Wyniki wyszukiwania

1

Influence of preterm delivery on ghrelin and obestatin concentrations in maternal plasma, milk and their expression in mammary epithelial cells

100%

Slupecka-Ziemilska M., Wolinski J., Herman A. P., Romanowicz K., Dziegelewska Z., Borszewska-Kornacka M. K.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 5

2

Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer

100%

Gurgul E., Kasprzak A., Blaszczyk A., Biczysko M., Surdyk-Zasada J., Seraszek-Jaros A., Ruchala M.

Folia Histochemica et Cytobiologica

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2015

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tom 53

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nr 1

3

Ghrelin gene products in acute and chronic inflammation

80%

Prodam F., Filigheddu N.

Archivum Immunologiae et Therapiae Experimentalis

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2014

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tom 62

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nr 5

4

Obestatin stimulates the secretion of pancreatic juice enzymes through a vagal pathway in anaesthetized rats - preliminary results

80%

Kapica M., Zabielska M., Puzio I., Jankowska A., Kato I., Kuwahara A., Zabielski R.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 3

123-130

5

Pretreatment with obestatin inhibits the development of cerulein-induced pancreatitis

80%

Ceranowicz P., Warzecha Z., Dembinski A., Cieszkowski J., Dembinski M., Sendur R., Kusnierz-Cabala B., Tomaszewska R., Kuwahara A., Kato I.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 3

95-101

Obestatin is a peptide derived from the proghrelin, a common prohormone for ghrelin and obestatin. Obestatin, like the ghrelin has been originally extracted from rat stomach, and the stomach seems to be a major source of circulating obestatin. Previous studies have shown that administration of ghrelin exhibits protective effect in the pancreas, inhibiting the development of acute pancreatitis. Recent study has shown that obestatin promotes survival of ß-cells and pancreatic islets. Aim of the present study was to investigate the influence of obestatin administration on the development of cerulein-induced pancreatitis. Studies were performed on male Wistar rats. Acute pancreatitis was induced by cerulein given intraperitoneally 5 times at a dose of 50 µg/kg/dose with 1-h intervals. Obestatin was injected twice intraperitoneally at the dose of 4, 8 or 16 nmol/kg/dose. In control saline-treated rats, obestatin was without effect on pancreatic morphology, serum activity of pancreatic enzymes, serum level of pro-inflammatory interleukin-1b or pancreatic cells proliferation. In animals with induction of acute pancreatitis, morphological examination showed that administration of obestatin decreased pancreatic leukocyte infiltration and vacuolization of acinar cells. These effects were accompanied by reduction in the pancreatitis-evoked increase in serum level of pancreatic digestive enzymes, lipase amylase and poly-C ribonuclease. Obestatin administered at the highest dose of 16 nmo/kg/dose reduced serum activity of these enzymes by 33, 42 and 44%, respectively. Also serum concentration of pro-inflammatory interleukin-1ß was decreased by obestatin in rats with acute pancreatitis; whereas the pancreatitis-evoked decrease in pancreatic blood flow and pancreatic DNA synthesis was partially reversed. Administration of obestatin reduces the severity of cerulein-induced acute pancreatitis. This effect is related, at least in part, to the improvement of pancreatic blood flow and reduction in pro-inflammatory interleukin-1ß release.

6

Feeding behavior and body weight development: lessons from rats subjected to gastric bypass surgery or high-fat diet

80%

Furnes M. W., Zhao C.-M., Stenstrom B., Arum C.-J., Tommeras K., Kulseng B., Chen D.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 7

7

Role of feed-regulating peptides on pancreatic exocrine secretion

80%

Kapica M., Puzio I., Kato I., Kuwahara A., Zabielski R.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 2

In recent two decades a group of feed intake-regulating peptides (i.e., leptin, apelin, ghrelin, obestatin and orexins) have been discovered. Besides the central nervous system these regulatory peptides are produced and released by the gastrointestinal (GI) endocrine cells and neurons, and functional receptors were found in the GI tract and the pancreas. High expression of feed intake-regulating peptides was found in the stomach; however, they may be expressed in other GI tissues too. The peptides control gastrointestinal functions, modulate orexigenic drive and energy metabolism via different mechanisms. Basal leptin, apelin, ghrelin and obestatin plasma concentrations correlated with BMI, and we observed significant reduction of ghrelin and leptin concentrations following fundectomy in rats. We have shown previously that exogenous leptin and ghrelin (a peptide derived from the same preprohormone as obestatin) inhibit the secretion of rat pancreatic juice through a neurohormonal mechanism. Intravenous obestatin was found to stimulate pancreatic protein output in anaesthetized rat via a CCK-vagal-dependent mechanism, whilst a direct action of obestatin on rat pancreatic acini in vitro resulted in opposite effect. Intravenous boluses of apelin reduced the juice volume, protein and trypsin outputs in a dose-dependent manner. However, apelin administered into the duodenal lumen significantly increased pancreatic protein and trypsin outputs through a vagal mechanism. Orexin A and B were found to stimulate insulin release, though on the rat exocrine pancreas orexin A had no effect, and the effect of orexin B was weak. Concluding, feed intake-regulating peptides participate in controlling the exocrine pancreas.

Ograniczanie wyników

Influence of preterm delivery on ghrelin and obestatin concentrations in maternal plasma, milk and their expression in mammary epithelial cells

Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer

Ghrelin gene products in acute and chronic inflammation

Obestatin stimulates the secretion of pancreatic juice enzymes through a vagal pathway in anaesthetized rats - preliminary results

Pretreatment with obestatin inhibits the development of cerulein-induced pancreatitis

Feeding behavior and body weight development: lessons from rats subjected to gastric bypass surgery or high-fat diet

Role of feed-regulating peptides on pancreatic exocrine secretion