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New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy

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Gosselin G., Girardet J. L., Perigaud C., Benzaria S., Lefebvre I., Schlienger N., Pompon A., Imbach J. L.

Acta Biochimica Polonica

1996

tom 43

nr 1

The rationale for a pronucleotide approach based on the use of phosphotriesters which incorporate enzyme-mediated bio-labile protection is discussed in detail. Among the studied bio-labile phosphate protecting groups, the S-acyl-2-thioethyl (SATF.) groups appeared the most promising as exemplified in cell culture systems in the case of the pronucleotides of 3'-a7.ido-3'-deoxythymidine, 2',3'-didehydro- -3-deoxythymidine, 2'„3-dideoxyadenosine and acyclovir. 7m vivo implementations of such bis(SATE) pronucleotides have been planned for future animal studies.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Benzaria S.

1 Girardet J. L.

1 Gosselin G.

1 Imbach J. L.

1 Lefebvre I.

1 Perigaud C.

1 Pompon A.

1 Schlienger N.

1 1996

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New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy