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1

Dose-dependent effects of pyrazinamide on liver cytochrome P-450 2E1

100%
Kovalenko V. M., Bondarenko L. B., Matvienko A. V., Shayakhmetova G. M., Byshovets T. F., Voloshina E. S., Voronina A. K., Saprykina N. A.
Acta Toxicologica
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2007
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tom 15
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nr 2
149-156
2

Selected markers of oxidative stress in overweight and obese women - a link between obesity and atherosclerosis

100%
Karolkiewicz J., Karolkiewicz J., Pilaczynska-Szczesniak L., Deskur-Smielecka E., Nowak A., Michalak E., Stankiewicz K., Chmurska M.
Polish Journal of Environmental Studies
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2004
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tom 13
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nr Suppl.2, Part 1
The results of recent studies indicate that obesity is associated with an increase in peroxidation processes. The aim of the present study was to assess the degree of oxidative stress in obese women and to evaluate the relationship between selected markers of oxidative stress and body mass index. Study population consisted of 43 women aged 21 to 66. Subjects were divided into two groups according to their body mass index (BMI): Overweight group (BMI < 30 kg/m2) and Obese group (BMI > 30 kg/m2). Venous blood samples were taken from each subject after an overnight fast and following parameters were assessed: plasma total antioxidant status (TAS), plasma concentrations of thiobarbituric acid reactive substances (TBARS), serum levels of antibodies against oxidized low density lipoproteins (oLAB), serum lipid profiles, serum glucose and insulin concentrations. Additionally, serum low density lipoprotein (LDL) cholesterol and insulin resistance indices were calculated. Serum triglyceride concentrations, insulin levels and insulin resistance indices were significantly higher in obese women in comparison with overweight ones. No significant differences in TBARS concentrations, TAS and oLAB levels were found between the two study groups. However, oLAB titres in Obese group were above the upper limit of the reference range for healthy adults. In both study groups significant correlations (p <0.01) between BMI and levels of triglycerides, insulin concentrations and insulin resistance indices were observed. Additionally, positive correlations (p < 0.05) between BMI and LDL-cholesterol and diastolic blood pressure as well as negative correlations (p < 0.05) between HDL-cholesterol and diastolic blood pressure were found in Obese group. In the overweight women, there were positive correlations between oLAB levels and triglyceride and insulin concentrations, between oLAB titres and insulin resistance indices and between oLAB levels and systolic and diastolic blood pressure (p < 0.01 for all correlations). There was also a negative correlation between oLAB titres and TAS (p < 0.05). The results of the present study confirm that obesity is associated with oxidative stress. Oxidative stress may be the link between obesity and atherosclerosis.
3

Oxidative-antioxidative status of blood plasma in bitches with mammary gland tumours

100%
Szczubial M., Kankofer M., Albera E., Lopuszynski W., Dabrowski R.
Bulletin of the Veterinary Institute in Puławy
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2008
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tom 52
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nr 2
The aim of the study was the estimation of oxidative/antioxidative status of bitches with mammary gland tumours by the determination of lipid peroxidation intensity, concentration of glutathione and β-carotene as well as total antioxidant capacity (TAC) in blood plasma. The experiment was carried out on 18 bitches with spontaneously occurring mammary gland tumours (12 with malignant tumours and 6 with benign tumours) and 6 clinically healthy controls. The intensity of lipid peroxidation did not differ significantly among the examined groups of animals. The concentration of glutathione was higher in both neoplasm groups than in healthy bitches, but the differences were not significant. The concentration of β-carotene in plasma was similar in cases of malignant and benign tumours, but was significantly lower (P<0.05) than in healthy controls. TAC of plasma was lower in bitches with tumours than in healthy animals. Significant difference was noticed between malignant tumours and controls (P<0.01). In conclusion, the alterations in antioxidative status occur in bitches with mammary gland tumours, suggests the presence of general antioxidative stress. A necessity of more frequent sample collection for the detection of dynamic changes in peroxidation process revealing the intensity of oxidative stress in bitches suffering from mammary gland tumours should be considered.
4

The influence of peroxidation processes on gastric mucosa protective system in rat

100%
Lutnicki K., Szpringer E.
Journal of Physiology and Pharmacology. Supplement
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2001
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tom 52
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nr 2
5

The effect of feeding method on body weight gains, concentrations of selected components in the blood, and peroxidation processes of carp, Cyprinus carpio L.

80%
Stepanowska K., Sawicka A.
Acta Ichthyologica et Piscatoria
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2006
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tom 36
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nr 1
Background. Fish are the principal source of n-3 and n-6 fatty acids for humans. Traditionally, these fatty acids have been supplied in the form of captured marine and freshwater fishes. Recently, freshwater cultured species have been increasing their share in the fish volume on the market. Therefore it is crucial for fish farmers to rear fish under proper condition and with proper feeding in order to receive good quality fish flesh at harvest. The presently reported study was aimed at determining the effect of diet with the increased level of lipids or carbohydrates on selected blood indices, reduced glutathione content, lipid peroxidation products concentration in the liver, and body weight gains in carp fingerlings reared in post-cooling waters. Materials and Methods. The experiment was carried out in spring (2004) on 300 carp divided into two feeding groups. Group I was fed high-fat feed, whereas group II high-carbohydrate feed. After 7 weeks, fish blood and livers were collected for further analyses. Results. Significantly higher body weight gains were found in the fish fed high-fat feed as well as significant increase of haemoglobin (Hb) concentration in the blood of both feeding groups, which was accompanied by the increase of haematocrit (Ht) index. Furthermore, an increase in the concentration of lipid peroxidation products was observed as well as significantly lower content of reduced glutathione (GSH) in the livers of fish examined. Conclusion. The observed MDA values and reduced glutathione (GSH) concentration in the fish liver may indicate enhanced peroxidation processes in the organisms of the fish from both experimental groups, caused by their intensive feeding with extruded feeds. The peroxidation processes were more intensive in fish fed high-fat feeds.
6
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Effect of diet on lipid peroxidation in liver microsomes, intestine brush border membrane and in blood serum of rats

80%
Tokarz A., Oledzka R., Sulinski A.
Polish Journal of Food and Nutrition Sciences
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1992
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tom 01
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nr 1
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