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Pre-eclampsia-associated alterations in Wharton's jelly proteoglycans

100%

Gogiel T., Galewska Z., Jaworski S.

Acta Biochimica Polonica

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2005

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tom 52

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nr 2

Proteoglycans of Wharton’s jelly contain mainly chondroitin/dermatan sulphate chains. The predominant proteoglycan is decorin (core proteins of 45 and 47 kDa), although the core proteins of biglycan (45 kDa), versican (260 kDa) and of other proteoglycans (90, 110, 220 kDa) were also detected (Gogiel et al., 2003). The aim of the present study was to compare the proteoglycan composition of Wharton’s jelly of newborns delivered by healthy mothers and those with pre-eclampsia. Proteoglycans from pre-eclamptic Wharton’s jelly had a higher sulphated glycosaminoglycan/protein ratio than those of normal tissue. Pre-eclampsia is associated with a lower level of all proteoglycan core proteins, especially those of higher molecular mass (such as versican), although the same set of core proteins were found in normal and pre-eclamptic Wharton’s jelly. The alterations in the proteoglycan composition of Wharton’s jelly may affect the mechanical properties of the umbilical cord and, in the case of pre-eclampsia, disturb foetal blood circulation.

2

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Blood serum microRNA profiles of pregnant women as biomarkers of pre-eclampsia evaluation

86%

Kondracka A., Jaszczuk I., Koczkodaj D., Filip A., Kwasniewska A.

Journal of Pre-Clinical and Clinical Research

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2020

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tom 14

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nr 4

3

Physiopathology of human embryonic implantation: clinical incidences

72%

Merviel P., Lourdel E., Cabry R., Boulard V., Brzakowski M., Demailly P., Brasseur F., Copin H., Devaux A.

Folia Histochemica et Cytobiologica

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2009

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tom 47

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nr 5

4

Mimicking of glutathione peroxidase deficiency by exposition of JAR cells to increased level of synthetic hydroperoxide

72%

Hallmann A., Milczarek R., Szkatula M., Wozniak M., Spodnik J. H., Klimek J.

Folia Morphologica

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2005

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tom 64

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nr 4

304-308

A short chain synthetic analogue of lipid hydroperoxides was used to overload glutathione peroxidase (GPx) in human choriocarcinoma cell line JAR cells. Cells exposed to 100 µM tBuOOH displayed a 40% reduction in ATP level and significantly increased in membrane permeability, visualised by the lactate dehydrogenase (LDH) release into the extracellular medium. The intracellular level of oxygen free radicals measured as an oxidation of the dichlorodihydro-fluorescein diacetate (H₂DCF-DA) significantly increased after 2 hours of cell exposition to 100 µM tBuOOH. Concomitantly MDA, 4-HNE level increased to 2 nmol/mg of cell protein after 2 hours. Mitochondria stained with MitoTracker Red CMXRos displayed a filamentous appearance in control cells but changed into granular less energised organelles after exposition to tBuOOH. Collectively, the above results indicate the importance of the contribution of oxidative stress in the development of pre-eclampsia.

5

The concentrations of soluble HLA-G protein are elevated during mid-gestation and decreased in pre-eclampsia

72%

Darmochwal-Kolarz D., Kolarz B., Rolinski J., Leszczynska-Gorzelak B., Oleszczuk J.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 2

6

Collagen of umbilical cord vein and its alterations in pre-eclampsia

72%

Romanowicz L., Jaworski S.

Acta Biochimica Polonica

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2002

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tom 49

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nr 2

The state of the vascular system of the mother and of placenta is known to exert a great influence on intrauterinal development of the fetus. Pre-eclampsia is the most common pathological syndrome connected with pregnancy. Since collagen is one of the main constituents of the vessel wall a comparison was made with collagen content and its molecular polymorphism in umbilical cord veins of newborns from healthy and pre-eclamptic mothers. It was found that umbilical cord veins of newborns from mothers with pre-eclampsia contained 18% less collagen than those of the newborns from normal pregnancies. This decrease was accompanied by a slight decrease of collagen solubility, but all its types (I, III, IV, V and VI) were present. However, the umbilical vein wall of newborns from mothers with pre-eclampsia contained relatively less of type I and more of type III collagen than the normal umbilical cord. These differences may be connected with a disturbance of blood flow in fetus of a woman with pre-eclampsia.

Ograniczanie wyników

Pre-eclampsia-associated alterations in Wharton's jelly proteoglycans

Blood serum microRNA profiles of pregnant women as biomarkers of pre-eclampsia evaluation

Physiopathology of human embryonic implantation: clinical incidences

Mimicking of glutathione peroxidase deficiency by exposition of JAR cells to increased level of synthetic hydroperoxide

The concentrations of soluble HLA-G protein are elevated during mid-gestation and decreased in pre-eclampsia

Collagen of umbilical cord vein and its alterations in pre-eclampsia