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1

Peptydy przeciwdrobnoustrojowe - rys historyczny i mechanizm ich działania

100%
Bagnicka E., Jozwik A., Strzalkowska N., Krzyzewski J., Zwierzchowski L.
Medycyna Weterynaryjna
|
2011
|
tom 67
|
nr 07
By now, over 800 different antimicrobial peptides have been identified in fauna and flora. Antimicrobial peptides (AMPs) are an important part of the innate immunity of all living organisms. The first animal AMP was found in 1962 by Kiss and Michl in the venomous skin secretion of the orange speckled frog Bombina variegata. Most known AMPs are multifunctional as effectors of innate immunity and have direct antimicrobial activity against various bacteria, enveloped viruses, and fungi. Most of them share a common mechanism of antimicrobial action: permeabilization of the cell membrane of the pathogen. There is a real chance to use these peptides for developing a new generation of medicines. The present review outlines the history of studies on antimicrobial peptides and the current state of knowledge about their activity.
2

Aktywność przeciwdrobnoustrojowa lipopeptydów

86%
Czechowicz P., Nowicka J.
Postępy Mikrobiologii
|
2018
|
tom 57
|
nr 3
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Patofizjologia posocznicy. Część I. Rola peptydów przeciwdrobnoustrojowych jako ważnego elementu odporności wrodzonej

86%
Kalwas-Sliwinska M.
Życie Weterynaryjne
|
2014
|
tom 89
|
nr 10
4

Peptydy przeciwdrobnoustrojowe w zwalczaniu patogenów opornych na powszechnie stosowane antybiotyki

72%
Bagnicka E., Strzalkowska N., Jozwik A., Horbanczuk J. O., Krzyzewski J., Zwierzchowski L.
Medycyna Weterynaryjna
|
2011
|
tom 67
|
nr 08
The common abuse of antibiotics during the twentieth century caused the development of many multiresistant pathogens to classic antibiotics. To find new strategies to fight against resistant pathogens is the challenge of the twenty-first century. Since they seem to be natural antibiotics, peptides produced by bacteria, insects, amphibians and mammals with cytotoxic activities against bacteria, mycobacteria, fungi and enveloped viruses are one of the groups with prospects for use in therapy against pathogens. Such peptides protect the cells which produce them. Cationic peptides are a huge group of antimicrobial peptides, consisting of a number of families, e.g. defensins and cathelicidins. Their expression was initially found in phagocyte cells, like macrophages and neutrophiles as well as in epithelial cells. The aim of this study was to present a review of antimicrobial peptides identified in humans and in economically important farm animals and to discuss the possibilities of using them in therapy and prophylaxis.
5

Technologia S-I-S SKIN INNOVATIVE Science - duży krok naprzód w dermatologii weterynaryjnej

72%
Magazyn Weterynaryjny
|
2016
|
tom 25
|
nr 11
6
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Neutrofilowe obronne białka i peptydy w leczeniu zwierząt i ludzi

72%
Wessely-Szponder J., Bobowiec R.
Życie Weterynaryjne
|
2011
|
tom 86
|
nr 04
7

Peptydy przeciwdrobnoustrojowe - nowe możliwości zwalczania infekcji u ludzi i zwierząt

44%
Mirski T., Gryko R., Bartoszcze M., Bielawska-Drozd A., Tyszkiewicz W.
Medycyna Weterynaryjna
|
2011
|
tom 67
|
nr 08
Antimicrobial peptides (AMPs), also called peptide antibiotics, have been discovered in the early 1980s in frogs They were antimicrobial substances called magainins. AMPs are among the oldest defense mechanisms in plants, humans and animals. The major peptides include i.a. defensins, cathelicidins and protegrins. The mechanisms of action of antimicrobial peptides rely on the permeabilization of the microbial membrane, destabilization of the lipid bilayer structure, creation of micelles or channels within the membrane, binding lipopolysaccharide (LPS), preventing DNA replication, inhibiting protein expression, releasing ATP, as well as binding free iron and removing it from the microbial growth environment. At present, intensive research is being conducted on the use of AMPs in human and veterinary medicine, including treatment of infections such as acne, skin infections, sepsis, and bacterial infections of the diabetic foot. Among others, the following preparations are being tested: Ambicin, for the treatment of infections caused by Mycobacterium, and Iseganan, protegrin for the treatment of mouth inflammation, CF and chronic lung infections. P. aeruginosa-infected animals treated with the D2A21 preparation showed 100% survival. Some of the AMPs show biocidal activity against Bacillus anthracis. Defensins isolated from the mucus and tissues of many fish species have the ability to protect fish from infections by Aeromonas hydrophila, Pseudomonas fluorescens, and Vibrio anguillarum. Beneficial effects of using defensins in the treatment of Borrelia burgdorferi infections in dogs have been described. Synthetic peptides are used for the production of a vaccine against parvovirosis. Peptides obtained from lactic acid bacteria (LAB) reduce the contamination and increase the stability of food products. AMPs are also useful for decontaminating the environment and medical equipment, as well as for sterilizing catheters. They have also been used to develop biocidal self-disinfecting surfaces (BSOs). Moreover, AMPs can be used in hospital hygiene and veterinary medicine, e.g., for the treatment of protective clothing, wipes, filters, ventilation, etc.
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