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Effect of long-term cadmium intoxication on selected biochemical parameters in experimental animals

100%

Kowalczyk E., Jankowski A., Niedworok J., Smigielski J., Tyslerowicz P.

Polish Journal of Environmental Studies

2002

tom 11

nr 5

Cadmium (Cd) is a dangerous occupational and environmental toxin. Exceeding its permissible weekly uptake in meals is a disturbing phenomenon. The aim of this study is to assess the effect of long-term uptake of cadmium chloride on selected biochemical parameters and oxidative stress biomarkers in animal models. Long-term intoxication with cadmium chloride elevated blood serum concentration of urea, creatinine, glucose, AspAT and AlAT activity as well as TBARS and protein carbonyl group concentrations; TBARS concentration in erythrocytes was also elevated as well as 8-hydroxy-2’-deoxyguanosine excretion with urine.

Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium

88%

Kowalczyk E., Kopff A., Fijalkowski P., Kopff M., Niedworok J., Blaszczyk J., Kedziora J., Tyslerowicz P.

Acta Biochimica Polonica

2003

tom 50

nr 2

Cadmium is a dangerous occupational and environmental toxin. It accumulates in the human organism mainly in liver and kidneys. Cadmium half-life is about 10 years, so the symptoms of cadmium intoxication may occur several years after the exposure. Until now in treating intoxication with this metal chelating compounds have been used, burdened with numerous undesirable symptoms. In our investigations antho- cyanins from Aronia melanocarpa were used to reduce the harmful results caused by cadmium. Administering anthocyanins with cadmium chloride resulted in a statistically significant decrease of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, concentration of bilirubin and urea in blood serum and decreased cadmium cumulation in liver and kidneys in relation to animals receiving cadmium chloride only.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Polish Journal of Environmental Studies

2 Kowalczyk E.

2 Niedworok J.

2 Tyslerowicz P.

1 Blaszczyk J.

1 Fijalkowski P.

1 Jankowski A.

1 Kedziora J.

1 Kopff A.

1 Kopff M.

1 Smigielski J.

1 2003

1 2002

Wyniki wyszukiwania

Effect of long-term cadmium intoxication on selected biochemical parameters in experimental animals

Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium