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Dopamine D2 receptor gene polymorphism and body mass

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Wlodarczyk M., Jarosz A., Nowicka G.

Żywienie Człowieka i Metabolizm

2009

tom 36

nr 4

Dopamine plays a role in the regulation of appetite. Polymorphism in dopamine receptor gene may influence obesity development by their potential impact on dopamine reward function. The aim of the study was to investigate prevalence of TaqI A D2 dopamine receptor genotypes in relation to degree of obesity. Polymorphic variants of DRD2 gene was determined by PCR-RFLP method in 266 subjects. The A1 allele and the A1 allele containing genotypes were more frequent in the obese subjects than in non-obese subjects (43% vs. 14% for A1A1; 40% vs. 35% for A1A2; 32% vs 22% for A1 allele, respectively). Our findings are in line with the hypothesis of the involvement of gene implicated in dopamine regulation in development of obesity.

Ograniczanie wyników

1 Żywienie Człowieka i Metabolizm

1 Jarosz A.

1 Nowicka G.

1 Wlodarczyk M.

1 2009

Wyniki wyszukiwania

Dopamine D2 receptor gene polymorphism and body mass