Wyniki wyszukiwania

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TIVA - znieczulenie calkowicie dozylne jako alternatywa dla znieczulenia wziewnego

100%

Siewruk K., Mastalerz T.

Magazyn Weterynaryjny

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2010

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tom 19

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nr 08

850-852

2

Comparative study of midazolam-propofol and metamizole-propofol clinical effects in domestic pigeons

72%

Mousavi A., Abedi G., Jahandideh A., Hesaraki S.

Medycyna Weterynaryjna

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2018

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tom 74

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nr 09

This study was conducted to determine the quality of anesthesia by evaluating the clinical effects of midazolam-propofol and metamizole-propofol on domestic pigeons (Columba livia). The aim of the study was to choose an appropriate injectable anesthetic protocol by utilizing midazolam and metamizole as pre-anesthetic drugs in order to reduce the dose of propofol and decrease side effects. Eighteen male pigeons weighing 304.2 ± 32.3 g (mean ± SD) were randomly allocated to three groups of six pigeons each. Midazolam (6 mg/kg/IM) and metamizole (500 mg/kg/IM) were used five minutes prior to administration of propofol (8 mg/kg/IV) in groups I and II, respectively, while the birds in group III (control group) received metamizole (500 mg/kg/IM). Five minutes after the last injection, clinical parameters of various systems were evaluated. Nervous system parameters declined in groups I and II, while reflexes could still be elicited in group III (P < 0.05). There were no significant changes in the heart rate, dysrhythmia, or gastrointestinal parameters in the three groups (P > 0.05). The birds in group II showed reduced jaw and limb muscle tone (P < 0.05). Corneal and palpebral reflexes were absent in groups I and II (P < 0.05). Both respiratory depth and pattern were irregular in group I, while all the parameters were normal in group II (P < 0.05). The respiratory rate decreased in all groups after injection, although this reduction was significant only in group I (P < 0.05). In conclusion, the combination of metamizole-propofol is safer and more compatible with the physiology of pigeons and can be used for short operations, especially when inhalation agents are contraindicated.

3

Badania porownawcze nad ultrakrotkotrwajacymi znieczuleniami ogolnymi u psow

72%

Lipp J.

Annales Universitatis Mariae Curie-Skłodowska. Sectio DD:Medicina Veterinaria

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1995

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tom 50

179-194

4

"Ketofol" - sposób na bezpieczną indukcję znieczulenia?

72%

Januchta M., Mastalerz T.

Magazyn Weterynaryjny

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2014

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tom 23

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nr 02

5

Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia - induced acute lung injury

72%

Gokcinar D., Ergin V., Cumaoglu A., Menevse A., Aricioglu A.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

Intravenous lipopolysaccharide (LPS) leads to acute lung injury (ALI) in rats. The purpose of this study was to examine the anti-inflammatory and antioxidant efficacy of ketamine, propofol, and ketofol in a rat model of ALI. We induced ALI in rats via intravenous injection of LPS (15 mg kg-1). The animals were randomly separated into five groups: control, LPS only, LPS + ketamine (10 mg·kg-1·h-1), LPS + propofol (10 mg·kg-1·h-1), LPS + ketofol (5 mg·kg-1·h-1 ketamine + 5 mg·kg-1·h-1 propofol). LPS resulted in an increase in the release of pro-inflammatory cytokines, mRNA expression related with inflammation, production of nitric oxide, and lipid peroxidation. Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue. Propofol decreased the levels of cytokines in plasma and lung tissue, whereas it had no effect on the IL-1-beta level in lung tissue. Ketamine downregulated mediators of lung tissue inflammation and reduced the level of circulating cytokines and protected lung tissue against lipid peroxidation. Ketofol decreased the level of TNF-α and IL-1β in plasma, as well as expression of cyclooxygenase-2 mRNA and the nitrate/nitrite level in lung tissue. The results of this investigation support the hypothesis that ketamine may be effective in preventing ALI.

6

Propofol protects rat astroglial cells against tert-butyl hydroperoxide-induced cytotoxicity; the effect on histone and cAMP-response-element-binding protein (CREB) signalling

72%

Holownia A., Mroz R. M., Wielgat P., Skiepko A., Sitko E., Jakubow P., Kolodziejczyk A., Braszko J. J.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 4

63-69

Propofol can be potentially beneficial in oxidative stress related malignancies as neurodegenerative diseases and traumatic brain injury but its signalling pathways are poorly understood. In this study effect of propofol on astroglial signalling in oxidative stress was evaluated. Ten days old cultures of rat astroglial cells were treated for 1 hour with t-butyl hydroperoxide (tBHP) to induce oxidative stress following by 1 hour propofol. We measured cytotoxicity, changes in cell growth and apoptosis as well as alterations in expression and acetylation of chromatin core H3 and H4 histone proteins and changes in native and phosphorylated cAMP-response-element-binding protein (CREB). tBHP induced limited cytotoxicity, increased apoptosis, decreased glutamine synthetase and enolase activities, decreased nuclear CREB, CREB-P and histone proteins but unchanged cytosolic CREB and histone acetyltransferase (HDAC) expression. Propofol clearly protected the cells against tBPH-induced toxicity, normalized alterations in cell growth, restored to some extent glial enzyme activities and reduced apoptotic cell numbers. Also, propofol restored H3 but not H4 expression/activation, but was without effect on decreased nuclear CREB expression/activation. These data show that oxidative stress in cultured astroglia significantly affects nuclear CREB and histone proteins and point to the protective role of propofol.

7

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Safe and effective anaesthesiological protocols in domestic pig

72%

Mikolajczyk A.

Annals of Warsaw University of Life Sciences - SGGW. Animal Science

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2016

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tom 55[2]

Safe and effective anaesthesiological protocols in domestic pig.The aim of this study was to establish a neuroleptanalgesic protocol anda general anaesthetic protocol in domestic pigs. The study was approved by approved by the Local Ethical Commission of the University of Warmia and Mazury in Olsztyn (the permit no. 73/2015). Fifteen juvenile female crossbred gilts were used. The drugs used in intramuscularly injection were: atropine (0.035 mg/kg b.w.), ketamine (7.0 mg/kg b.w.), medetomidine (0.063 mg/kg b.w.). The main anaesthetic drug, propofol, was given intravenously for induction and maintenance of general anaesthesia. To achieve the adequate neuroleptanalgesia the animals required in intramuscular injection atropine, ketamine and medetomidine mixing in the same syringe. The average time from muscular injection to the point at which pigs remained laterally recumbent was 1.95 ± 0.72 min. The average time from muscular injection to the point at which pigs managed to stand in recovery was 75.80 ± 13.14 min. To achieve the general anaesthesia the pigs required atropine, ketamine, medetomidine and propofol. Premedication with mixture of atropine, ketamine and medetomidine was achieved rapidly after intramuscular injection. All pigs became recumbent within 1.20 ± 0.19 min without any signs of excitement. The average time from muscular injection to the point at which pigs remained laterally recumbent was 2.06 ± 0.67 min. The induction dose of propofol was 4.5 mg/kg b. w.. Anaesthesia was maintained with propofol 2.0 mg/kg b.w.. During the surgery no complications occurred intraoperatively concerning. Concluding the findings demonstrate that the proposed protocols permits to obtain a safe and effective neuroleptanalgesia and general anaesthesia in swine and can be useful in biomedical investigations. A short-lasting time for recumbency after intramuscularly injection of atropine, ketamine and medetomidine mixture injection can allow optimizing the workflow of clinical practice in a laboratory animal farm.

8

58%

Guzel O., Inal G., Cirakli Z. T., Eraslan E., Aktas M.

Medycyna Weterynaryjna

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2006

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tom 62

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nr 12

1383-1386

The effects of propofol and sevoflurane anesthesia on heart rate and respiratory rate, body temperature, plasma Ca, P, Na, K, Mg, creatinine, urea, ALT, APT, ALP, GGT, LDH in rabbits have been assessed. This study was carried out on 12 New Zealand White rabbits. Anesthesia induction was performed using propofol, which was slowly administered via IV injection at a dose of 10 mg/kg. Sevoflurane inhalation was administered at an initial concentration of 5%, followed by 2% for anesthesia maintenance. While causing a decrease in heart rate and respiratory frequency, propofol application but did not affect body temperature and hematocrite value. Sevoflurane did not alter heart rate, although it caused respiratory depression and a decrease in body temperature. Propofol-sevoflurane anesthetic combination caused some alterations in ALT and GGT liver enzymes and plasma phosphorus levels. In the light of the findings, the animals had a reliable and controlled anesthesia with the propofol-sevoflurane combination. However, it should be taken into consideration that this combination may impair the electrolyte balance and cause respiratory depression. Thus it has been concluded that a diligent monitorization and an electrolyte support is essential during the period of anesthesia.

14

Propofol alters vesicular transport in rat cortical neuronal cultures

58%

Turina D., Bjornstrom K., Sundovist T., Eintrei C.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 1

Neuronal intracellular transport is performed by motor proteins, which deliver vesicles, organelles and proteins along cytoskeletal tracks inside the neuron. We have previously shown that the anesthetic propofol causes dose- and time-dependent, reversible retraction of neuronal neurites. We hypothesize that propofol alters the vesicular transport of cortical neurons due to this neurite retraction. Primary cultures of co-cultivated rat cortical neurons and glial cells were exposed to either 2 µM propofol, control medium or the lipid vehicle, in time-response experiments. Reversibility was tested by washing propofol off the cells. The role of the GABAA receptor (GABAAR) was assessed with the GABAAR antagonist gabazine. Vesicles were tracked using differential interference contrast video microscopy. Propofol caused a retrograde movement in 83.4±5.2% (mean±S.E.M.) of vesicles, which accelerated over the observed time course (0.025±0.012 µm·s-1). In control medium, vesicles moved predominantly anterograde (84.6±11.1%) with lower velocity (0.011±0.004 µm·s-1). Cells exposed to the lipid vehicle showed the same dynamic characteristics as cells in control medium. The propofol-induced effect on vesicle transport was reversible and blocked by the GABAAR antagonist gabazine in low concentration. Our results show that propofol causes a reversible, accelerating vesicle movement toward the neuronal cell body that is mediated via synaptic GABAAR. We have previously reported that propofol initiates neurite retraction, and we propose that propofol causes vesicle movement by retrograde flow of cytoplasm from the narrowed neurite.

15

Evaluation of medetomidine-midazolam-atropine (MeMiA) anesthesia maintained with propofol infusion in New Zealand White rabbits

58%

Rozanska D.

Polish Journal of Veterinary Sciences

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2009

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tom 12

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nr 2

209-216

An anesthetic combination of medetomidine-midazolam-atropine and propofol was investigated in twenty New Zealand White rabbits. Each rabbit received combined medetomidine at a dosage of 0.2 mg/kg (b.w.), midazolam (0.5 mg/kg b.w.) and atropine (0.5 mg/kg b.w.) intramuscularly for induction of anesthesia. Propofol was administered intravenously - given to effect, and after that by an infusion pump to maintain anesthesia. The influence of the anesthetic combination on the cardiopulmonary system was evaluated by monitoring respiratory and heart rates, blood pressure, and arterial blood gas tensions. The results obtained showed that propofol infusion at a rate of 0.5 mg/kg b.w./min maintained general anesthesia effectively with few side effects on the cardiopulmonary system during 30 minutes. However, slight hypotension, hypercapnia, and respiratory acidosis were associated with infusion of this anesthetic. The recovery of the rabbits from the anesthesia was smooth. Two rabbits died 20 to 24 hours after anesthesia. In conclusion, an anesthetic combination with medetomidine-midazolam-atropine and propofol at the investigated doses was shown to be a safe method to induce and maintain general anesthesia enabling short-term surgical procedures in healthy animals.

16

Stan padaczkowy jako częsty stan nagły u psów - predyspozycje, przyczyny, postępowanie

58%

Pawelec H., Pomianowski A.

Magazyn Weterynaryjny

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2016

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tom 25

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nr 02

17

Źrebię to nie "taki mały koń" - specyfika znieczulenia ogólnego źrebiąt. Cz.II. Przebieg znieczulenia

58%

Szmigielska M., Biazik A., Henklewski R.

Magazyn Weterynaryjny

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2014

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tom 23

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nr 11

18

TIVA - znieczulenie calkowicie dozylne jako alternatywa dla znieczulenia wziewnego

Comparative study of midazolam-propofol and metamizole-propofol clinical effects in domestic pigeons

Badania porownawcze nad ultrakrotkotrwajacymi znieczuleniami ogolnymi u psow

"Ketofol" - sposób na bezpieczną indukcję znieczulenia?

Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia - induced acute lung injury

Propofol protects rat astroglial cells against tert-butyl hydroperoxide-induced cytotoxicity; the effect on histone and cAMP-response-element-binding protein (CREB) signalling

Safe and effective anaesthesiological protocols in domestic pig

Specyfika znieczulenia ogólnego kotów - cz.IV. Aspekty kliniczne. Indukcja i znieczulenie ogólne

Plytkie znieczulenie u zolwi wodnych i jaszczurek

In vitro delivery accuracy of Computer Controlled Infusion Pump (CCIP) software linked to an Alaris® GH syringe pump for propofol target-controlled infusion in dogs

Znieczulenie ogolne propofolem w leczeniu przepuklin swin metoda laparoskopowa

Znieczulenie zlozone z udzialem atropiny, midazolamu i propofolu w zabiegach artroskopowych u psow

Effects of propofol and sevoflurane anesthesia on some physiological and biochemical parameters in rabbits

Propofol alters vesicular transport in rat cortical neuronal cultures

Evaluation of medetomidine-midazolam-atropine (MeMiA) anesthesia maintained with propofol infusion in New Zealand White rabbits

Stan padaczkowy jako częsty stan nagły u psów - predyspozycje, przyczyny, postępowanie

Źrebię to nie "taki mały koń" - specyfika znieczulenia ogólnego źrebiąt. Cz.II. Przebieg znieczulenia

Wplyw atropiny, medetomidyny, propofolu i atipamezolu na parametry hemodynamiczne psow

Metody znieczulenia infuzyjnego u małych zwierząt

Znieczulenie zrównoważone u koni