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1

Oxidative metabolism after anaerobiosis in barley [Hordeum vulgare L.] seedlings

100%
Szal B., Rychter A. M.
Polish Journal of Natural Sciences. Supplement
|
2003
|
tom 01
2

Effect of beta-1,3-1,6-D-glucan on the phagocytic activity and oxidative metabolism of pripheral blood granulocytes and monocytes in rats

86%
Wojcik R., Janowska E., Malaczewska J., Siwicki A. K.
Bulletin of the Veterinary Institute in Puławy
|
2009
|
tom 53
|
nr 2
241-246
The experiment was performed on 20 adult Wistar rats aged 12 weeks, divided into two equal groups (control and experimental), each comprised of five males and five females. From the first day of the experiment, the experimental group rats were fed Murigran feed supplemented with ß-l,3/l,6-D-glucan at a dosage of 12-19 mg/rat/d, subject to body weight, while the control- group was administered the same feed without any additives. At the beginning of the experiment and then after 14 days, arterial blood samples were collected from the rats and diluted with heparin to measure and compare the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes by flow cytometry. Statistically higher levels of the activity were observed in the group of rats administered glucan than in controls, expressed in terms of the percentage of phagocytic cells as well as average fluorescence intensity. ß-l,3/l,6-D-glucan also had a positive effect on the oxidative metabolism of both granulocytes and monocytes after stimulation with E. coli, and on the oxidative metabolism of granulocytes after stimulation with PMA.
3
Content available remote

Oxygen uptake kinetics: Why are they so slow? And what do they tell us?

72%
Grassi B.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 10
53-65
O2 kinetics and O2 deficit are important determinants of exercise tolerance. In "normal" conditions convective and diffusive O2 delivery to skeletal muscle fibers do not represent important determinants of O2 kinetics, whose limiting factors seem mainly located within muscle fibers. Whereas a limiting role by PDH has not been confirmed, the role of inhibition of mitochondrial respiration by NO needs further investigations. Important determinants of skeletal muscle O2 kinetics likely reside in the interplay between bioenergetic mechanisms at exercise onset. By acting as high-capacitance energy buffers, PCr hydrolysis and anaerobic glycolysis would delay or attenuate the increase in [ADP] within muscle fibers following rapid increases in ATP demand, preventing a more rapid activation of oxidative phosphorylation. The different "localization" of the main limiting factors for O2 kinetics and O2max offers the opportunity to perform a functional evaluation of oxidative metabolism at two different levels of the pathway for O2, from ambient air to mitochondria. WhereasO2max is mainly limited by the capacity of the cardiovascular system to deliver O2 to exercising muscles, by analysis of O2 kinetics the functional evaluation is mainly related to skeletal muscle. In pathological conditions the situation may be less clear, and warrants further investigations.
4

Effects of Aronia melanocarpa polyphenols on oxidative metabolism and apoptosis of neutrophils from obese and non-obese individuals

72%
Zielinska-Przyjemska M., Olejnik A., Dobrowolska-Zachwieja A., Grajek W.
Acta Scientiarum Polonorum. Technologia Alimentaria
|
2007
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tom 06
|
nr 3
Reactive oxygen species are postulated to be involved in systemic inflammation and oxidative stress in patients with obesity. Activated polymorphonuclear neutrophils (PMNs) generate extremely high amounts of reactive oxygen species, but these are normally targeted at pathogens inside intracellular phagosomes. The same beneficial antimicrobial functions, if not controlled, contribute to the tissue damaging effects of inflammatory reactions. The evidence from conventional epidemiology strongly implies fruits and vegetables in protection against oxidative stress. In our study, the in vitro effects of Aronia melanocarpa juice on oxidative metabolism and apoptosis of neutrophils from obese and non-obese individuals has been investigated. We tested 15 obese patients (aged 45 ±9 years, women, BMI = 34 ±4.9 kg/m2). Nine healthy subjects (BMI = 22.2 ±1.6 kg/m2) were enrolled as controls. Neutrophils were isolated and oxidant production, in response to phorbol 12-myristate 13-acetate, was characterized by using luminol dependent chemiluminescence (CL) and flow cytometric dichlorofluorescin oxidation assay. Caspase-3 activity, a marker of apoptosis execution, in human neutrophils, measured by a cleavage of the fluorogenic substrate Ac-DEVD-AMC. Additional experiments to assess the direct toxic effect of the aronia polyphenols were also carried out. Neutrophils from obese individuals had a significantly higher H2O2 production and CL response compared to controls (p < 0.05). The oxidative metabolism of PMNs was decreased by aronia juice treatment in both of groups, obese and non-obese individuals. The caspase-3 activity depended on the time of aronia juice treatment and was markedly increased in phorboltreated cells incubated with polyphenols for 24 hours. This natural product exert beneficial effects in cells and may, therefore, be useful in the treatment of obesity disorders
5

The flavonoids, quercetin and isorhamnetin 3-O-acylglucosides diminish neutrophil oxidative metabolism and lipid peroxidation

72%
Zielinska M., Kostrzewa A., Ignatowicz E., Budzianowski J.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 1
Two natural flavonoids, quercetin and isorhamnetin 3-O-acylglucosides, were examined for their inhibitory influence on the in vitro production and release of reactive oxygen spe­cies in polymorphonuclear neutrophils (PMNs). The generation of superoxide radical, hy­drogen peroxide and hypochlorous acid were measured by, respectively, cytochrome c re­duction, dichlorofluorescin oxidation and taurine chlorination. Membrane lipid oxidation was studied by the thiobarbituric acid method in mouse spleen microsomes. The addition of flavonoids at the concentration range 1-100 uM inhibited PMNs oxidative metabolism and lipid peroxidation in a dose-dependent manner. The results suggest that these flavonoids suppress the oxidative burst of PMNs and protect membranes against lipid peroxidation.
6
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Content available

Effect of Biolex Beta-HP on phagocytic activity and oxidative metabolism of peripherial blood granulocytes and monocytes in rats intoxicated by cyclophosphamide

58%
Wojcik R.
Polish Journal of Veterinary Sciences
|
2010
|
tom 13
|
nr 1
181-188
The objective of this study was to determine the effect of ß-l,3/l,6-D-glucan (Biolex-Beta HP) on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats intoxicated by cyclophosphamide. The experimental material comprised 40 adult Wistar rats aged 14 weeks, divided into two equal groups, a control group and an experimental group, each of 20 adult rats, including 10 males and 10 females. In the course of 3 successive days, 20 rats from the experimental group were administered cyclophosphamide intramuscularly at a dose of 50 mg/kg body weight/day. On the 8th day of the experiment, 10 control group (K) rats and 10 experimental group (C) rats were sacrificed. Arterial blood samples were collected and diluted with heparin to determine and compare the phagocytic activity (Phatogest) and oxidative metabolism (Bursttest) of peripheral blood granulocytes and monocytes by flow cytometry. Starting on the 8lh day of the experiment, the feed of the remaining 10 rats from the experimental group (C+G) and 10 rats from the control group (G) was supplemented with Biolex-Beta HP at a dose of 50 mg/kg body weight/day for 14 consecutive days. On day 22, arterial blood samples were collected from all (C+G) and (C) group rats, diluted with heparin to determine and compare the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes by flow cytometry. The results showed that Biolex-Beta HP modulated the phagocytic activity and oxidative metabolism of blood neutrophils and monocytes suppressed by cyclophosphamide in rats. The immunorestoring activity of Biolex-Beta HP was observed in this study.
7
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Content available

NADPH oxidase C is not the main source of ROS under arsenic toxicity but regulates antioxidants and metal transporters

58%
Gupta D., Inouhe M., Rodriguez-Serrano M., Romero-Puertas M., Sandalio L.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
|
tom 94
|
nr 2
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Physiologic, metabolic and mediator responses in posttrauma ards and sepsis; is oxygen debt a critical initiating factor?

58%
Siegel J. H.
Journal of Physiology and Pharmacology
|
1997
|
tom 48
|
nr 4
9

The susceptibility of the large pine weevil [Hylobius abietis L.] to insecticides and the role of the oxidative metabolism in the developing of the pest resistance to DDT and pyrethroids

58%
Dobrowolski M.
Folia Forestalia Polonica. Series A . Forestry
|
2000
|
tom 42
10
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Superoxide dismutase and glutathione peroxidase activity in porcine follicular fluid i relation to follicle size, birth status of gilts, ovarian location and year season

51%
Lasota B., Blaszczyk B., Stankiewicz T., Udala J., Szewczyk M., Matusiak-Bielska D.
Acta Scientiarum Polonorum. Zootechnica
|
2009
|
tom 08
|
nr 1-2
19-29
11
Content available remote

Role of leptin, ghrelin, angiotensin II and orexins in 3T3 L1 preadipocyte cells proliferation and oxidative metabolism

51%
Zwirska-Korczala K., Adamczyk-Sowa M., Sowa P., Pilc K., Suchanek R., Pierzchala K., Namyslowski G., Misiolek M., Sadowski K., Kato I., Kuwahara A., Zabielski R.
Journal of Physiology and Pharmacology. Supplement
|
2007
|
tom 58
|
nr 1
53-64
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