Wyniki wyszukiwania

1

Evolutionary principles for generating protein mimetics: Directed assembly of peptide loops on topological templates

100%

Banfi D., Mandal B., Mutter M., Patiny L.

Acta Biochimica Polonica

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2001

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tom 48

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nr 4

A novel methodology for the reversible competitive condensation of peptide loops to chemoreactive topological templates is presented.

2

Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein

63%

Wedzony K., Chocyk A., Kolasiewicz W., Mackowiak M.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 4

The present study was designed to investigate whether serotonin 5-HT1A receptor protein (5-HT1A receptor-immunoreactivity), is present on cortical pyramidal neurons of the rat medial prefrontal cortex (MPC) innervating the ventral tegmental area (VTA). Recent data stress the role of serotonin 5-HT1A receptors in the pathology of schizophrenia, and in the mechanism of action of novel antipsychotic drugs. It was found that approximately 52% of cells in layers II/III of the MPC whose axons initial segments were immunoreactive for serotonin 5HT1A receptor were also labeled with Fluoro-Gold (FG), a retrograde tracer injected into the VTA, indicating that certain portion of neurons forming glutamatergic innervations of the VTA may be controlled by serotonin 5-HT1A receptors. In deep cortical layers (V/VI) retrogradely labeled neurons never colocalized with serotonin 5-HT1A receptor-mmunoreactivity. These anatomical data indicate that serotonin 5-HT1A receptors might potentially control the excitability and propagation of information transmitted by the pyramidal cells to the VTA. Moreover, our results indicate that the drugs operating via serotonin 5-HT1A receptors in the MPC, might control from this level the release of glutamate in the VTA and restore function of glutamate neurotransmission, whose dysfunction is observed for example in schizophrenia.

3

SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses

51%

Johnson R. D., Oliver P. L., Davies K. E.

Acta Biochimica Polonica

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2008

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tom 55

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nr 4

619-628

Much of the focus of neurobiological research into schizophrenia is based on the concept that disrupted synaptic connectivity underlies the pathology of the disorder. Disruption of synaptic connectivity is proposed to be a consequence of both disrupted synaptic transmission in adult hood and abnormalities in the processes controlling synaptic connectivity during development of the central nervous system. This synaptic hypothesis fits with neurodevelopmental models of schizophrenia and our understanding of the mechanisms of antipsychotic medication. This conceptual model has fostered efforts to define the exact synaptic pathology further. Synaptic proteins are obvious candidates for such studies, and the integral role of the SNARE complex, and SNARE-associated proteins, in synaptic transmission will ensure that it is the focus of much of this research. Significant new insights into the role of this complex are arising from new mouse models of human disease. Here the evidence from both animal and human clinical studies showing that the SNARE complex has a key role to play in the aetiology and pathogenesis of schizophrenia is discussed.

4

Polymorphism of gonadotropin action; molecular mechanisms and clinical implications

51%

Huhtaniemi I. T.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 3

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Acta Neurobiologiae Experimentalis

1 Journal of Physiology and Pharmacology

1 Banfi D.

1 Chocyk A.

1 Davies K. E.

1 Huhtaniemi I. T.

1 Johnson R. D.

1 Kolasiewicz W.

1 Mackowiak M.

1 Mandal B.

1 Mutter M.

1 Oliver P. L.

1 Patiny L.

1 Wedzony K.

1 2008

1 2007

1 2001

1 1996

Evolutionary principles for generating protein mimetics: Directed assembly of peptide loops on topological templates

Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein

SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses

Polymorphism of gonadotropin action; molecular mechanisms and clinical implications