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The microRNA pathway in plants

100%

Laubinger S.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

2013

tom 94

nr 3

Regulation of lncRNA expression

84%

Wu Z., Liu X., Liu L., Deng H., Zhang J., Xu Q., Cen B., Ji A.

Cellular and Molecular Biology Letters

2014

tom 19

nr 4

Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.

An approach for the identification of microRNA with an application to Anopheles gambiae

84%

Chatterjee R., Chaudhuri K.

Acta Biochimica Polonica

2006

tom 53

nr 2

MicroRNAs (miRNAs) are an abundant class of 20-27 nt long noncoding RNAs, involved in post-transcriptional regulation of genes in eukaryotes. These miRNAs are usually highly conserved between the genomes of related organisms and their pre-miRNA transcript, about 60-120 nt long, forms extended stem-loop structure. Keeping these facts in mind miRsearch is developed which relies on searching the homologues of all known miRNAs of one organism in the genome of a related organism allowing few mismatches depending on the phylogenetic distance between them, followed by assessing for the capability of formation of stem-loop structure. The precursor sequences so obtained were then screened through the RNA folding program MFOLD selecting the cut-off values on the basis of known Drosophila melanogaster pre-miRNAs. With this approach, about 91 probable candidate miRNAs along with pre-miRNAs were identified in Anopheles gambiae using known D. melanogaster miRNAs. Out of these, 41 probable miRNAs have 100% similarity with already known D. melanogaster miRNAs and others were found to be at least 85% similar to the miRNAs of various other organisms.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

1 Cellular and Molecular Biology Letters

1 Cen B.

1 Chatterjee R.

1 Chaudhuri K.

1 Deng H.

1 Ji A.

1 Laubinger S.

1 Liu L.

1 Liu X.

1 Wu Z.

1 Xu Q.

1 Zhang J.

1 2014

1 2013

1 2006

Wyniki wyszukiwania

The microRNA pathway in plants

Regulation of lncRNA expression

An approach for the identification of microRNA with an application to Anopheles gambiae