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Plasminogen activator inhibitor-1 [PAI-1] gene 4G-5G promoter polymorphism is not associated with breast cancer

100%

Blasiak J., Smolarz B.

Acta Biochimica Polonica

2000

tom 47

nr 1

The antigen content of plasminogen activator inhibitor-1 (PAI-1) in primary breast cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumors predict poor prognosis for patients. The gene encoding PAI-1 is highly polymorphic and an insertion (5G)/deletion (4G) polymorphism in the PAI-1 gene promoter (the 4G/5G polymorphism), may have functional significance in PAI-1 expression. In the present work the distribution of genotypes and frequency of alleles of the 4G/5G polymorphism in subjects with breast cancer were investigated. Tumor tissues were obtained from 100 postmenopausal women with node-negative and node-positive ductal breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The 4G/5G polymorphism was determined by PCR amplification using the allele specific primers. The distribution of the genotypes of the 4G/5G polymorphism in both control and patients did not differ significantly (P > 0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distributions and allele frequencies between node-positive and node-negative patients. The 4G/5G polymorphism may not be linked with elevated level of PAI-1 observed in breast cancer and therefore may not be associated with appearance and/or progression of breast cancer.

Adipohormones as prognostic markers in patients with nonalcoholic steatohepatitis [NASH]

80%

Krawczyk K., Szczesniak P., Kumor A., Jasinska A., Omulecka A., Pietruczuk M., Orszulak-Michalak D., Sporny S., Malecka-Panas E.

Journal of Physiology and Pharmacology. Supplement

2009

tom 60

nr 3

71-75

Plasminogen activator inhibitor 1 [PAI-1] 1334G-A genetic polymorphism in colorectal cancer

80%

Smolarz B., Romanowicz-Makowska H., Kulig A.

Acta Biochimica Polonica

2003

tom 50

nr 2

Plasminogen activator inhibitor 1 (PAI-1) content in colorectal cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumours predict poor prognosis. The gene encoding PAI-1 is highly polymorphic and PAI-1 gene variability could contribute to the level of PAI-1 biosynthesis. In the present work the distribution of genotypes and frequency of alleles of the 1334G/A polymorphism in 92 subjects with colorectal cancer in samples of cancer tissue and distant mucosa samples as well as in blood were investigated. Blood samples age matched healthy individuals (n = 110) served as control. The 1334G/A polymorphism was determined by PCR amplification using allele specific primers. No differences in the genotype distributions and allele frequencies between blood, distant mucosa samples and cancer tissue were detected. However, the distribution of the genotypes of the 1334G/A polymorphism in patients differed significantly (P < 0.05) from those predicted by the Hardy-Weinberg equilibrium. There were significant differences in the frequencies of alleles between the colorectal cancer subjects and controls (P < 0.05). The results support the hypothesis that the 1334G/A polymorphism may be associated with the incidence of colorectal cancer.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology. Supplement

2 Smolarz B.

1 Blasiak J.

1 Jasinska A.

1 Krawczyk K.

1 Kulig A.

1 Kumor A.

1 Malecka-Panas E.

1 Omulecka A.

1 Orszulak-Michalak D.

1 Pietruczuk M.

1 Romanowicz-Makowska H.

1 Sporny S.

1 Szczesniak P.

1 2009

1 2003

1 2000

Wyniki wyszukiwania

Plasminogen activator inhibitor-1 [PAI-1] gene 4G-5G promoter polymorphism is not associated with breast cancer

Adipohormones as prognostic markers in patients with nonalcoholic steatohepatitis [NASH]

Plasminogen activator inhibitor 1 [PAI-1] 1334G-A genetic polymorphism in colorectal cancer