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The renal actions of oxytocin in the conscious rat

100%

Windle R. J., Forsling M. L.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 4

The renal actions of oxytocin were studied in the conscious unrestrained rat infused with 0.077 M saline at a rate of 150 µl/min. During the control period volume and sodium excretion reached stable equilibria, the rates being equal to those infused. Administration of oxytocin at 200 pmol/min produced plasma oxytocin levels of 26.0±2.1 pmol/1 and caused a significant diuresis and natriuresis. Renal responses could also be seen with a lower dose of 30 pmol/min which produced plasma levels of 5.1 ±0.5 pmol/1 while a dose of 15 pmol/min which produced no significant increase in the plasma oxytocin had no renal effect. It appears that oxytocin has a natriuretic action in concentrations within the physiological range.

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On the metabolism of prostaglandin E1 administered intravenously to human volunteers

100%

Peskar B. A., Cawello W., Rogatti W., Rudofsky G.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 3

We have demonstrated recently the formation of a biologically active metabolite of prostaglandin (PG) E₁, 13,14-dihydro-PGE₁, during intravenous infusions of PGE₁ in patients with peripheral arterial occlusive disease. We have now investigated the levels of the immediate precursor of 13,14-dihydro-PGE₁ , the biologically inactive 15-keto-13,14-dihydro-PGE₁, during intravenous administration of 20 pig, 40pig or 80 pig PGE₁ over a period of 60 min to human volunteers. It was found that levels of 15-keto-13,14- -dihydro-PGE₁, but not those of PGEx itself, increased in a dose-dependent manner. Thus, increased formation of 13,14-dihydro-PGE₁ from 15-keto- 13,14-dihydro-PGE₁ with increasing doses of PGE₁ can be expected to occur. It remains to be investigated, to which extent formation of small amounts of 13,14-dihydro-PGE₁ during intravenous infusion of PGE₁ could contribute to the therapeutic effects of PGE₁ in patients with peripheral arterial occlusive disease.

3

Age dependence of plasma endothelin levels in glaucoma patients

100%

Konieczka K., Terelak-Borys B., Skonieczna K., Schoetzau A., Grabska-Liberek I.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 6

4

Plasma levels of Abeta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease

100%

Sobow T., Flirski M., Kloszewska I., Liberski P. P.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 2

5

Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats

100%

Iciek M., Chwatko G., Lorenc-Koci E., Bald E., Wlodek L.

Acta Biochimica Polonica

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2004

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tom 51

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nr 3

The redox status of plasma thiols can be a diagnostic indicator of different pathological states. The aim of this study was to identify the age dependent changes in the plasma levels of total, free and protein bound glutathione, cysteine and homocysteine. The determination was conducted in plasma of three groups of rats: 1) young (3-month-old), 2) middle aged (19-month-old), and 3) old (31-month-old). Total levels of glutathione, cysteine and homocysteine and their respective free and protein-bound fractions decreased with age. The only exception was a rise in free homocysteine concentration in the middle group, which indicates a different pattern of transformations of this thiol in plasma. The drop in the level of protein-bound thiols suggests that the antioxidant capacity of plasma diminishes with age, which, consequently, leads to impaired protection of -SH groups through irreversible oxidation. The plasma sulfane sulfur level also declines with age, which means that aging is accompanied by inhibition of anaerobic sulfur metabolism.

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Elevated advanced oxidation protein products levels in patients with liver cirrhosis

84%

Zuwala-Jagiello J., Pazgan-Simon M., Simon K., Warwas M.

Acta Biochimica Polonica

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2009

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tom 56

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nr 4

679-685

Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.

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Pain and mobility improvement and MDA plasma levels in degenerative osteoarthritis, low back pain, and rheumatoid arthritis after infrared A-irradiation

84%

Siems W., Bresgen N., Brenke R., Siems R., Kitzing M., Harting H., Eckl P. M.

Acta Biochimica Polonica

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2010

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tom 57

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nr 3

Infrared (IR)-A irradiation can be useful in back and musculoskeletal pain therapy. In this study joint and vertebral column pain and mobility were measured during two weeks of IR-A irradiation treatment of patients suffering from degenerative osteoarthritis of hip and knee, low back pain, or rheumatoid arthritis. Additionally, before and after IR-A treatment MDA serum levels were measured to check if MDA variations accompany changes in pain intensity and mobility. Two-hundred and seven patients were divided into verum groups getting IR-irradiation, placebo groups getting visible, but not IR irradiation, and groups getting no irradiation. In osteoarthritis significant pain reduction according to Visual Analogue Scale and mobility improvements occurred in the verum group. Even though beneficial mean value changes occurred in the placebo group, the improvements in the placebo and No Irradiation groups were without statistical significance. In low back pain, pain and mobility improvements (by 35-40 %) in the verum group were found, too. A delayed (2nd week) mobility improvement in rheumatoid arthritis was seen. However, pain relief was seen immediately. In patients suffering from low back pain or rheumatoid arthritis, the pain and mobility improvements were accompanied by significant changes of MDA serum levels. However, MDA appears not a sensitive biofactor for changes of the pain intensity in degenerative osteoarthritis. Nevertheless, unaffected or lowered MDA levels during intensive IR-A therapy argue against previous reports on free radical formation upon infrared. In conclusion, rapid beneficial effects of IR-A towards musculoskeletal pain and joint mobility loss were demonstrated.

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Pretreatment levels of vascular endothelial growth factor in plasma predict a complete remission rate and time to relapse or progression in patients with diffuse large B-cell lymphoma

84%

Lech-Maranda E., Bienvenu J., Broussais-Guillaumot F., Michallet A.-S., Warzocha K., Bilinski P., Boyle P., Coiffier B., Salles G.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

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nr 2

9

Plasma level of protein C, fibrinogen concentration, and platelet number in dogs with Leg-Calve-Perthes disease and osteochondrosis. Preliminary studies

84%

Szponder T., Wessely-Szponder J.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 3

The possible role of coagulatory disorders in pathogenesis of Legg-Calve-Perthes disease (Lepo) and osteochondrosis (OC) was examined. A decrease in protein C level in dogs with LCPD (94.31±4.74%) in comparison with healthy dogs (95.8±6.35%) was observed. Moreover, in OC affected animals, the value varied between 92.25±2.5% and 94.33±5.5%. The mean plasma fibrinogen level in control group was 2.69±0.65 mg/mL, whereas in OC groups significantly higher values were found. Platelets number varied between individuals but was within normal range in all groups. Taking into account a decrease in protein C plasma level and an increase in fibrinogen concentration, the relationship between developmental diseases and coagulation disorders was revealed in dogs.

10

Complement activation contributes to ventilator-induced lung injury in rats

84%

Petersen B., Busch T., Gaertner J., Haitsma J. J., Krabbendam S., Ebsen M., Lachmann B., Kaisers U. X.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 6

11

Role of leptin during perinatal metabolic programming and obesity

84%

Djiane J., Attig L.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 1

The incidence of obesity is rapidly increasing all over the world in epidemic proportions.The epidemia now affects young children and accumulative evidences suggest that the origin of the disease may occur during foetal development and early life. This has introduced the concept of "developmental programming" supported by experimental studies in animal models and numerous epidemiological data. This concept supports the idea that nutritional and hormonal status during pregnancy and early life could interfere irreversibly on the development of the organs involved in the control of food intake and metabolism and particularly the hypothalamic structures responsible of the establishment of the ingestive behaviour and regulation of energy expenditure. The mechanisms responsible of this developmental programming remain poorly documented. However ,recent research indicate that the adipokine leptin plays a critical role in this programming.

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Blockade of nitric oxide formation impairs adrenergic-induced ACTH and corticosterone secretion

84%

Bugajski J., Gadek-Michalska A., Glod R., Borycz J., Bugajski A. J.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 2

13

Lipopolysaccharide-induced alterations in plasma glucose, free fatty acids and thyroid hormones in chickens are modified by exogenous reverse 3,3',5'-triiodothyronine [rT3]

84%

Bobek S., Niezgoda J., Sechman A.

Acta Agraria et Silvestria. Series Zootechnica

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2000

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tom 38

14

The effect of supplementing diet with L-carnitine on its levels in plasma and urine in individuals subjected to heavy work loads

84%

Raczynska B., Malczewska J., Raczynski G.

Polish Journal of Food and Nutrition Sciences

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2000

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tom 09/50

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nr 2

The aim of the study was (1) to determine changes in the total (TC), free (FC) and esterified (EC) L-carnitine (C) in plasma and urine of biathlonists ingesting various doses of C and (2) to find out whether the quantities of C ingested with the diet covered the metabolic needs for this compound. Male (n = 24) and female (n = 22) athletes, aged 17 years were divided in 4 groups given 0, 250, 500 and 750 mg-d"1 of C, respectively. The contents of energy, selected nutrients and of C were assessed by using the food composition tables. Relative C deficiency was determined from FC/TC and EC/FC ratios obtained from plasma measurements. The supplementation with C increased its concentration in plasma and excretion of FC and TC with urine, the levels of EC remaining relatively stable. Mean values of FC/TC and EC/FC ratios were within normal limits and did not depend on the degree of supplementation with C. However, relative C deficiency was observed in two men and five women and could have resulted from a too low C intake with diet or from an intensified catabolism of fatty acids. Supplementing athletes with small doses of C (250-500 mg·d-1) may thus be recommendable.

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Influence of Dermanyssus gallinae [poultry red mite] invasion on the plasma levels of corticosterone, catecholamines and proteins in layer hens

67%

Kowalski A., Sokol R.

Polish Journal of Veterinary Sciences

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2009

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tom 12

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nr 2

231-235

The results of studies conducted in 2006 revealed that mass red mite (Dermanyssus gallinae) invasions cause somatic stress which may be responsible for the pathophysiological mechanism of decreased egg production, lower humoral immunity and higher mortality in layer hens. The aim of this study was to validate the above research results, to investigate whether in addition to somatic stress, red mite invasions cause psychogenic stress due to the activation of the sympatho-ad- renomedullar system, and to determine the level of stress resulting from red mite infestations in comparison with a short, 1.5 h period of acute immobilisation stress. The study investigated 36 HY-Line Brown layer hens divided into three groups: a non-infested control group, an experimental group infested with red mites and a non-infested experimental group subjected to acute immobilisation stress for 1.5 h. Blood samples were taken from all hens for the determination of the levels of corticosterone, adrenaline, noradrenaline, albumin, and α-, ß- and y-globulins. The results validated the previous reports on the occurrence of somatic stress and on a significant decrease in y-globulin levels (p < 0.01) in the group of birds infested with red mites, in comparison with the control group. Adrenaline levels in infested hens were indicative of psychogenic stress. Based on a comparison of hormonal indicators in all hen groups, the level of somatic stress resulting from red mite infestation can be classified as moderate, while the level of psychogenic stress can be interpreted as high. A significant drop in y-globulin levels in the blood of birds infested with red mites also shows that the invasion induces chronic stress which lowers the humoral immunity of hens.

16

Expression and release of leptin and proinflammatory cytokines in patients with ulcerative colitis and infectious diarrhea

67%

Biesiada G., Czepiel J., Ptak-Belowska A., Targosz A., Krzysiek-Maczka G., Strzalka M., Konturek S. J., Brzozowski T., Mach T.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 5

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Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1

67%

Piotrowska K., Sluczanowska-Glabowska S., Kucia M., Bartke A., Laszczynska M., Ratajczak M. Z.

Folia Histochemica et Cytobiologica

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2015

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tom 53

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nr 3

18

Effects of time of day and the Wingate test on appetite perceptions, food intake and plasma levels of adipokines

67%

Bilski J., Jaworek J., Pokorski J., Nitecki J., Nitecka E., Pokorska J., Mazur-Bialy A., Szklarczyk J.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 5

19

Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome

67%

Zwirska-Korczala K., Konturek S. J., Sodowski M., Wylezol M., Kuka D., Sowa P., Adamczyk-Sowa M., Kukla M., Berdowska A., Rehfeld J. F., Bielanski W., Brzozowski T.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 1

13-35

20

The effect of short term treatment with probiotic VSL#3 on various clinical and biochemical parameters in patients with liver cirrhosis

67%

Marlicz W., Wunsch E., Mydlowska M., Milkiewicz M., Serwin K., Mularczyk M., Milkiewicz P., Raszeja-Wyszomirska J.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 6

Ograniczanie wyników

The renal actions of oxytocin in the conscious rat

On the metabolism of prostaglandin E1 administered intravenously to human volunteers

Age dependence of plasma endothelin levels in glaucoma patients

Plasma levels of Abeta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease

Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats

Elevated advanced oxidation protein products levels in patients with liver cirrhosis

Pain and mobility improvement and MDA plasma levels in degenerative osteoarthritis, low back pain, and rheumatoid arthritis after infrared A-irradiation

Pretreatment levels of vascular endothelial growth factor in plasma predict a complete remission rate and time to relapse or progression in patients with diffuse large B-cell lymphoma

Plasma level of protein C, fibrinogen concentration, and platelet number in dogs with Leg-Calve-Perthes disease and osteochondrosis. Preliminary studies

Complement activation contributes to ventilator-induced lung injury in rats

Role of leptin during perinatal metabolic programming and obesity

Blockade of nitric oxide formation impairs adrenergic-induced ACTH and corticosterone secretion

Lipopolysaccharide-induced alterations in plasma glucose, free fatty acids and thyroid hormones in chickens are modified by exogenous reverse 3,3',5'-triiodothyronine [rT3]

The effect of supplementing diet with L-carnitine on its levels in plasma and urine in individuals subjected to heavy work loads

Influence of Dermanyssus gallinae [poultry red mite] invasion on the plasma levels of corticosterone, catecholamines and proteins in layer hens

Expression and release of leptin and proinflammatory cytokines in patients with ulcerative colitis and infectious diarrhea

Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1