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5',8-cyclo-2'-deoxyadenosine [cdA] formation by gamma-radiation. Theoretical quantum mechanics study

100%

Karwowski B. T., Grand A., Cadet J.

Acta Biochimica Polonica

2009

tom 56

nr 4

655-662

Reactions of reactive oxygen species and more specifically - of hydroxyl radical (•OH) - with nucleosides may lead to the generation of radicals in the base and 2-deoxyribose moieties. In the present study emphasis was put on the possible reaction modes of 2'-deoxyadenosine (dA) radicals, leading to the formation of related 5',8-cyclonucleosides. It appears that the prerequisite for the formation of 5',8-cyclo-2'-deoxyadenosine (cdA) is the adoption of O4'-exo conformation by 2-deoxyribose; however, this is the least energetically favored conformer among the different puckered forms adopted by the furanose ring. The O4'-exo conformation was found to be present in each of the discussed mechanisms.

Molecular modeling of singlet-oxygen binding to anthraquinones in relation to the peroxidating activity of antitumor anthraquinone drugs

84%

Liwo A., Jeziorek D., Ossowski T., Dyl D., Tempczyk A., Tarasiuk J., Nowacka M., Borowski E., Woznicki W.

Acta Biochimica Polonica

1995

tom 42

nr 4

Anthraquinone derivatives are important anti-cancer drugs possessing, however, undesirable peroxidating and, in consequence, cardiotoxic properties. This results from the mediation by these compounds of the one-electron reduction processes of the oxygen molecule, which produces the highly toxic superoxide anion radical and other active oxygen species. This article summarizes the results of our studies on the molecular aspects of the mechanism of anthraquinone-mediated peroxidation which were carried out using enzymatic-assay, electrochemical, and quantum-mechanical methods.

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Mechanika osrodkow komorkowych i granularnych

67%

Gozdz A.

Acta Agrophysica

1999

tom 24

57-65

W pracy przedstawiono zarysy metody jednolitego opisu ośrodków granularnych i komórkowych. Formalizm wykorzystuje elementy mechaniki kwantowej chociaż można go zakwalifikować do metod mikroskopowo-makroskopowych, Pozwala on modelować własności ośrodka bazując na znajomości fenomenologicznych oddziaływań pomiędzy jego granulami lub komórkami.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Acta Agrophysica

1 Borowski E.

1 Cadet J.

1 Dyl D.

1 Gozdz A.

1 Grand A.

1 Jeziorek D.

1 Karwowski B. T.

1 Liwo A.

1 Nowacka M.

1 Ossowski T.

1 Tarasiuk J.

1 Tempczyk A.

1 Woznicki W.

1 2009

1 1999

1 1995

Wyniki wyszukiwania

5',8-cyclo-2'-deoxyadenosine [cdA] formation by gamma-radiation. Theoretical quantum mechanics study

Molecular modeling of singlet-oxygen binding to anthraquinones in relation to the peroxidating activity of antitumor anthraquinone drugs

Mechanika osrodkow komorkowych i granularnych