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1

Inhibition of EGFR nuclear shuttling decreases irradiation resistance in HeLa cells

100%
Wei H., Zhu Z., Lu L.
Folia Histochemica et Cytobiologica
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2017
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tom 55
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nr 2
2

Ribosome biogenesis and nucleolar function in yeast Saccharomyces cerevisiae

100%
Gromadka R., Rytka J.
Cellular and Molecular Biology Letters
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2000
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tom 05
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nr 2
This review provides an overview of the current knowledge of ribosome biogenesis, nucleolus structure and function and protein traffic into and out of the nucleus, with emphasis on the potential of yeast Saccharomyces cerevisiae as a model organism.
3
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Impaired angiogenesis in aging myocardial microvascular endothelial cells is associated with reduced importin alpha and decreased nuclear transport of HIF1alpha: mechanistic implications

80%
Ahluwalia A., Narula J., Jones M. K., Deng X., Tarnawski A. S.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 2
Aging is associated with increased incidence of myocardial infarctions and impaired angiogenesis - new capillary blood vessel formation from preexisting vessels. The molecular mechanism(s) of aging-related impairment of angiogenesis are unknown. In the present study we focused on the mechanism of activation of the gene for vascular endothelial growth factor (VEGF - the most potent stimulator of angiogenesis) in young and aging myocardial microvascular endothelial cells (MMEC). Activation of VEGF gene in the cell nucleus is mediated in part by the transcription factor hypoxia-inducible factor 1 (HIF1). In order to activate VEGF gene, HIF1 must first be transported to the nucleus, but the mechanisms of this transport are unknown. We hypothesized that reduced VEGF gene activation and impaired angiogenesis in myocardium during aging can result from downregulation of the nuclear transport receptor - importin that leads to decreased transport of HIF1 to the nucleus. We examined in MMEC isolated from young (3 months of age) and aging (24 months old) Fisher F-344 rats: 1) in vitro angiogenesis; and 2) the expression of VEGF, importin and HIF1. Aging MMEC exhibited a 3.7-fold reduction in angiogenesis and a corresponding reduction in VEGF (by 3-fold) and importin (by 1.9-fold) levels compared to young MMEC. Aging MMEC also exhibited cytoplasmic accumulation (by 1.8-fold) of HIF1 protein, reduced HIF1 transport to the nucleus and decreased binding of HIF1 protein to the VEGF gene promoter. This study is the first demonstration of the downregulation of importin in aging MMEC and reduced nuclear transport of HIF1, which likely lead to decreased VEGF gene activation and impaired angiogenesis.
4

Structure of small G proteins and their regulators

80%
Paduch M., Jelen F., Otlewski J.
Acta Biochimica Polonica
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2001
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tom 48
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nr 4
In recent years small G proteins have become an intensively studied group of regula­tory GTP hydrolases involved in cell signaling. More than 100 small G proteins have been identified in eucaryotes from protozoan to human. The small G protein superfamily includes Ras, Rho Rab, Rac, Sar1/Arf and Ran homologs, which take part in numerous and diverse cellular processes, such as gene expression, cytoskeleton re­organization, microtubule organization, and vesicular and nuclear transport. These proteins share a common structural core, described as the G domain, and significant sequence similarity. In this paper we review the available data on G domain structure, together with a detailed analysis of the mechanism of action. We also present small G protein regulators: GTPase activating proteins that bind to a catalytic G domain and increase its low intrinsic hydrolase activity, GTPase dissociation inhibitors that stabi­lize the GDP-bound, inactive state of G proteins, and guanine nucleotide exchange fac­tors that accelerate nucleotide exchange in response to cellular signals. Additionally, in this paper we describe some aspects of small G protein interactions with down­stream effectors.
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