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1

Veins with saccular dilatations in gastric mucosa of the rat

100%
Moskalewski S., Biernacka-Wawrzonek D., Klimkiewicz J., Zdun R.
Folia Morphologica
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1999
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tom 58
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nr 3
It is well known that blood from the gastric mucosa of the rat is drained by collecting veins (venules). The aim of this study was to describe hitherto unrecognized saccular dilatations connected with these vessels. Rats received atropine or papaverine l h before ligation of the portal vein, Stomachs fixed in formaldehyde were prepared in toto after clearing in methyl salicylate or processed by standard histological technique. A single stomach contained about 1000 connecting veins localized exclusively in the oxyntic mucosa. After administration of relaxing agents and portal vein ligation the collecting veins were enlarged and in 80 percent of them one to three sacculi filled with blood could be seen. Histological observations shown that collecting veins empty into veins running between lamina muscularis and lamina propria mucosae. Sacculi were partially separated from the lumen of the collecting vein by a tissue band. In view of the relaxing effect evoked by atropine the veins and their sacculi appear to be under vagal control. Conceivably, their alternate expansion and collapse could facilitate movement of glandular content to the surface of the stomach and/or movement of interstitial fluid between cells.
2
Content available remote

Vasodilatory effect and endothelial integrity in papaverine- and milrinone-treated human radial arteries

84%
Rudzinski P., Wegrzyn P., Lis G. J., Piatek J., Konstanty-Kalandyk J., Nosalski R., Mikolajczyk T., Jasinska M., Pyka-Fosciak G., Guzik T., Litwin J. A., Korbut R., Sadowski J.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 1
3
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Studies on gastroprotection induced by capsaicin and papaverine

84%
Brzozowski T., Drozdowicz D., Majka J., Konturek S. J.
Journal of Physiology and Pharmacology
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1992
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tom 43
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nr 4
Capsaicin and papaverine are potent vasorelaxants with strong gastroprotective activity against damage induced by absolute ethanol. This protection was originally attributed to the increase in gastric mucosal blood flow (GBF) but the possibility that NO mediates the protective and hyperemic effects of capsaicin and papaverine has been little studied. Using N-nitro-L-arginine (L-NNA), a selective blocker of NO synthase, and L-arginine as a substrate for NO, we investigated the role of NO in protective action of capsaicin and papaverine against ethanol-induced gastric damage and in GBF. Pretreatment with capsaicin (0.1-0.5mg/kg i. g.) or papaverine (0.1-2mg/kg i.g.) reduced dose-dependently the area of ethanol- induced lesions, the LD50 being 0.3 and 1 mg/kg, respectively. This protection was accompanied by a gradual increase in the GBF. Intravenous (i. v.) injection of L-NNA (1.2-5 mg/kg), which by itself caused only a small increase in ethanol lesions, reversed dose-dependently the protective and hyperemic effects of capsaicin and papaverine against ethanol-induced damage and attenuated the increase in GBF induced by each of these agents alone. This deleterious effect of L-NNA on the gastric mucosa and the GBF was fully antagonized by L-arginine (200 mg/kg i. v.) but not by D-arginine. L-arginine partly restored the decrease in GBF induced by L-NNA. Pretreatment with indomethacin (5 mg/kg i.p.), which suppressed the generation of PG by 85%, slightly enhaced the mucosal lesions induced by ethanol but failed to affect the fall in GBF induced by this irritant. Gastroprotective and hyperemic effects of capsaicin and papaverine were partly reversed by indomethacin suggesting that endogenous PG are also implicated in these effects. Addition of L-NNA to indomethacin completely eliminated both the protective and hyperemic effects of capsaicin and papaverine. We conclude that both NO and PG contribute to the gastroprotective and hyperemic effects of capsaicin and papaverine on the gastric mucosa.
4

Papaverine should not be used as an indicator for controlling the ability of the gastrointestinal tract muscle to relax in vitro

67%
Chlopecka M., Dziekan N., Bakala A., Wiechetek M., Mendel M.
Medycyna Weterynaryjna
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2007
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tom 63
|
nr 11 Supl.
1437-1439
The aim of this research was to study the possibilities of using papaverine as a reference substance to control the ability of isolated gastrointestinal (GI) tract strips to relax. The effects of papaverine hydrochloride (0.001-100 µM) dissolved in distilled water, or in DMSO (0.5%), on the mechanical activity of isolated rat GI strips (stomach fundus and corpus, duodenum and jejunum) were studied. The obtained results show that papaverine provoked various responses of the examined muscle strips dependent on the part of GI tract and papaverine solvents used (water or DMSO). Papaverine applied as water solution caused muscle relaxation of all investigated gastrointestinal strips: the lowest effective (induced relaxation) concentration of papaverine was 10 µM for gastric corpus, jejunum and duodenum and 100 µM for gastric fundus. However, there was no dependence between the concentration of papaverine and the degree of muscle relaxation of the studied GI strips. Moreover, in case of gastric fundus strips, papaverine applied as 0.5% DMSO solution provoked different muscle responses: in the presence of 0.1 and 1 µM papaverine contraction occurred; administering papaverine at higher concentrations (10 and 100 µM) resulted in relaxation. The obtained results clearly indicate that papaverine does not fulfil the criteria set for the reference substance and should not be used as an indicator for controlling of gastrointestinal tract muscle relaxation in vitro.
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