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The effect of cytochrome P450 inducers and phenolic antioxidants on lipid peroxidation and glutathione peroxidase in rat liver and kidney

100%

Murias M., Jodynis-Liebert J., Baer-Dubowska W.

Acta Poloniae Toxicologica

2000

tom 08

nr 1

Effect of natural phenols on the catalytic activity of cytochrome P450 2E1

100%

Mikstacka R., Gnojkowski J., Baer-Dubowska W.

Acta Biochimica Polonica

2002

tom 49

nr 4

The effect of protocatechuic acid, tannic acid and trans-resveratrol on the activity of p-nitrophenol hydroxylase (PNPH), an enzymatic marker of CYP2E1, was examined in liver microsomes from acetone induced mice. trans-Resveratrol was found to be the most potent inhibitor (IC50 = 18.5 ± 0.4 uM) of PNPH, while protocatechuic acid had no effect on the enzyme activity. Tannic acid with IC50 = 29.6 ± 3.3 uM showed mixed- and trans-resveratrol competitive inhibition kinetics (Ki = 1 uM and 2.1 uM, respectively). Moreover, trans-resveratrol produced a NADPH-dependent loss of PNPH activity, suggesting mechanism-based CYP2E1 inactivation. These results indicate that trans-resveratrol and tannic acid may modulate cytochrome P450 2E1 and influence the metabolic activation of xenobiotics mediated by this P450 isoform.

Aktywnosc mikrobiologiczna i cytotoksycznosc wybranych kwasow fenolowych w testach in vitro

88%

Czechowska S. K., Markiewicz R., Borawska M. H.

Bromatologia i Chemia Toksykologiczna

2009

tom 42

nr 3

959-964

Wystepowanie kwasow aromatycznych i cukrow w kwiatach Centaurea cyanus L

63%

Swiatek L., Zadernowski R.

Acta Academiae Agriculturae ac Technicae Olstenensis. Technologia Alimentorum

1993

tom 25

231-239

Ograniczanie wyników

1 Acta Academiae Agriculturae ac Technicae Olstenensis. Technologia Alimentorum

1 Acta Biochimica Polonica

1 Acta Poloniae Toxicologica

1 Bromatologia i Chemia Toksykologiczna

2 Baer-Dubowska W.

1 Borawska M. H.

1 Czechowska S. K.

1 Gnojkowski J.

1 Jodynis-Liebert J.

1 Markiewicz R.

1 Mikstacka R.

1 Murias M.

1 Swiatek L.

1 Zadernowski R.

1 2009

1 2002

1 2000

1 1993

Wyniki wyszukiwania

The effect of cytochrome P450 inducers and phenolic antioxidants on lipid peroxidation and glutathione peroxidase in rat liver and kidney

Effect of natural phenols on the catalytic activity of cytochrome P450 2E1

Aktywnosc mikrobiologiczna i cytotoksycznosc wybranych kwasow fenolowych w testach in vitro

Wystepowanie kwasow aromatycznych i cukrow w kwiatach Centaurea cyanus L