In the present study, the effect of stimulation of pregnant sows with isoprinozine or levamisole on parameters of unspecific immunity in piglets during first weeks of their life were examined. The investigations were carried out on three pregnant sows and their progeny. All the sows were clinically healthy and they were not vaccinated before the experiment. The first animal was given 10% solution of isoprinozine (Polfa Grodzisk), intramuscularly, three times with 7-day intervals at a dose of 75 mg/kg b.w. The second sow was injected with a water solution of levamisole, subcutaneously, at a dose of 2.5 mg/kg b. w. using identical time intervals. The third untreated sow served as a control. The first injections of the immunostimulators were performed three weeks before the parturition. Blood collected from piglets before administration of the first dose of colostrum, 48 h after giving them colostrum and then on the 7th, 14th, 21st , 28th, 35th and 42nd days of life was hemato- logically investigated. Following tests were performed on a whole blood or blood serum: reduction of NBT, phagocytic index, test of intracellular killing of neutrophils, total protein content and y-globulin complex, bacteriolytic activity of lysozyme, level of immunoglobulin of the IgG class. It was found that immunostimulation of the pregnant sows with isoprinozine or levamisole activated unspecific protective cellular immune mechanisms of newborn piglets. This activation was manifested by an increased activity of polymorphonuclear reduction cells (PMN) to NBT, the growth of phagocytic index and significantly higher bactericidal activity of neutrophils. Moreover, in the progeny of the sow treated with levamisole, the activity of serum lysozyme was significantly augmented.
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