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The renal actions of oxytocin in the conscious rat

100%

Windle R. J., Forsling M. L.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 4

The renal actions of oxytocin were studied in the conscious unrestrained rat infused with 0.077 M saline at a rate of 150 µl/min. During the control period volume and sodium excretion reached stable equilibria, the rates being equal to those infused. Administration of oxytocin at 200 pmol/min produced plasma oxytocin levels of 26.0±2.1 pmol/1 and caused a significant diuresis and natriuresis. Renal responses could also be seen with a lower dose of 30 pmol/min which produced plasma levels of 5.1 ±0.5 pmol/1 while a dose of 15 pmol/min which produced no significant increase in the plasma oxytocin had no renal effect. It appears that oxytocin has a natriuretic action in concentrations within the physiological range.

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Influence of hydration state on hormonal responses to exercise in dogs

100%

Baker M. A., Doris P. A., Turlejska E.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 3

The purpose of these studies was to determine how plasma levels of arginine vasopressin (pAVP) are related to workload, plasma osmolality (pOsm), blood volume (BV) and plasma angiotensin II (pAII) in exercising dogs. Measurements were made in dogs running on a treadmill at 7.5 km. hr⁻¹ at slopes of 0, 10% and 20% when they were hydrated ad lib and when they had been deprived of drinking water and also in dogs running on a 20% slope after an IV infusion of hypertonic NaCl. Dehydration increased pOsm by 6.6% and reduced BV by 10% in resting dogs. In dehydrated animals, pAVP, pAII and pOsm were elevated above hydrated levels at rest and during exercise at all three workloads. In hydrated dogs, pOsm rose during exercise at 10% and 20% slopes but pAVP rose above resting levels only at the highest workload and pAII was not affected by exercise. In dehydrated dogs, pOsm and pAVP rose during exercise at 10% and 20% slopes and pAII was elevated at the 20% slope. BV decreased during exercise at the highest workload in both hydrated and dehydrated animals. After hypertonic NaCl, pAVP rose during exercise but pOsm and pAII did not. The results suggest that both osmotic and nonosmotic factors contribute to the release of AVP in exercising dogs and that exercise leads to a leftward shift in the relationship of pAVP to pOSM which could be a result of reduced blood volume.

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Leucocytosis, thrombocytosis, and plasma osmolality during rest and exercise: an hypothesis

84%

McKenzie M. A., Greenleaf J. E., Looft-Wilson R., Barnes P. R.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 2

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Control of neurohypophysial hormone secretion, blood osmolality and volume in pregnancy

59%

Brunton P. J., Arunachalam S., Russell J. A.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 8

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

1 Arunachalam S.

1 Baker M. A.

1 Barnes P. R.

1 Brunton P. J.

1 Doris P. A.

1 Forsling M. L.

1 Greenleaf J. E.

1 Looft-Wilson R.

1 McKenzie M. A.

1 Russell J. A.

1 Turlejska E.

1 Windle R. J.

1 2008

1 1999

2 1991

The renal actions of oxytocin in the conscious rat

Influence of hydration state on hormonal responses to exercise in dogs

Leucocytosis, thrombocytosis, and plasma osmolality during rest and exercise: an hypothesis

Control of neurohypophysial hormone secretion, blood osmolality and volume in pregnancy