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1

Alteration of sphingolipid biostat in experimental model of oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPPplus)

100%
Pyszko J., Strosznajder J. B.
Acta Neurobiologiae Experimentalis
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2013
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tom 73
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nr 1
Bioactive sphingolipids are important molecules that control wide spectrum of neuronal processes including neurotransmission, synaptic function, cells proliferation and death. Sphingosine kinases (SK1/2) are conserved enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which acts as a primary and secondary messenger. S1P binds to 5 receptors and plays essential role in neural signal transduction under physiological and various pathological conditions. Although growing evidence suggests important role of SK1/2 and S1P in neurodegenerative disorders including ischemia, inflammation and Alzheimer’s Disease, till now disturbances of sphingolipids homeostasis in Parkinson’s Disease (PD) remain unknown. Our study try to explain the role of SK1/2 and S1P in molecular mechanism of cell survival and death in model of oxidative stress evoked by neurotoxin 1-methyl-4-phenylpyridinium (MPP+), compound widely used in experimental model of PD. Our data presented that MPP+, comparable to SK inhibition evoked death of human neuroblastoma cells SH-SY5Y in time and concentration dependent manner. These changes are accompanied by increased free radicals concentration in these cells. Reduced level of SK1 protein was detected in SH-SY5Y cells after 24h exposure to MPP+ comparing to control. Moreover S1P pretreatment enhanced survival of these cells and protein level of SK1 comparing to MPP+ treated cells. Our data indicated that MPP+ evoked neuronal death is mediated by SK1/2 inhibition and altered sphingolipids signaling. These molecular events lead to caspase dependent apoptotic cells death and poly(ADP-ribose) polymerase-1 (PARP-1) degradation. All above results presented the alteration of sphingolipid biostat in experimental model of PD and suggested that S1P can offer novel, protective strategy.Supported by NCN Grant 5870/B/PO1/2011/40
2

Wyrob miesiaca Firefly - system zapobiegania pozarom

100%
W K.
Biuletyn Informacyjny Ośrodka Badawczo-Rozwojowego Przemysłu Płyt Drewnopochodnych w Czarnej Wodzie
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2000
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tom 41
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nr 4
222-223
3

The influence of peroxidation processes on gastric mucosa protective system in rat

100%
Lutnicki K., Szpringer E.
Journal of Physiology and Pharmacology. Supplement
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2001
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tom 52
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nr 2
4

Local water quality monitoring on surroundings of the sanitary landfill

80%
Koda E.
Annals of Warsaw Agricultural University. Land Reclamation
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2004
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tom 35a
5

Biological support of a potato protection system against the Colorado beetle (Leptinotarsa decemlineata Say) in Belarus

80%
Brechko E.
Progress in Plant Protection
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2012
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tom 52
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nr 4
In the article, the results of long-term research (2006–2010) on biological substantiation and the improved potato protection system against Colorado beetle in Belarus are presented. The system is based on age and the phenotypic structure of the phytophage population definition, and their resistance monitoring to pyrethroids by frequency of phenomorph №3 occurrence. The system includes a pre-planting tuber treatment, or spraying growing plants with different preparations. The economic expediency thresholds of insecticidal protection depending on weather conditions, varietal features, planned productivity, and a special-purpose designation of the crop cultivated in different agroclimatic zones were taken into account. Now, the improved system of potato protection against the pest is widely promoted on the farms of the Republic.
6

Influence of vertical barrier surrounding old sanitary landfill on eliminating transport of pollutants on the basis of numerical modelling and monitoring results

80%
Koda E.
Polish Journal of Environmental Studies
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2012
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tom 21
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nr 4
This paper presents results of the numerical modeling of pollution transport and groundwater quality monitoring for an old sanitary landfill where an advanced protection system has been introduced. The protection system consists of a vertical bentonite barrier and peripheral leachate drainage. The 3-D FEMWATER numerical program has been used for the groundwater flow and transport simulation. The local monitoring program includes chemical analyses of surface and ground water leachate concentration as well as groundwater level observations. The modeling and monitoring results were aimed at the assessment of the vertical barrier effectiveness as a groundwater protection system in landfill surroundings. These analyses were performed for the Radiowo landfill located near Warsaw. This site was established in 1962, and the permission for its exploitation was extended to the end of 2010. The landfill remedial works have been conducted since 1998 and include: installation of the vertical bentonite barrier, the leachate drainage system, the leachate recirculation system, the mineral cover, the degassing system, and the regulation of water relations in surroundings. The influence of remedial works on groundwater quality on landfill surroundings also has been analyzed in the paper.
7

The sources of natural antioxidants

70%
Sikora E., Cieslik E., Topolska K.
Acta Scientiarum Polonorum. Technologia Alimentaria
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2008
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tom 07
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nr 1
Intensive oxidative processes occuring in human organism lead to formation of oxygen reactive forms, which can damage systemic cells and tissues. It is shown, that body endogenous protective system can be supported in that case by natural antioxidant compounds provided from food. The assessment of food products as the potential sources of antioxidants was performed, taking into consideration the kinds of compounds supplied, and their significance in the diet of different nations.
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