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1

Use of oromucosally administered interferon-alpha in the prevention and treatment of animal diseases

100%
Dec M., Puchalski A.
Polish Journal of Veterinary Sciences
|
2008
|
tom 11
|
nr 2
175-186
Interferon-a (IFN-a) is well known as a clinically effective antiviral and antineoplastic therapeutic agent. It has also been shown to have immunoregulatory properties. IFN-a stimulates a cell-mediated innate immune response and then participates in the transition of the initial host innate response to an effective adaptive immune response. IFN-a is produced in small quantities in nasal secretions during viral infections, prompting many authors to suggest that low-dose oromucosal administration of IFN-a effectively mimics nature. Moreover, the injectable high-dose interferon therapy currently approved for various human disorders causes numerous side effects. By contrast, oromucosal administration of IFN-a is not associated with toxic effects. Another distinct advantage is ease of administration: the IFN can be dissolved in drinking water or administered by nebulization to the oral or nasal cavity. This review describes the current state of knowledge concerning orally administered IFN-a, of both human and animal origin, as a prophylactic or therapeutic agent in veterinary medicine. We present the effects of IFN-a in such animals as cattle, pigs, horses, cats, dogs and chickens, and attempt to explain its mechanism of action following oromucosal administration. It is hoped that this review of the medical literature on the use of IFN-a in animals will give practitioners a better understanding of the challenges and benefits of using this interesting cytokine in clinical practice.
2

Effect of oral aspartame administration on the excretion and distribution of calcium in rat tissue

100%
Kovatsi L., Tsouggas M.
Journal of Elementology
|
2005
|
tom 10
|
nr 4 Suppl.1
50-51
3
Content available remote

Effects of cilostazol on the pharmacokinetics of carvedilol after oral and intravenous administration in rats

84%
Lim T. H., Cho Y. A., Choi D. H.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 4
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Comparative toxicological effects of orally and intraperitoneally administered aqueous extracts of Abrus precatorius leaf in Mus musculus

84%
Saganuwan S., Onyeyili P. A., Suleiman A. O.
Herba Polonica
|
2011
|
tom 57
|
nr 3
Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins, tannins, reducing sugar, total glycoside and saponin glycosides in high concentration. Proximate analysis revealed the presence of moisture (6.18%), dry matter (93.90%), crude protein (12.06%), crude fibre (15.33%), nitrogen free extract (34.12%), ash (12.28%) and oil (19.21%). Comparative toxicological assessment of orally and intraperitoneally administered aqueous extracts of Abrus precatorius leaf was carried out in Swiss albino mice. Median lethal doses (LD50) of orally and intraperitoneally administered aqueous extracts of Abrus precatorius leaf were estimated at dose levels of 2558.9 mg/kg and 638 mg/kg body weight, respectively. Intraperitoneal 10 mg/kg body weight of the extract caused increased packed cell volume, neutropenia and decreased aspartate aminotransferase. However, 50 mg/kg oral dose caused increased packed cell volume, neutropenia, decreased alkaline phosphatase and hypochloraemia, whereas oral aqueous dose of 250 mg/kg of body weight caused body weight gain, neutropenia, decreased asparatate aminotransferase and alanineaminotransferase. All the test doses caused lymphocytosis and hypercreatinaemia, hence aqueous extract of Abrus precatorius leaf is toxic at dose levels of 10, 50 and 250 mg/kg body weight.
5

Influence of Bi 58 Nowy (38% dimethoate) on pyrantel embonate concentration in the liver of rats

84%
Barski D., Zasadowski A.
Polish Journal of Veterinary Sciences
|
2009
|
tom 12
|
nr 4
The aim of the study was to determine the concentration of pyrantel residues in the liver of rats in different time points after oral administration of pyrantel embonate as well as combined administration of the Bi 58 Nowy preparation (38% of dimethoate) and pyrantel embonate. The experiment was conducted in two stages involving different doses of compounds and modes of exposure. At the first stage, the animals were administered pyrantel embonate with a stomach tube at a dose of 1000 mg/kg b.w. twice in a two-week interval, i.e. on day 14 and 28, and the Bi 58 Nowy preparation with drinking water at a dose of 15.48 mg/kg b.w. for 28 days. At the second stage, the rats received pyrantel embonate at a dose of 400 mg/kg b.w. with a stomach tube for 3 consecutive days, whereas the Bi 58 Nowy preparation was administered at a dose of 38.7 mg/kg b.w. also with a stomach tube for 5 consecutive days. In the rats doubly administered with pyrantel embonate, its residues were present until day 14, whereas when the drug was administered for 3 consecutive days they were present until day 7 of the experiment. The maximum concentration of pyrantel embonate was found in the liver after the 3rd hour, whereas a considerable decrease occurred between the 3rd and the 12th hour. The combined administration of pyrantel embonate and the Bi 58 Nowy preparation caused a significant decrease in the concentration of pyrantel residues in the liver 3 and 6 hours after exposure, as compared to the rats receiving the drug alone.
6

Pharmacokinetics of tylosin in broiler chickens

84%
Kowalski C., Rolinski Z., Zan R., Wawron W.
Polish Journal of Veterinary Sciences
|
2002
|
tom 05
|
nr 3
7

Evaluation of the bioequivalence of two erythromycin thiocyanate formulations after oral administration to broiler chickens

84%
Kowalski C. J., Pomorska-Mol M.
Bulletin of the Veterinary Institute in Puławy
|
2009
|
tom 53
|
nr 2
247-250
Twenty-one eight-week-old healthy broiler chickens of both sexes were used in the experiment. The birds were randomly allotted to three groups: two experimental (A and B) and one control. The chickens from group A received erythromycin in the form of granulate (Erytrowet® granulat), while the chickens from group B received erythromycin as a powder (Erytrowet®). Both formulations were administrated orally at a single dose of 25 mg/kg b.w. Blood samples were collected at 0.5, 1, 2, 2.5, 3, 4, 6, 8 and 12 h after administration of the drugs. Erythromycin concentrations were determined by the HPLC method. Comparison of the plasma pharmacokinetic profiles of both products indicated that there were no differences in the basic pharmacokinetic parameters between both formulations. The results indicate that the formulations used in this study are bioequivalent.
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effectiveness assessment of oral administration of bentonite or alginate in reducing the transfer of radiostrontium to tissues and organs of rats

84%
Rachubik J.
Bulletin of the Veterinary Institute in Puławy
|
2000
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tom 44
|
nr 2
Decontamination efficiency of bentonite from Polish geological deposits and alginate in reducing the radiostrontium transfer to tissues and organs of rats was examined. The ⁹⁰Sr activity concentration in bones of the rats after the bentonite treatment was similar to that of the control animals. In contrast, in bones of the alginate treated rats the radioactivity was markedly higher than that of the control group. In soft tissues and organs the higher decontamination efficiency was found for alginate (up to 97.1 % ). However, bentonite from Polish geological deposits was also fairly efficient in reducing the radiostrontium transfer to rat organisms. Moreover, this decontamination agent is frequently administered and effective in cases of radiocaesium contamination. lt seems that bentonite could be an effective agent used in the case of the environmental radioactive pollution, when radionuclides of strontium and caesium are released simultaneously.
9

Woda pitna nosnikiem szczepionek dla drobiu

67%
Wezyk S., Cholocinska A., Cywa-Benko K.
Biuletyn Informacyjny. Instytut Zootechniki
|
1997
|
tom 35
|
nr 2
17-23
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