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Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats

100%

Czechowska G., Celinski K., Korolczuk A., Wojcicka G., Dudka J., Bojarska A., Reiter R. J.

Journal of Physiology and Pharmacology

2015

tom 66

nr 4

Anion transport across the red blood cell membrane in the presence of malathion and parathion and their main metabolites

100%

Blasiak J.

Cellular and Molecular Biology Letters

1996

tom 01

nr 4

The effect of organophosphorus insecticides malathion and parathion as well as their main metabolites malaoxon and paraoxon on chloride (36Cl-) and sulfate (35SO42-) equilibrium exchange in pig erythrocytes was investigated using an isotope labelling technique. Efflux of both radioactive isotopes vs. time followed a single exponential. Parathion and paraoxon inhibited the chloride equilibrium exchange in intact ceils in a dose- and time-dependent manner. There was no difference between effects evoked by these two compounds. Neither malathion nor malaoxon affected the chloride transport. Parathion and paraoxon inhibited sulfate efflux from resealed ghosts. The effect was also dose- and time-dependent. Again, there was no difference between action of the agents. No effect of malathion and malaoxon on sulfate efflux was observed. Dixon analysis revealed noncompetitive character of the inhibition of the exchange of both anions with the apparent Ki, values 68 and 73 µM for parathion and paraoxon, respectively in the case of chloride transport; for sulfate exchange these values were 341 and 340 µM, respectively. It was suggested that structural similarity between parent agents and their metabolites is responsible for the identity of their effects. Parathion and paraoxon could inhibit the anion exchange indirectly by changing the fluidity of the erythrocyte membrane or directly by binding to the Band 3 protein and evoking conformational changes leading to the inhibition of the anion transport. The insecticides, due to their ability to phosphorylate, could also disturb some regulation processes in the Band 3 protein.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Journal of Physiology and Pharmacology

1 Blasiak J.

1 Bojarska A.

1 Celinski K.

1 Czechowska G.

1 Dudka J.

1 Korolczuk A.

1 Reiter R. J.

1 Wojcicka G.

1 2015

1 1996

Wyniki wyszukiwania

Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats

Anion transport across the red blood cell membrane in the presence of malathion and parathion and their main metabolites