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Immunotherapy in Gram-negative bacterial infections

100%

Lugowski C.

Acta Biochimica Polonica

1995

tom 42

nr 1

Endotoxins are responsible for initiation of septic shock which increases the number of fatalities in Gram-negative bacteremia among hospital patients. The morality from septic shock is still high despite recent developments in antibiotic therapy because antibiotics are unable to decrease the level of free lipopolysaccharide in the blood stream. Another approach to the treatment and prevention of septicaemia involves stimulation of an immune response against LPS. It was found that immunization with the core structures of endotoxin conjugated with proteins protected animals against infections and endotoxic shock. Anticonjugate sera are of great interest because they are directed against conserved parts of LPS and therefore could have cross-reactive and cross-protective properties with respect to many Gram-negative rods.

Structural and serological characterization of Hafnia alvei lipopolysaccharide core region

100%

Lugowski C., Niedziela T., Jachymek W., Klonowska A., Czarny A., Rowinski S., Petersson C., Kenne L.

Acta Biochimica Polonica

1995

tom 42

nr 1

The structures and serological activities of core oligosaccharide of Hafnia alvei strains have been investigated. Methylation analysis, NMR spectroscopy and various specific degradation procedures were the principal methods used. It is concluded that, core hexasaccharides are identical in the lipopolysaccharides tested and are built of two glucose, three heptose and one 2-keto-3-deoxyoctulosonic acid residues. The antiserum raised against the ATCC13337oligosaccharide core-tetanus toxoid conjugate cross-reacted strongly with all lipopolysaccharides used as antigens in ELISA test, suggesting that this core region is the common structure in the Hafnia genus.

Ograniczanie wyników

2 Acta Biochimica Polonica

2 Lugowski C.

1 Czarny A.

1 Jachymek W.

1 Kenne L.

1 Klonowska A.

1 Niedziela T.

1 Petersson C.

1 Rowinski S.

2 1995

Wyniki wyszukiwania

Immunotherapy in Gram-negative bacterial infections

Structural and serological characterization of Hafnia alvei lipopolysaccharide core region