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Effects of acetylsalicylic acid and a new pyrazine derivative PD-101 on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes

100%

Wozniak A., Limon J., Petrusewicz J., Kaliszan R.

Journal of Applied Genetics

1998

tom 39

nr 3

Acetylsalicylic acid (ASA) and α-2-pyrazylidene-α-cyano N-butyl acetamide (PD-101), a new antiaggregatory pyrazine derivative were tested for their genotoxicity in human lymphocytes in vitro using the sister chromatid exchange (SCE) technique. Both compounds were found to be inactive in inducing SCE in concentration from 1 µM up to 1000 µM. The agents displayed inhibitory effect on cell kinetics.

Ograniczanie wyników

1 Journal of Applied Genetics

1 Kaliszan R.

1 Limon J.

1 Petrusewicz J.

1 Wozniak A.

1 1998

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Effects of acetylsalicylic acid and a new pyrazine derivative PD-101 on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes