamide on lipid peroxidation and antioxidant defense system in gastric mucosa and the role of sensory nerves in gastroprotective effects of cannabinoids. Studies were performed on rats with intact or ablated sensory nerves (by neurotoxic doses of capsaicin). Gastric lesions were induced by water immersion and restrain stress (WRS). Anandamide was administered at the dose of 0.3, 1.5 or 3.0 µmol/kg, 30 min before exposure to WRS. CB1 receptor antagonist, AM251 (4.0 µmol/kg) was administered 40 min before WRS. WRS induced gastric lesions associated with the decrease in gastric blood flow, mucosal DNA synthesis and mucosal activity of superoxide dismutase (SOD). Serum level of interleukin-1ß (IL-1ß) and mucosal level of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were increased. Administration of anandamide reduced the ulcers area, generation of MDA+4-HNE and serum level of IL-1ß, and this effect was associated with the reduction in the WRS-induced decrease in gastric mucosal blood flow, mucosal DNA synthesis and SOD activity. Ablation of sensory nerves increased the area of ulcers, serum level of IL-1ß and mucosal content of MDA+4-HNE, whereas mucosal DNA synthesis, SOD activity and blood flow were additionally decreased. In rats with ablation of sensory nerves, administration of anandamide at the high doses (1.5 and 3.0 µmol/kg) partly reduced deleterious effect of WRS on gastric mucosa, but this effect was weaker than in animals with intact sensory nerves. Low dose of anandamide (0.3 µmol/kg) was ineffective in the protection of gastric mucosa against the WRS-induced lesions in rats with ablation of sensory nerves. In rats with intact sensory nerves and exposed to WRS, administration of AM251 exhibited deleterious effect. In rats with ablation of sensory nerves and exposed to WRS, AM251 failed to affect mucosal injury in the stomach. We conclude that anandamide reduces the mucosal oxidative stress and exhibits gastroprotective effect against WRS-induced ulcers. These effects are partly mediated by sensory nerves.
10

The effects of MK-801 and U-83836E on post-ischemic reperfusion injury in rat brain

67%
Durmaz R., Inal M., Angin K., Atasoy M. A., Altinisik M., Tel E.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 2
11

Reactive oxygen intermediates and serum antioxidative system in patients with chronic C hepatitis treated with IFN-alpha and thymus factor X

67%
Jablonowska E., Tchorzewski H., Lewkowicz P., Kuydowicz J.
Archivum Immunologiae et Therapiae Experimentalis
|
2005
|
tom 53
|
nr 6
12

Reactive oxygen species as second messengers? Induction of the expression of yeast catalase T gene by heat and hyperosmotic stress does not require oxygen

67%
Krawiec Z., Bilinski T., Schuller C., Ruis H.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 1
It is shown that oxygen is not absolutely needed for stress-induced synthesis of catalase T in the yeast Saccharomyces cerevisiae. Yeast cells develop heat resistance after exposure to elevated temperatures in anoxia. The levels of catalase activity and thermotolerance are comparable to those in aerobically stressed cells. While these results obviously do not exclude a stress signaling role of reactive oxygen species in some systems, as postulated by other authors, they suggest that the question of the obligatory requirement for reactive oxygen species in other stress signaling systems should be rigorously re-investigated.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.