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On the metabolism of prostaglandin E1 administered intravenously to human volunteers

100%

Peskar B. A., Cawello W., Rogatti W., Rudofsky G.

Journal of Physiology and Pharmacology

1991

tom 42

nr 3

We have demonstrated recently the formation of a biologically active metabolite of prostaglandin (PG) E₁, 13,14-dihydro-PGE₁, during intravenous infusions of PGE₁ in patients with peripheral arterial occlusive disease. We have now investigated the levels of the immediate precursor of 13,14-dihydro-PGE₁ , the biologically inactive 15-keto-13,14-dihydro-PGE₁, during intravenous administration of 20 pig, 40pig or 80 pig PGE₁ over a period of 60 min to human volunteers. It was found that levels of 15-keto-13,14- -dihydro-PGE₁, but not those of PGEx itself, increased in a dose-dependent manner. Thus, increased formation of 13,14-dihydro-PGE₁ from 15-keto- 13,14-dihydro-PGE₁ with increasing doses of PGE₁ can be expected to occur. It remains to be investigated, to which extent formation of small amounts of 13,14-dihydro-PGE₁ during intravenous infusion of PGE₁ could contribute to the therapeutic effects of PGE₁ in patients with peripheral arterial occlusive disease.

Compensating crural anastomoses in chronic critical limb ischaemia

100%

Szpinda M.

Folia Morphologica

2005

tom 64

nr 1

17-21

Compensating crural anastomoses develop in patients with multi-level occlusion of the calf arteries in the course of atherosclerosis, arteriitis, diabetes, and in vascular malformations of the limbs. The peroneal artery is frequently the only patent calf vessel, especially in diabetic patients who have advanced tibial occlusive disease. The purpose of this study was to identify different types of compensating crural anastomoses in chronic critical limb ischaemia. Using combined anatomical-radiographic and statistical methods, 86 compensating crural anastomoses were studied in 59 specimens of lower limbs (amputated at the thigh) in the course of chronic critical ischaemia. Three types of compensating crural anastomosis and their components were identified. The most common type (55.8%) was the posterior tibioperoneal anastomosis. Less common (23.3%) was the intertibial anastomosis and least common (20.9%) the anterior tibioperoneal anastomosis. The posterior tibioperoneal anastomosis was concurrent with anterior tibioperoneal anastomosis in 26.3% of cases and with the intertibial anastomosis in 15.3% of cases. The great importance of the peroneal artery in the formation of natural crural collateral circulation should encourage vascular surgeons to consider peroneal bypasses.

Ograniczanie wyników

1 Folia Morphologica

1 Journal of Physiology and Pharmacology

1 Cawello W.

1 Peskar B. A.

1 Rogatti W.

1 Rudofsky G.

1 Szpinda M.

1 2005

1 1991

Wyniki wyszukiwania

On the metabolism of prostaglandin E1 administered intravenously to human volunteers

Compensating crural anastomoses in chronic critical limb ischaemia