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1

Surgical treatment and ethanol injections in hyperplastic prostate in dogs

100%
Juodziukyniene N., Vaitkus V., Aniuliene A.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 03
301-304
The aim of the study was to evaluate the effect of two different methods of partial prostatectomy, to evaluate the influence of 96° ethanol injection on hyperplastic prostate and to compare the efficacy of ethanol injection with the efficacy of surgical treatment of the prostate. The study was performed in the years 20012003 in the surgical department of Dr. L. Kriauèeliûnas Small Animal Clinic. The surgical treatment (prostatectomy) was performed on 8 dogs using 2 methods: fillet and subcapsular. We compared the effectiveness and postoperative hystological evaluation of bioptats one and two weeks after surgery. We have performed ethanol injection on 5 dogs and evaluated the histological feature of prostatic tissues after injection to measure the effect of ethanol. The fillet method is technically simpler, shorter and the tissues of the prostate heal more quickly. Ethanol injection induces multi-focular coagulative necrosis, followed by fibrosis and atrophy of the prostate. This way of treatment is simpler and easier because there are no sections through prostate tissues. To avoid a section of the abdominal wall, a transurethral catheter can be used for the ethanol injection.
2

Tumor vaccines for the management of prostate cancer

100%
McNeel D. G., Disis M. L.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
tom 48
|
nr 2
3

Combined effects of radiotherapy and photodynamic therapy on an in vitro human prostate model

84%
Colasanti A., Kisslinger A., Quarto M., Riccio P.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 4
Human prostate cancer cells were evaluated for growth after photodynamic therapy, radiotherapy, and combined treatment. Indocyanine green was tested as a photosensitizer and radiosensitizer. Two human cell lines were used: PC-3 derived from prostate carcinoma, and EPN derived from normal prostate tissue. The light source used for the photoactivation experiments was a diode laser peaked at 805 nm. The light dose incident on cells was 108 J/cm2. Ionizing radiation was produced by a linear accelerator, and the dose was 2, 4 and 6 Gy. Cytotoxicity was evaluated by measuring the colony forming ability of cells. Our results show that indocyanine green induces cell death by photoactivation, but it does not act as a radiosensitizer if used with ionizing radiation. The combined treatment of photodynamic therapy and radiotherapy produces an additive effect which does not depend on the sequence of the two treatments. Combined treatments could be more useful since they allow the reduction of the ionizing radiation
4

Prostate specific antigen levels after acute myocardial infarction

67%
Acikgoz S., Can M., Dogan S. M., Mungam G., Aydin M., Kelek S., Sumbuloglu V.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 4
Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of prostatic tissue. In some case reports, changes in PSA levels after acute myocardial infarction (AMI) have been reported. In this study we evaluated variations in PSA levels post-AMI. Twenty-six male patients who had PSA levels within reference limits were included in the study. The diagnosis of AMI was confirmed by clinical findings, ECG (electrocardiogram) and cardiac marker studies. Serum total PSA (tPSA) and free PSA (fPSA) levels were measured at days 0 (day of admission), 1, 2 and 3 after AMI. PSA/albumin ratio was also calculated in order to evaluate the effect of dilution. A statistical analysis of the results of all patients revealed significant decrease in tPSA levels and tPSA/Albumin ratio at day 2 when compared to days 0 and 3, which showed a similar pattern. Changes of fPSA and fPSA/ Albumin ratio according to days were not found significant. In only four patients we found increased levels of tPSA and increased fPSA levels in three of them. These patients displayed severe problems such as renal failure, cardiac failure, ventricular aneurysm and cerebral ischemia due to cardiac arrest. The lower tPSA levels on day 2 suggest that tPSA can be eliminated rapidly from the circulation on days 1 and 2, probably through the formation of complexes of tPSA with acute phase proteins.
5

Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells

59%
Ligeza J., Ligeza J., Klein A.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 3
Autocrine growth factors produced by epithelial cells mediate the development and proliferation of neoplastic human prostate tissue. Various approaches have been used to down-regulate neoplastic growth of prostate cancer using natural flavonoids, soluble receptors, pseudo-ligands, monoclonal antibodies and tyrosine kinase inhibitors (tyrphostins). Selected growth factor/growth factor receptor loops (mainly TGFα/EGFR and IGFs/IGFIR) have been proposed as regulators of prostate cancer cell growth. We have previously determined that blockade of IGFIR or VEGF2R signaling pathways by tyrphostin AG1024 and SU1498 inhibits autocrine growth and viability of DU145 cells in vitro. Recently, we compared the activity of AG1024 and SU1498 with the inhibiting effect of tyrphostin A23 (a selective inhibitor of EGFR). The results described in this paper confirm that DU145 cells do not produce IGFI or EGF. In contrast, DU145 cells produce a great amount of VEGF, much more than TGFα (about 60-fold), and VEGF may be the real autocrine growth factor of the investigated cells. The results indicate that the growth of DU145 may be regulated by at least three autocrine loops: TGFα/EGFR, IGFII/IGFIR and VEGF/VEGFR2. Neither AG1024 nor SU1498 affected the production of TGFα substantially, which excludes the possibility that IGFRs or VEGFR2 inhibitors arrest the growth of these cells by inhibition of synthesis and/or secretion of TGFα. The obtained data indicate that all tree investigated tyrphostins (AG1024, SU1498 and A23) inhibit signal transmission by Akt (PKB), ERK(1/2), Src and STAT in a similar manner. A comparison of the effects of the investigated tyrphostins indicates that TGFα, IGFII and VEGF stimulate cell growth by affecting the same signaling pathway. The hypothesis was confirmed by the effect of the investigated tyrphostins on activation of EGFR. All these inhibitors decreased phosphorylation of EGFR to the same extent, and after the same time of incubation with cell culture. These results strongly suggest that stimulation of EGFR kinase is the main step in the initiation of mitogen signaling in DU145 cells, regardless of the type of ligand (TGFα, IGFs or VEGF) and their specific receptors.
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